Using novel computational and biochemical approaches, HHMI scientists have designed and built from scratch 10 large protein icosahedra that are similar to viral capsids that carry viral DNA.
International research team unveils new data describing the interaction between genetic and epigenetic variation in Arabidopsis thaliana.
Janelia scientists find that a molecule best known for its role in pain perception also plays an important role in regulating body weight.
HHMI scientists have pioneered the use of genome editing to trace lineage in living systems.
Researchers have discovered that fat tissue is a previously unrecognized reservoir of trypanosomes, the parasites that cause sleeping sickness.
HHMI scientists have designed a potential cancer therapy that uses a unique strategy to block a molecule that drives the growth of cancer.
New experiments help explain how the brain speeds up or slows down movement.
Analyses of ancient DNA from prehistoric humans paint a picture of dramatic population change in Europe from 45,000 to 7,000 years ago.
On May 18, Michael Kennedy will deliver a talk, “The Power of Community: Improving STEM Futures for Urban Youth” at 7:00 p.m. at Janelia Research Campus
New research from Janelia scientists suggests the brain is organized into modules that work together to maintain critical functions, even in the face of disturbances.
HHMI scientists have discovered a command center in the brain that controls how much insects eat and how quickly they consume their food.
HHMI, the Bill & Melinda Gates Foundation, the Wellcome Trust, and the Calouste Gulbenkian Foundation announce the International Research Scholars Program which aims to support up to 50 outstanding early career scientists worldwide.
In only the second time in history, all five Canada Gairdner International Awards are being given to one topic -- CRISPR-Cas technology.
HHMI scientists identify a region of the brain that is critical in translating danger signals detected by the nose into physiological responses.
Janelia announces the establishment of the neuronal cell biology program and recruitment of the first group leaders.
HHMI scientists identify a gene that might serve as a molecular link between mood and the circadian clock.
HHMI researchers have identified 27 genes in brain stem cells that are prone to a type of DNA damage called double-strand breaks.
New study suggests why mice with cystic fibrosis mutations can stave off bacterial infections in their lungs.
New experiments at HHMI's Janelia Research Campus show that activity in the cortex is critical for enacting a learned skill.
The MouseLight Project team at Janelia unveils a microscope and method for long-range tracing of neurons in the mouse brain.
New study suggests that graded changes in gene expression are an organizing principle for CA1 pyramidal cells in the hippocampus.
On February 24, HHMI investigator Bonnie Bassler will deliver a talk, “Tiny Conspiracies: Cell-to-Cell Communication in Bacteria,” at 7:00 p.m. at Janelia Research Campus.
Research uncovers new information about the biological processes that help ensure that two fly species don't interbreed.
HHMI researchers have discovered a molecular mechanism that enables plants to detect when they are in the shade of other plants and adapt by speeding up their growth.
Using an advanced imaging system with adaptive optics, Janelia scientists have uncovered new details about how the brain processes visual information.
New research examines why some children born with heart defects also have developmental disabilities.
Researchers learn more details about how CRISPR works in cells.
Scientists show they can control whether mice perceive a taste as bitter or sweet by activating two small areas of the brain.
HHMI investigators Karl Deisseroth and Helen Hobbs are among five scientists honored for transformative advances toward understanding living systems and extending human life.
HHMI scientists have identified a set of proteins that plays a surprisingly broad role in guiding tissue formation in plant roots.
Within less than a second, the new IsoView microscope produces images of entire organisms, such as a zebrafish or fruit fly embryo, with enough resolution in all three dimensions that each cell appears as a distinct structure.
HHMI's Paul Modrich shares 2015 Nobel Prize in Chemistry with Tomas Lindahl and Aziz Sancar for studies of DNA repair.
New research indicates individual human neurons may harbor up to 1,000 genetic mutations.
HHMI Investigator Stephen Elledge of Brigham and Women's Hospital shares the 2015 Albert Lasker Basic Medical Research Award with Evelyn Witkin of Rutgers University.
New imaging methods dramatically improve the spatial resolution provided by structured illumination microscopy, one of the best imaging techniques for seeing inside living cells.
HHMI scientists have discovered how the most common genetic defect in amyotrophic lateral sclerosis kills nerve cells.
HHMI researchers solve a longstanding mystery about the origin of new cells in the liver.
A lipid molecule called EET helps blood-forming stem cells replenish the immune system.
New research begins to explain how plants separate microbes they like from those they don't like.
HHMI scientists have profiled key features of the genetic material inside three types of brain cells and found vast differences in the patterns of chemical modifications that affect how the genes in each type of neuron are regulated.
New studies provide the first genetic evidence that humans interbred with Neanderthals in Europe.
New technology developed by HHMI researchers makes it possible to test for current and past infections with any known human virus by analyzing a single drop of blood.
New research hints at strategies fruit flies use to keep track of where they are going, even when it's dark.
Studying fruit fly larvae, Janelia scientists have mapped the entire neural circuit involved in combining vibration and pain sensations used in triggering an escape behavior.
Negative emotions associated with hunger can make it hard to maintain a diet and lose weight. Hunger-sensitive cells in the brain may help explain that struggle.
HHMI researchers develop a new single-cell imaging technique that reveals the copy numbers and locations of thousands of RNA molecules inside a cell.
HHMI researchers identify a rare genetic mutation that tamps down immune response to influenza.
HHMI scientists have designed a revolutionary "3D printer" for small molecules that could open the power of customized chemistry to many.
Scientist at Janelia Research Campus wins The Brain Prize for helping to develop a tool that advances our understanding of how the brain's networks process information.
A new way of thinking challenges standard notions about what a herpes vaccine should look like.
Scientists at Janelia Research Campus have identified a neural circuit that connects motor planning to movement.
A new tool developed at HHMI's Janelia Research Campus lets scientists permanently mark neurons that are active at a particular time.
New studies by HHMI scientists show how cells use sophisticated signaling mechanisms to control production of interferon.
HHMI researchers have identified a neural circuit in the subfornical organ that regulates thirst in mice.
When battling a chronic infection, killer T cells must take a break so they can continue to fight off infection.
Janelia researchers show that Hox proteins trigger gene activity through weak interactions at previously unrecognized DNA binding sites in the genome.
Scientists have determined new structures of an essential cellular recycling machine with near atomic-level detail. The structures, which show a protein called NSF alone and interacting with its target, a protein complex called SNARE that is formed when membranes fuse together.
HHMI scientists and their colleagues discover a new mechanism of protein synthesis.
Researchers at HHMI's Janelia Research Campus have used motion-capture technology to reveal new insight into the sophisticated information processing and acrobatic skills of dragonflies on the hunt.
HHMI investigator Jennifer Doudna is among six scientists honored for transformative advances toward understanding living systems and extending human life.
Lattice light sheet microscopy, a new imaging platform developed at Janelia, lets biologists see 3-D images of subcellular activity in real time.
Janelia group leader Eric Betzig wins Nobel Prize for the development of super-resolved fluorescence microscopy.
Retracing the ancient battles between jumping genes and the defenses human cells deploy to keep them in check.
Janelia scientists are learning how the brain switches between random and strategic modes.
HHMI scientists have shown that previously unrecognized groups contributed to the genetic mix now present in most modern-day Europeans.
HHMI Investigator Sangeeta Bhatia is recognized for designing and commercializing miniaturized technologies with applications to improve human health.
HHMI Investigator Peter Walter of UCSF shares the 2014 Albert Lasker Basic Medical Research Award with Kazutoshi Mori of Kyoto University.
New research by HHMI scientists shows that the emotional memory of an experience is malleable.
Janelia scientists are learning how the brain makes sense of new places.
HHMI scientists have devised a technique to identify hard-to-find gene mutations that crop up in a fraction of the body's cells.
By studying dirty flies, Janelia scientists hope to learn how animals carry out sequences of movements that make up more complex behaviors.
Big data can mean big headaches for scientists. A new library of software tools from Janelia speeds analysis of data sets so large and complex they would take days or weeks to analyze on a single workstation—if a single workstation could do it at all.
Janelia researchers develop a new computational method that can essentially automate much of the time-consuming process of reconstructing an animal's developmental building plan cell by cell.
HHMI and GBMF announce the establishment of an Advanced Imaging Center at Janelia that will make leading-edge imaging technologies more widely available to the scientific community before the instruments are available commercially.
Every millisecond counts when a fruit fly is being hunted by a damselfly. Janelia scientists find that fruit flies can deploy two escape behaviors, depending on circumstances.
HHMI researchers find that a single-letter change in the genetic code is enough to generate blond hair in humans.
HHMI scientists develop new tool to silence neurons with an unprecedented level of control.
Janelia researchers speed up image-processing time and get sharper microscopy images by employing techniques used by astonomers and ophthalmologists.
John P. Donoghue, Director of the Institute for Brain Science at Brown University, will speak on April 30 at 7PM at Janelia.
HHMI researchers have tested the olfactory capacity of human volunteers and found that humans are capable of discriminating at least one trillion different odors.
HHMI researchers show that rising temperatures can cause spread of malaria to areas where the disease had not been endemic historically.
Howard Hughes Medical Institute (HHMI) scientists have created a portrait of a DNA-snipping protein called Cas9, a powerful research tool used in many labs for genome editing.
New research from HHMI scientists reveals how a foreign-DNA-destroying system, known as CRISPR, efficiently locates its DNA targets within a bacterial genome.
By studying which genes modern humans still retain from our Neanderthal ancestors, researchers are able to tell a clearer story about the biological impact of human-Neanderthal interbreeding.
HHMI seeks to appoint up to 25 new biomedical researchers through a national open competition.
HHMI researchers identify a potential Achilles heel in the oncogene K-Ras.
A new technique developed by Janelia researchers allows scientists to use electron beams to determine protein structure from tiny crystals.
New evidence suggests that aneuploidy patterns of chromosome deletion or amplification that are recurrent among tumors actually represent a driving force during tumor evolution and are very frequent in cancer.
HHMI researchers have discovered that the pool of inactive HIV viruses that lingers silently in a patient’s body is larger than expected. The viruses continue to be a threat because they retain the ability to become active even after treatment with the best HIV drugs.
HHMI researchers have developed a mouse model of scleroderma. Their studies have uncovered some of the molecular pathways that go awry to cause the disease.
Neurons deep in the fly’s brain tune in to some of the same basic visual features that neurons in bigger animals such as humans pick out in their surroundings. The new research is an important milestone toward understanding how the fly brain extracts relevant information about a visual scene to guide behavior.
HHMI researchers have designed an inhibitor that can reduce the expression of the mutated gene that causes hypertrophic cardiomyopathy, a potentially fatal heart condition.
The Nobel Assembly at the Karolinska Institute announced that HHMI investigators Randy W. Schekman and Thomas C. Südhof, and Yale's James E. Rothman are the recipients of the 2013 Nobel Prize in Physiology or Medicine for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells.
Janelia scientists launch collaboration to develop a new generation of devices to detect neural activity.
Some breast cancer cells have a leg up on survival—the genes they express make them more likely to spread and prosper in bone tissue.
Scientists have discovered that an active ingredient in an over-the-counter skin cream slows or stops the effects of Parkinson’s disease on brain cells.
New thinking and technological innovation help Janelia researchers piece together a complex map of the neuronal connections that flies use to detect motion.
By activating a subset of brain cells in mice, researchers changed the way the animals remembered a particular setting.
New research reveals the cellular network that activates temperature-sensitive changes in an infectious fungus.