HHMI researchers identify a potential Achilles heel in the oncogene K-Ras.
A new technique developed by Janelia researchers allows scientists to use electron beams to determine protein structure from tiny crystals.
The Howard Hughes Medical Institute (HHMI) is adding four new films to its award-winning catalog of short science documentaries for the classroom.
Ulrike Heberlein, a scientific program director and laboratory head at the Janelia Farm Research Campus, will deliver a public lecture at Janelia titled, “Alcoholism: 100 Million Years in the Making?”
New evidence suggests that aneuploidy patterns of chromosome deletion or amplification that are recurrent among tumors actually represent a driving force during tumor evolution and are very frequent in cancer.
HHMI researchers have discovered that the pool of inactive HIV viruses that lingers silently in a patient’s body is larger than expected. The viruses continue to be a threat because they retain the ability to become active even after treatment with the best HIV drugs.
Six HHMI scientists have been elected to membership in the Institute of Medicine.
HHMI researchers have developed a mouse model of scleroderma. Their studies have uncovered some of the molecular pathways that go awry to cause the disease.
Neurons deep in the fly’s brain tune in to some of the same basic visual features that neurons in bigger animals such as humans pick out in their surroundings. The new research is an important milestone toward understanding how the fly brain extracts relevant information about a visual scene to guide behavior.
HHMI researchers have designed an inhibitor that can reduce the expression of the mutated gene that causes hypertrophic cardiomyopathy, a potentially fatal heart condition.
La Real Academia de las Ciencias Sueca anunció que los investigadores del HHMI, Randy W. Schekman y Thomas C. Südhof, y James E. Rothman de la Universidad de Yale son los ganadores del Premio Nobel de Fisiología o Medicina 2013 por sus descubrimientos sobre la maquinaria que regula el tráfico de vesículas, un importante sistema de transporte de nuestras células.
The Nobel Assembly at the Karolinska Institute announced that HHMI investigators Randy W. Schekman and Thomas C. Südhof, and Yale's James E. Rothman are the recipients of the 2013 Nobel Prize in Physiology or Medicine for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells.
Janelia scientists launch collaboration to develop a new generation of devices to detect neural activity.
Some breast cancer cells have a leg up on survival—the genes they express make them more likely to spread and prosper in bone tissue.
Scientists have discovered that an active ingredient in an over-the-counter skin cream slows or stops the effects of Parkinson’s disease on brain cells.
Neuroscientist Cori Bargmann will discuss "Ancient Molecules and the Modern Brain: Understanding our Social Nature," at Janelia on September 18.
HHMI awards more than $1.8 million in fellowships to 42 international graduate students studying in the U.S.
Kathryn S. Brown, head of communications, oversees all communications and public relations for the Howard Hughes Medical Institute.
New thinking and technological innovation help Janelia researchers piece together a complex map of the neuronal connections that flies use to detect motion.
HHMI relaunches its primary public website. The new site uses Drupal, an open-source technology.
By activating a subset of brain cells in mice, researchers changed the way the animals remembered a particular setting.
New research reveals the cellular network that activates temperature-sensitive changes in an infectious fungus.
A new protein engineered by scientists at the Janelia Farm Research Campus fluoresces brightly each time it senses calcium, giving the scientists a way to visualize neuronal activity. The new protein is the most sensitive calcium sensor ever developed and the first to allow the detection of every neural impulse.
New research reveals details of changing DNA methylation patterns as the brain matures.
Proteins engineered to bind enhancer regions of the genome offer researchers a window into how genes are activated.
Scientists have identified a gene that enables wheat crops to fight off stem rust, a dreaded fungus that blights wheat fields with rusty brown lesions and reduces yields.
When injected into mice immediately following a traumatic event, a new drug prevents the animals from developing memory problems and increased anxiety that are indicative of post-traumatic stress disorder.
In one of the first successful attempts at genetically engineering mosquitoes, researchers have altered the way the insects respond to odors, including the smell of humans and the insect repellant DEET.
Identification of a cell signaling pathway that affects the levels of the toxic protein responsible for the neurodegenerative disease SCA1 could lead researchers to new drugs.
Sixty-nine medical, dental, and veterinary students from 32 schools across the country will be engaging in laboratory research for a full year as participants in the HHMI Medical Research Fellows Program.
Malaria parasites infecting human red blood cells send packets of information between cells to coordinate group activity. When the parasites are under stress, the communication increases their ability to develop into a new stage of the life cycle.
New research shows that about 10 percent of severe cases of congenital heart disease are caused by genetic mutations that are absent in the parents of affected children.
HHMI announces the selection of 27 HHMI investigators, representing 19 institutions.
Meet the 2013 HHMI Investigators
Meet the 2013 HHMI Investigators
Meet the 2013 HHMI Investigators
Meet the 2013 HHMI Investigators
Two bioengineering professors at Rice University have been named recipients of the 2013 $100,000 Lemelson-MIT Award for Global Innovation.Rebecca Richards-Kortum, an HHMI program director at Rice, and an HHMI Professor, and her colleague, Maria Oden, are being honored for mentoring a new generation of inventors in developing life-saving health technologies for the world¹s poorest communities.
Waging an immunological war against a pathogen is not the body’s only way to survive an infection. Sometimes learning to live with an invader can be just as important.
Scientists have discovered a hormone that causes the body’s insulin-producing factories, beta cells, to churn out more of themselves.
Eddy will speak about "The Language of DNA" on May 22 in an event open to the public.
HHMI has invited 203 research universities to apply for new science education grants aimed at helping improve persistence of students studying STEM disciplines and reinvigorating introductory science courses.
A new technique transforms biological tissue into an optically transparent sample that retains its original structure and molecular information.
Stephen Elledge recognized for research on DNA repair.
New research reveals how a localized source of a signaling molecule directs a dividing stem cell to produce two different cells—one identical to its parent, the other a more specialized cell type—and aligns those cells.
At a briefing at the White House, HHMI announces $22.5 million, five-year grant to help major research universities train a new generation of science and mathematics teachers.
Up to 15 new HHMI professors will receive $1 million over five years to create activities that integrate their research with student learning to enhance undergraduates' understanding of science.
The Howard Hughes Medical Institute selects nine highly talented college students to receive the 2013 Gilliam Fellowships for Advanced Study.
Researchers have found that temperatures on the surface of the tropical South Atlantic Ocean in July can predict the severity of malaria outbreaks in northwestern India that begin to peak four months later.
Scientists have a new view of the cellular machinery that assembles directly on DNA and readies it for transcription into RNA, the first step in protein production.
Misha Ahrens, Shaul Druckmann, Krystyna Keleman, and Minoru Koyama will each lead a small research team working toward learning how the brain’s neural circuits process information and guide behavior.
Células madres en el interior del parásito que causa la esquistosomiasis pueden regenerar los órganos desgastados, lo que podría ayudar a explicar cómo pueden vivir por años o incluso décadas dentro de su huésped.
Stem cells inside the parasite that causes schistosomiasis can regenerate worn-down organs, which may help explain how the parasites can live for years inside their host.
Three HHMI scientists are among 11 honored for excellence in research aimed at curing intractable diseases and extending human life.
Jennifer Tour Chayes, Managing Director of Microsoft Research New England and Microsoft Research New York City, will speak about "Age of Networks" on February 20 at 7 PM.
EarthViewer, a free, interactive app designed for the iPad, lets users explore the Earth's history with the touch of a finger by scrolling through 4.5 billion years of geological evolution.
Científicos han descubierto que arreglos periódicos de actina en forma de anillos rodean las largas fibras axonales de las células nerviosas, en contraste con las redes lineares que comúnmente le dan forma a las células.
Scientists have discovered that periodic ring-shaped actin arrangements encircle the long axonal fibers of nerve cells, in contrast to the linear meshworks that typically give cells their shapes.
HHMI scientists discover how a single molecule in a living cell can respond differently to different strengths of an external signal.
New lab heads Barry Dickson and Nikolaus Grigorieff will move to Janelia in 2013.
A new analysis suggests that the regulatory protein MeCP2 works with the modified nucleotide 5hmC to facilitate gene activation in the brain.
Scientists have discovered the molecular pathway responsible for detecting loose bits of DNA outside a cell’s nucleus and setting off an immune reaction.
Rather than scrutinizing hours of video, scientists can quickly teach the software how to recognize key behaviors.
AAAS recognizes Ulrike Heberlein and Nelson Spruston for meritorious efforts to advance science.
O'Shea, HHMI investigator and professor at Harvard University, will lead HHMI's science programs.
New film and media production company aims to be a significant contributor to the science documentary arena.
Betzig will discuss historical connections between astronomy and microscopy on Dec. 12.
A new DNA sequencing technique has enabled researchers to map for the first time the influential chemical modifications known as methylation marks throughout the genome of a pathogenic bacterium.
Susan Desmond-Hellmann, M.D., M.P.H., chancellor of the University of California, San Francisco, becomes one of 11 Trustees of the Institute.
Hanna H. Gray, Ph.D., former chair of the HHMI Trustees, retires after serving the Institute since 1984.
Sean Carroll introduces "The Day the Mesozoic Died" at national teachers conference.
eLife makes first collection of research articles available online.
Seven HHMI investigators and two members of HHMI’s Scientific Review Board have been elected to the Institute of Medicine of the National Academies.
Robert Lefkowitz de HHMI comparte el premio con Brian Kobilka por estudios sobre los receptores acoplados a proteínas G.
Only a few animals, such as songbirds, whales, and dolphins, are known to be vocal learners, modifying the sequence or pitch of their sounds based on what they hear from other members of their species. New evidence suggests mice can be added to that list.
HHMI's Robert Lefkowitz shares prize with Brian Kobilka for research on G-protein coupled receptors.
HHMI and the University of KwaZulu-Natal open new research institute in Durban, South Africa.
In experiments with rats, researchers found that the rejection of an old belief correlates with abrupt changes in activity in a region of the brain involved in cognitive functions such as reward anticipation and decision-making.
HHMI selects 13 of the world’s leading basic science researchers to receive Senior International Research Scholar (SIRS) awards. The awards support outstanding biomedical scientists working outside the United States who have made significant contributions to fundamental research in the biological sciences.
HHMI awards three two-year grants to aid in developing the next generation of interdisciplinary scientists, in collaboration with the National Institute of Biomedical Imaging and Bioengineering.
HHMI investigator Ronald D. Vale of UCSF will share the 2012 Albert Lasker Basic Medical Research Award.
Together, the teams include 28 researchers from 20 institutions in the United States, Germany, and Israel.
Thousands of genes in organs throughout the body show predictable daily fluctuations. New research reveals complexity in how those genes' cycles of activity are controlled.
A discovery of how ethylene triggers changes in gene activity could lead to new ways to stop or slow ripening.
Nine students, listed below with their undergraduate institutions, were selected as Gilliam fellows in 2012.
The vaccinia virus increases the size of its genome when it confronts the immune system, thereby increasing the odds of a random mutation that will improve its survival.
By investigating the cause of a fatal snake disease, scientists have found a virus that links two known virus families that can cause fatal hemorrhagic fevers in humans.
Mutations in four different DNA damage repair genes have been linked to chronic kidney disease.
Scientists have catalogued and compared the hundreds of types of bacteria that associate with the roots of the model plant Arabidopsis under various conditions.
HHMI has awarded more than $2 million in fellowships to 50 promising graduate students from 19 countries.
Meet the 2012 International Student Research Fellows
Nurse's lecture on Great Ideas of Biology will take place at HHMIs Janelia Farm Research Campus on July 31.
With a newly discovered component of an adaptive bacterial immune system, scientists have identified a targeted method of slicing DNA that they say can be easily customized for a variety of applications.
Short strands of piwi-interacting RNA may detect foreign invaders by determining whether a gene has ever been turned on in an organism's past.
Quake is being recognized for his work in drug discovery, genome analysis and personalized medicine.
A new imaging technology developed at Janelia lets users track each cell in an embryo as it takes shape over hours or days.
Thirty years after their discovery, scientists have the first picture of a Wnt protein, a member of a protein family that includes some of the most important regulators of growth and development.
HHMI scientists have determined the three-dimensional structure of two proteins that help keep the bodys clocks in sync.