Three HHMI scientists are among 11 honored for excellence in research aimed at curing intractable diseases and extending human life.
Two studies reveal genetic mutations often present in the most common form of head and neck cancer, offering a picture of how the cancer develops and how therapeutics could treat it.
A new study reveals that many pancreatic tumors take nearly 20 years to become lethal after the first genetic perturbations appear, suggesting an opportunity for early diagnosis.
Most of the clear cell ovarian carcinoma samples examined in a new study carried a gene mutation that alters the epigenetics of cells.
The mitochondrial genome, long thought to be nearly identical in every cell in the human body, actually varies to a surprising degree.
Scientists have detected a multitude of broken, missing, and overactive genes in the most detailed genetic survey yet of any human tumor.
Metastatic colon cancers carry the ability to metastasize from the time they become cancerous, and don't need to acquire any new genetic mutations to become metastatic.
A team of researchers has exposed how one of the genes most commonly mutated in human cancers helps good cells go bad.
New study suggests that each breast and colon tumor is unique and may arise through mutations in many different combinations of genes.
HHMI researchers have found that a typical breast or colorectal tumor results from mutations in about 90 genes.
HHMI researchers have developed a blood test that detects the presence of fragments of mutated genes that are present in colon cancer cells.
HHMI researchers have combed through a catalog of all known tyrosine kinase genes to identify new mutations that occur in a significant fraction of colon cancers.
HHMI researchers uncover evidence of how high-fat diet can promote colon cancer.
According to new studies, 40 percent of patients with colon cancer may have abnormal cell-growth switch.
HHMI researchers develop technique that detects small amounts of colon cancer gene in stool samples.
Better understanding of programmed cell death may improve drug therapy aimed at preventing cancer.
Combining an NSAID with a drug that inhibits epidermal growth factor activity eliminates pre-cancerous colon polyps in mice.
SAGE (serial analysis of gene expression) technology pinpoints genes that build a tumor's nutrient pipeline.
A new laboratory method invented by HHMI investigators and their colleagues improves the accuracy of current genetic diagnostic tests for colon cancer.
Researchers report the first hard evidence that most cases of colon cancer arise when mutations in a genetic "master brake" help to switch on a well-known cancer-promoting gene.
Genes and partial gene sequences are being found at a rate far faster than anyone can decipher their function. Two groups of Hughes researchers have been attacking that bottleneck with automated programs designed to shed light on the function of newly found genes and the expression patterns of known genes.