Researchers gain a new view of how genes are converted to protein by freezing the action during the earliest stage of the process.
A new tool reveals the identity and quantity of every protein produced by a living cell at any given time.
Studies reveal why the same prion protein can be either weakly or strongly infectious.
Sometimes it helps to have a "cheat sheet" when you are working on a problem as difficult as deciphering the relationships among hundreds of thousands of genes.
HHMI researchers discover that brittle prion particles break into new "seeds," which spread infection quickly.
New technique allows scientists to measure the abundance of thousands of proteins with unprecedented resolution.
A new technique for analyzing genetic interactions promises to change how researchers study the dynamic landscape of the cell.
Can randomness in gene expression lead to differences in cells that are genetically identical?
HHMI investigators establish that prions are proteins and they do not require genes or other factors for transmission of their traits.
HHMI researchers redefine the yeast proteome in experiments that meaure the abundance and pinpoint the cellular locations of more than 4,000 proteins.
HHMI researchers have shown that mutations in yeast prions can affect their ability to infect different strains of yeast.
New research suggests that knowledge of the shape of a prion is critical to understanding which hosts it can infect.