New study suggests why mice with cystic fibrosis mutations can stave off bacterial infections in their lungs.
The HHMI Trustees have named Erin O'Shea the Institute's sixth president, succeeding Robert Tjian.
New experiments at HHMI's Janelia Research Campus show that activity in the cortex is critical for enacting a learned skill.
Biologist, educator, and author Sean B. Carroll honored with prestigious literary prize.
The MouseLight Project team at Janelia unveils a microscope and method for long-range tracing of neurons in the mouse brain.
New study suggests that graded changes in gene expression are an organizing principle for CA1 pyramidal cells in the hippocampus.
On February 24, HHMI investigator Bonnie Bassler will deliver a talk, “Tiny Conspiracies: Cell-to-Cell Communication in Bacteria,” at 7:00 p.m. at Janelia Research Campus.
Research uncovers new information about the biological processes that help ensure that two fly species don't interbreed.
HHMI researchers have discovered a molecular mechanism that enables plants to detect when they are in the shade of other plants and adapt by speeding up their growth.
Using an advanced imaging system with adaptive optics, Janelia scientists have uncovered new details about how the brain processes visual information.
New research examines why some children born with heart defects also have developmental disabilities.
Researchers learn more details about how CRISPR works in cells.
Scientists show they can control whether mice perceive a taste as bitter or sweet by activating two small areas of the brain.
HHMI investigators Karl Deisseroth and Helen Hobbs are among five scientists honored for transformative advances toward understanding living systems and extending human life.
HHMI scientists have identified a set of proteins that plays a surprisingly broad role in guiding tissue formation in plant roots.
Within less than a second, the new IsoView microscope produces images of entire organisms, such as a zebrafish or fruit fly embryo, with enough resolution in all three dimensions that each cell appears as a distinct structure.
HHMI's Paul Modrich shares 2015 Nobel Prize in Chemistry with Tomas Lindahl and Aziz Sancar for studies of DNA repair.
New research indicates individual human neurons may harbor up to 1,000 genetic mutations.
HHMI Investigator Stephen Elledge of Brigham and Women's Hospital shares the 2015 Albert Lasker Basic Medical Research Award with Evelyn Witkin of Rutgers University.
HHMI and the Zooniverse launch WildCam Gorongosa, a new citizen science project.
New imaging methods dramatically improve the spatial resolution provided by structured illumination microscopy, one of the best imaging techniques for seeing inside living cells.
HHMI scientists have discovered how the most common genetic defect in amyotrophic lateral sclerosis kills nerve cells.
Four HHMI scientists are among those honored by the prestigious Royal Society.
HHMI researchers solve a longstanding mystery about the origin of new cells in the liver.
HHMI President Robert Tjian will step down in late 2016.
On September 16, Matthew Scott, President of the Carnegie Institution for Science, will deliver a talk, “Exploring the Genes that Built You” at Janelia Research Campus.
HHMI selects 45 predoctoral students from 18 countries to receive fellowships that will help them complete their graduate degrees in the life sciences.
A lipid molecule called EET helps blood-forming stem cells replenish the immune system.
New research begins to explain how plants separate microbes they like from those they don't like.
The Howard Hughes Medical Institute’s newly expanded Gilliam Fellowships for Advanced Study Program has awarded 30 fellowships to outstanding students who are pursuing a PhD in the life sciences and who are committed to increasing diversity among scientists.
HHMI scientists have profiled key features of the genetic material inside three types of brain cells and found vast differences in the patterns of chemical modifications that affect how the genes in each type of neuron are regulated.
New studies provide the first genetic evidence that humans interbred with Neanderthals in Europe.
HHMI announces five-year, $2.3 million grant to support educational activities and infrastructure development at the E.O. Wilson Biodiversity Laboratory in Gorongosa National Park, Mozambique.
New technology developed by HHMI researchers makes it possible to test for current and past infections with any known human virus by analyzing a single drop of blood.
Bassler shares prestigious honor for discovery of quorum sensing, a process that allows bacteria to communicate with each other.
Meet the new 2015 HHMI Investigators.
Meet the new 2015 HHMI Investigators.
An accomplished group, the 26 new HHMI investigators are at the forefront of discovery research.
New research hints at strategies fruit flies use to keep track of where they are going, even when it's dark.
HHMI's new science education initiative is challenging colleges and universities to increase their capacity to engage all students in science.
Studying fruit fly larvae, Janelia scientists have mapped the entire neural circuit involved in combining vibration and pain sensations used in triggering an escape behavior.
HHMI scientists are among 84 newly elected members.
Thousands of undergraduate students contribute to new study that broadens understanding of genetic diversity of bacteriophages.
Negative emotions associated with hunger can make it hard to maintain a diet and lose weight. Hunger-sensitive cells in the brain may help explain that struggle.
Eleven HHMI scientists are elected to the American Academy of Arts and Sciences.
Sixty-eight medical and veterinary students from 37 different schools across the country will participate in HHMI's year-long Medical Research Fellows Program.
HHMI researchers develop a new single-cell imaging technique that reveals the copy numbers and locations of thousands of RNA molecules inside a cell.
On May 13, Princeton University President Emerita Shirley Tilghman will deliver a talk, “The Wild and Wacky World of Epigenetics” at 7:00 p.m. at Janelia Research Campus.
HHMI researchers identify a rare genetic mutation that tamps down immune response to influenza.
HHMI, the Bill & Melinda Gates Foundation, and the Simons Foundation launch Faculty Scholars Program to give promising early-career scientists a boost.
HHMI scientists have designed a revolutionary "3D printer" for small molecules that could open the power of customized chemistry to many.
Scientist at Janelia Research Campus wins The Brain Prize for helping to develop a tool that advances our understanding of how the brain's networks process information.
A new way of thinking challenges standard notions about what a herpes vaccine should look like.
Scientists at Janelia Research Campus have identified a neural circuit that connects motor planning to movement.
A new tool developed at HHMI's Janelia Research Campus lets scientists permanently mark neurons that are active at a particular time.
New studies by HHMI scientists show how cells use sophisticated signaling mechanisms to control production of interferon.
HHMI researchers have identified a neural circuit in the subfornical organ that regulates thirst in mice.
When battling a chronic infection, killer T cells must take a break so they can continue to fight off infection.
Janelia researchers show that Hox proteins trigger gene activity through weak interactions at previously unrecognized DNA binding sites in the genome.
On February 18, Janelia group leader Luke Lavis will speak about “The Chemistry of Color” at 7:00 p.m. at Janelia Research Campus.
Scientists have determined new structures of an essential cellular recycling machine with near atomic-level detail. The structures, which show a protein called NSF alone and interacting with its target, a protein complex called SNARE that is formed when membranes fuse together.
HHMI scientists and their colleagues discover a new mechanism of protein synthesis.
Fernando Amat, Philipp Keller, and William Lemon win first prize in the 2014 Olympus BioScapes Digital Imaging Competition for their video that captures the early development of a fruit fly embryo.
Researchers at HHMI's Janelia Research Campus have used motion-capture technology to reveal new insight into the sophisticated information processing and acrobatic skills of dragonflies on the hunt.
HHMI investigator Jennifer Doudna is among six scientists honored for transformative advances toward understanding living systems and extending human life.
Lattice light sheet microscopy, a new imaging platform developed at Janelia, lets biologists see 3-D images of subcellular activity in real time.
Six HHMI scientists have been elected to membership in the Institute of Medicine.
On November 19, Janelia group leader Gwyneth Card will deliver a talk, "Taking Action: How Small Brains Make Big Choices."
Video, images, and related news resources for use by the media in covering the 2014 Nobel Prize in Chemistry.
Janelia group leader Eric Betzig wins Nobel Prize for the development of super-resolved fluorescence microscopy.
Retracing the ancient battles between jumping genes and the defenses human cells deploy to keep them in check.
Janelia scientists are learning how the brain switches between random and strategic modes.
HHMI scientists have shown that previously unrecognized groups contributed to the genetic mix now present in most modern-day Europeans.
HHMI expands the Gilliam Fellowships for Advanced Study, a highly successful program for graduate students who are pursuing a PhD in the life sciences and who are committed to increasing diversity among scientists.
HHMI Investigator Sangeeta Bhatia is recognized for designing and commercializing miniaturized technologies with applications to improve human health.
HHMI Investigator Peter Walter of UCSF shares the 2014 Albert Lasker Basic Medical Research Award with Kazutoshi Mori of Kyoto University.
New research by HHMI scientists shows that the emotional memory of an experience is malleable.
Janelia scientists are learning how the brain makes sense of new places.
HHMI scientists have devised a technique to identify hard-to-find gene mutations that crop up in a fraction of the body's cells.
By studying dirty flies, Janelia scientists hope to learn how animals carry out sequences of movements that make up more complex behaviors.
The September 17 lecture, “Unraveling Infectious Disease Mysteries Through Genomics,” is free, but tickets are required for admission.
The Howard Hughes Medical Institute awards nearly $5 million in research fellowships to 46 predoctoral students from 24 countries.
Big data can mean big headaches for scientists. A new library of software tools from Janelia speeds analysis of data sets so large and complex they would take days or weeks to analyze on a single workstation—if a single workstation could do it at all.
Janelia researchers develop a new computational method that can essentially automate much of the time-consuming process of reconstructing an animal's developmental building plan cell by cell.
Fifteen outstanding researchers from 13 institutions are named HHMI Professors.
HHMI and GBMF announce the establishment of an Advanced Imaging Center at Janelia that will make leading-edge imaging technologies more widely available to the scientific community before the instruments are available commercially.
Every millisecond counts when a fruit fly is being hunted by a damselfly. Janelia scientists find that fruit flies can deploy two escape behaviors, depending on circumstances.
HHMI researchers find that a single-letter change in the genetic code is enough to generate blond hair in humans.
Through its 2014 Sustaining Excellence competition, HHMI is awarding new science education grants that will support activities at 37 research universities.
HHMI selects 37 research universities to receive $60 million in grants to improve how science is taught.
Peter Walter shares prize for discovery of the unfolded protein response of the endoplasmic reticulum.
The University of Maryland, Baltimore County, the Pennsylvania State University, the University of North Carolina at Chapel Hill, and HHMI are working together to learn how to adapt the Meyerhoff Scholars Program at more universities.
HHMI scientists are among ten newly elected foreign members.
HHMI scientists are among 84 newly elected members.
HHMI scientists develop new tool to silence neurons with an unprecedented level of control.
Ten HHMI investigators are elected to the American Academy of Arts and Sciences.
Seventy medical and veterinary students from 37 different schools across the country will be engaging in laboratory research for a full year as participants in the HHMI Medical Research Fellows Program.
Janelia researchers speed up image-processing time and get sharper microscopy images by employing techniques used by astonomers and ophthalmologists.
John P. Donoghue, Director of the Institute for Brain Science at Brown University, will speak on April 30 at 7PM at Janelia.
HHMI researchers have tested the olfactory capacity of human volunteers and found that humans are capable of discriminating at least one trillion different odors.