For some developmental genes, one allele must stay silent, otherwise debilitating syndromes and cancers can arise. HHMI Investigator Yi Zhang and his colleagues have uncovered a new imprinting mechanism cells use to keep these genes quiet in mice.
Scientists at HHMI’s Janelia Research Campus created comprehensive brain maps linking different groups of neurons to specific behaviors, using a machine-learning program that annotated more than 225 days of videos of flies – a feat that would have taken humans some 3,800 years.
HHMI has selected 24 schools in the first round of the Inclusive Excellence initiative, a program that aims to help increase the capacity of colleges and universities to effectively engage all students so that they can be successful in science, especially undergraduates who enter four-year institutions via nontraditional pathways.
Karl Deisseroth honored with research award for work on the biological basis of psychiatric disorders.
Vale shares $1.2 million award for discovery of molecular motor proteins.
Janelia Research Campus scientists have uncovered new clues about how fruit flies keep track of where they are in the world. Understanding the neural basis of navigation in flies may reveal how humans accomplish similar feats.
In studies with mice, Janelia researchers discovered that to maintain certain short-term memories, the brain’s cortex relies on connections with the thalamus.
HHMI, the Bill & Melinda Gates Foundation, the Wellcome Trust, and the Calouste Gulbenkian Foundation announce the selection of 41 International Research Scholars, early-career scientists poised to advance biomedical research across the globe.
Hypoxia reverses brain damage caused by mitochondrial dysfunction, HHMI team finds. The approach might one day point to new therapies for people with Leigh syndrome and other mitochondrial disorders.
Thirteen HHMI scientists have been elected to the National Academy of Sciences.
The Science Education Alliance is announcing the inclusion of its tenth cohort of 15 institutions in the US, as well as the University of Lagos, Nigeria, and Universidad Autónoma de Nuevo León, Mexico.
The HHMI Medical Research Fellows Program allows exceptional MD, DVM, and DDS students to shift course and conduct rigorous research at top institutions throughout the US.
New HHMI research reveals that adding or deleting chromosomes in cells and animals prompts a wide variety of outcomes. The work could help scientists better understand chromosomal abnormalities in humans.
HHMI Investigator Huda Zoghbi is one of seven scientists honored with prestigious awards from Canada's Gairdner Foundation.
HHMI will appoint up to 20 new biomedical researchers through a national open competition.
New research adds to growing evidence that Parkinson's disease may arise in part from neurons’ failure to recycle the materials used to package and transport neurotransmitters.
The Associated Press and HHMI’s Department of Science Education announce a yearlong collaboration on two pilot projects designed to expand AP’s science journalism.
HHMI scientists develop a much-needed genetic resource that is aiding development of wheat plants with improved traits.
HHMI investigators Stephen Elledge, Roel Nusse and Huda Zoghbi are among the scientists honored for transformative advances toward understanding living systems and extending human life.
HHMI researchers identify the mechanisms that pathogenic bacteria use to waterlog the space between plant cells in the leaves, allowing the bacteria to reproduce and spread infection.
Eight HHMI scientists are among 391 new Fellows of the American Association for the Advancement of Science.
Janelia scientists have developed the first adaptive light-sheet microscope — an instrument that continuously analyzes and adapts to dynamic changes in a specimen and thereby improves spatial resolution.
HHMI researchers find that a gene that blocks the differentiation of pigment-producing cells in the skin of the African striped mouse helps in generating the mouse’s characteristic light-colored stripes.
The first unbiased genetic screen for sleep defects in mice yields two interesting mutants, Sleepy, which sleeps excessively, and Dreamless, which lacks rapid eye movement sleep.
Janelia scientists are learning how animals adjust their physical exertion as changes in the environment or their own bodies alter how efficiently they move.
Three HHMI investigators and two HHMI professors have been elected to membership in the National Academy of Medicine.
A new viral vector will help scientists understand large-scale neural networks.
HHMI researchers have learned to program T cells as if they were "microscopic robots" -- to sense inputs and to respond.
HHMI, the Simons Foundation, and the Bill & Melinda Gates Foundation announce the selection of 84 Faculty Scholars, early-career scientists who have great potential to make unique contributions to their field.
Two films and one short film series produced by HHMI’s Tangled Bank Studios and BioInteractive won awards at the Jackson Hole Science Media Awards.
New program aims to recruit and retain early-career scientists who are from gender, racial, ethnic, and other groups underrepresented in the life sciences, including those from disadvantaged backgrounds.
Lasker Award honors research showing how cells from humans and most animals sense and adapt to changes in oxygen availability.
HHMI awards research fellowships to 20 predoctoral students from 14 countries to help them complete their graduate studies in the U.S.
Janelia scientists have identified a gene that causes male Drosophila to produce different courtship songs.
Using novel computational and biochemical approaches, HHMI scientists have designed and built from scratch 10 large protein icosahedra that are similar to viral capsids that carry viral DNA.
HHMI selects 34 new Gilliam Fellows -- outstanding young scientists who have expressed a clear commitment to advancing diversity among scientists.
The KwaZulu-Natal Research Institute for TB-HIV and the Africa Centre for Population Health join forces to form a new interdisciplinary institute to fight tuberculosis, HIV and related diseases.
International research team unveils new data describing the interaction between genetic and epigenetic variation in Arabidopsis thaliana.
Janelia scientists find that a molecule best known for its role in pain perception also plays an important role in regulating body weight.
HHMI scientists have pioneered the use of genome editing to trace lineage in living systems.
HHMI Investigator David E. Clapham, MD, PhD, will become Vice President and Chief Scientific Officer, effective September 1, 2016.
Zoghbi shares Shaw Prize for research leading to discovery of genes and proteins involved in Rett syndrome.
Researchers have discovered that fat tissue is a previously unrecognized reservoir of trypanosomes, the parasites that cause sleeping sickness.
Ninety-one schools have been invited to submit full proposals to apply for grants through HHMI’s $60 million Inclusive Excellence initiative that is encouraging colleges and universities to broaden access to science excellence for all students.
HHMI scientists have designed a potential cancer therapy that uses a unique strategy to block a molecule that drives the growth of cancer.
A new partnership between HHMI’s Educational Media Group and the Biomedical Neuroscience Institute (BNI) at Universidad de Chile will provide teachers and students in Latin America with free access to science education materials produced by HHMI BioInteractive.
Profesores y estudiantes de América Latina tendrán libre acceso a los materiales de multimedia de educación científica producidos por HHMI BioInteractive que han sido premiados, gracias a una nueva colaboración entre el Grupo de Medios Educativos del HHMI y el Instituto de Neurociencia Biomédica (BNI) de la Universidad de Chile.
HHMI launches new program to provide advanced technology for use in core facilities that are intended to serve a cohort of users – including researchers from outside the HHMI community.
New experiments help explain how the brain speeds up or slows down movement.
HHMI scientists are among 84 newly elected members and 21 foreign associates.
Analyses of ancient DNA from prehistoric humans paint a picture of dramatic population change in Europe from 45,000 to 7,000 years ago.
Sixty-six medical and veterinary students from 34 schools across the nation will spend a full year of mentored biomedical research training as fellows in HHMI's Medical Research Fellows Program.
On May 18, Michael Kennedy will deliver a talk, “The Power of Community: Improving STEM Futures for Urban Youth” at 7:00 p.m. at Janelia Research Campus
New research from Janelia scientists suggests the brain is organized into modules that work together to maintain critical functions, even in the face of disturbances.
Up to 15 new HHMI professors will receive $1 million over five years to develop innovative approaches to teaching undergraduate science.
HHMI scientists have discovered a command center in the brain that controls how much insects eat and how quickly they consume their food.
HHMI, the Bill & Melinda Gates Foundation, the Wellcome Trust, and the Calouste Gulbenkian Foundation announce the International Research Scholars Program which aims to support up to 50 outstanding early career scientists worldwide.
In only the second time in history, all five Canada Gairdner International Awards are being given to one topic -- CRISPR-Cas technology.
HHMI scientists identify a region of the brain that is critical in translating danger signals detected by the nose into physiological responses.
Janelia announces the establishment of the neuronal cell biology program and recruitment of the first group leaders.
HHMI scientists identify a gene that might serve as a molecular link between mood and the circadian clock.
Debora Spar, PhD, president of Barnard College, is HHMI's newest Trustee.
HHMI researchers have identified 27 genes in brain stem cells that are prone to a type of DNA damage called double-strand breaks.
New study suggests why mice with cystic fibrosis mutations can stave off bacterial infections in their lungs.
The HHMI Trustees have named Erin O'Shea the Institute's sixth president, succeeding Robert Tjian.
New experiments at HHMI's Janelia Research Campus show that activity in the cortex is critical for enacting a learned skill.
Biologist, educator, and author Sean B. Carroll honored with prestigious literary prize.
The MouseLight Project team at Janelia unveils a microscope and method for long-range tracing of neurons in the mouse brain.
New study suggests that graded changes in gene expression are an organizing principle for CA1 pyramidal cells in the hippocampus.
On February 24, HHMI investigator Bonnie Bassler will deliver a talk, “Tiny Conspiracies: Cell-to-Cell Communication in Bacteria,” at 7:00 p.m. at Janelia Research Campus.
Research uncovers new information about the biological processes that help ensure that two fly species don't interbreed.
HHMI researchers have discovered a molecular mechanism that enables plants to detect when they are in the shade of other plants and adapt by speeding up their growth.
Using an advanced imaging system with adaptive optics, Janelia scientists have uncovered new details about how the brain processes visual information.
New research examines why some children born with heart defects also have developmental disabilities.
Researchers learn more details about how CRISPR works in cells.
Scientists show they can control whether mice perceive a taste as bitter or sweet by activating two small areas of the brain.
HHMI investigators Karl Deisseroth and Helen Hobbs are among five scientists honored for transformative advances toward understanding living systems and extending human life.
HHMI scientists have identified a set of proteins that plays a surprisingly broad role in guiding tissue formation in plant roots.
Within less than a second, the new IsoView microscope produces images of entire organisms, such as a zebrafish or fruit fly embryo, with enough resolution in all three dimensions that each cell appears as a distinct structure.
HHMI's Paul Modrich shares 2015 Nobel Prize in Chemistry with Tomas Lindahl and Aziz Sancar for studies of DNA repair.
New research indicates individual human neurons may harbor up to 1,000 genetic mutations.
HHMI Investigator Stephen Elledge of Brigham and Women's Hospital shares the 2015 Albert Lasker Basic Medical Research Award with Evelyn Witkin of Rutgers University.
HHMI and the Zooniverse launch WildCam Gorongosa, a new citizen science project.
New imaging methods dramatically improve the spatial resolution provided by structured illumination microscopy, one of the best imaging techniques for seeing inside living cells.
HHMI scientists have discovered how the most common genetic defect in amyotrophic lateral sclerosis kills nerve cells.
Four HHMI scientists are among those honored by the prestigious Royal Society.
HHMI researchers solve a longstanding mystery about the origin of new cells in the liver.
HHMI President Robert Tjian will step down in late 2016.
On September 16, Matthew Scott, President of the Carnegie Institution for Science, will deliver a talk, “Exploring the Genes that Built You” at Janelia Research Campus.
HHMI selects 45 predoctoral students from 18 countries to receive fellowships that will help them complete their graduate degrees in the life sciences.
A lipid molecule called EET helps blood-forming stem cells replenish the immune system.
New research begins to explain how plants separate microbes they like from those they don't like.
The Howard Hughes Medical Institute’s newly expanded Gilliam Fellowships for Advanced Study Program has awarded 30 fellowships to outstanding students who are pursuing a PhD in the life sciences and who are committed to increasing diversity among scientists.
HHMI scientists have profiled key features of the genetic material inside three types of brain cells and found vast differences in the patterns of chemical modifications that affect how the genes in each type of neuron are regulated.
New studies provide the first genetic evidence that humans interbred with Neanderthals in Europe.
HHMI announces five-year, $2.3 million grant to support educational activities and infrastructure development at the E.O. Wilson Biodiversity Laboratory in Gorongosa National Park, Mozambique.
New technology developed by HHMI researchers makes it possible to test for current and past infections with any known human virus by analyzing a single drop of blood.
Nueva tecnología desarrollada por investigadores del HHMI hace que se pueda utilizar una gota de sangre de una persona para analizar infecciones presentes y pasadas con cualquier virus humano conocido.
Bassler shares prestigious honor for discovery of quorum sensing, a process that allows bacteria to communicate with each other.
Meet the new 2015 HHMI Investigators.