New research indicates individual human neurons may harbor up to 1,000 genetic mutations.
HHMI Investigator Stephen Elledge of Brigham and Women's Hospital shares the 2015 Albert Lasker Basic Medical Research Award with Evelyn Witkin of Rutgers University.
New imaging methods dramatically improve the spatial resolution provided by structured illumination microscopy, one of the best imaging techniques for seeing inside living cells.
HHMI scientists have discovered how the most common genetic defect in amyotrophic lateral sclerosis kills nerve cells.
HHMI researchers solve a longstanding mystery about the origin of new cells in the liver.
A lipid molecule called EET helps blood-forming stem cells replenish the immune system.
New research begins to explain how plants separate microbes they like from those they don't like.
HHMI scientists have profiled key features of the genetic material inside three types of brain cells and found vast differences in the patterns of chemical modifications that affect how the genes in each type of neuron are regulated.
New studies provide the first genetic evidence that humans interbred with Neanderthals in Europe.
New technology developed by HHMI researchers makes it possible to test for current and past infections with any known human virus by analyzing a single drop of blood.
New research hints at strategies fruit flies use to keep track of where they are going, even when it's dark.
Studying fruit fly larvae, Janelia scientists have mapped the entire neural circuit involved in combining vibration and pain sensations used in triggering an escape behavior.
Negative emotions associated with hunger can make it hard to maintain a diet and lose weight. Hunger-sensitive cells in the brain may help explain that struggle.
HHMI researchers develop a new single-cell imaging technique that reveals the copy numbers and locations of thousands of RNA molecules inside a cell.
HHMI researchers identify a rare genetic mutation that tamps down immune response to influenza.
HHMI scientists have designed a revolutionary "3D printer" for small molecules that could open the power of customized chemistry to many.
Scientist at Janelia Research Campus wins The Brain Prize for helping to develop a tool that advances our understanding of how the brain's networks process information.
A new way of thinking challenges standard notions about what a herpes vaccine should look like.
Scientists at Janelia Research Campus have identified a neural circuit that connects motor planning to movement.
A new tool developed at HHMI's Janelia Research Campus lets scientists permanently mark neurons that are active at a particular time.
New studies by HHMI scientists show how cells use sophisticated signaling mechanisms to control production of interferon.
HHMI researchers have identified a neural circuit in the subfornical organ that regulates thirst in mice.
When battling a chronic infection, killer T cells must take a break so they can continue to fight off infection.
Janelia researchers show that Hox proteins trigger gene activity through weak interactions at previously unrecognized DNA binding sites in the genome.
Scientists have determined new structures of an essential cellular recycling machine with near atomic-level detail. The structures, which show a protein called NSF alone and interacting with its target, a protein complex called SNARE that is formed when membranes fuse together.
HHMI scientists and their colleagues discover a new mechanism of protein synthesis.
Researchers at HHMI's Janelia Research Campus have used motion-capture technology to reveal new insight into the sophisticated information processing and acrobatic skills of dragonflies on the hunt.
HHMI investigator Jennifer Doudna is among six scientists honored for transformative advances toward understanding living systems and extending human life.
Lattice light sheet microscopy, a new imaging platform developed at Janelia, lets biologists see 3-D images of subcellular activity in real time.
Janelia group leader Eric Betzig wins Nobel Prize for the development of super-resolved fluorescence microscopy.
Retracing the ancient battles between jumping genes and the defenses human cells deploy to keep them in check.
Janelia scientists are learning how the brain switches between random and strategic modes.
HHMI scientists have shown that previously unrecognized groups contributed to the genetic mix now present in most modern-day Europeans.
HHMI Investigator Sangeeta Bhatia is recognized for designing and commercializing miniaturized technologies with applications to improve human health.
HHMI Investigator Peter Walter of UCSF shares the 2014 Albert Lasker Basic Medical Research Award with Kazutoshi Mori of Kyoto University.
New research by HHMI scientists shows that the emotional memory of an experience is malleable.
Janelia scientists are learning how the brain makes sense of new places.
HHMI scientists have devised a technique to identify hard-to-find gene mutations that crop up in a fraction of the body's cells.
By studying dirty flies, Janelia scientists hope to learn how animals carry out sequences of movements that make up more complex behaviors.
Big data can mean big headaches for scientists. A new library of software tools from Janelia speeds analysis of data sets so large and complex they would take days or weeks to analyze on a single workstation—if a single workstation could do it at all.
Janelia researchers develop a new computational method that can essentially automate much of the time-consuming process of reconstructing an animal's developmental building plan cell by cell.
HHMI and GBMF announce the establishment of an Advanced Imaging Center at Janelia that will make leading-edge imaging technologies more widely available to the scientific community before the instruments are available commercially.
Every millisecond counts when a fruit fly is being hunted by a damselfly. Janelia scientists find that fruit flies can deploy two escape behaviors, depending on circumstances.
HHMI researchers find that a single-letter change in the genetic code is enough to generate blond hair in humans.
HHMI scientists develop new tool to silence neurons with an unprecedented level of control.
Janelia researchers speed up image-processing time and get sharper microscopy images by employing techniques used by astonomers and ophthalmologists.
John P. Donoghue, Director of the Institute for Brain Science at Brown University, will speak on April 30 at 7PM at Janelia.
HHMI researchers have tested the olfactory capacity of human volunteers and found that humans are capable of discriminating at least one trillion different odors.
HHMI researchers show that rising temperatures can cause spread of malaria to areas where the disease had not been endemic historically.
Howard Hughes Medical Institute (HHMI) scientists have created a portrait of a DNA-snipping protein called Cas9, a powerful research tool used in many labs for genome editing.