By activating regions of the brain linked to food-related pleasure, scientists are learning how the brain mediates the link between food preferences and hunger.
Jeffrey Friedman and Douglas Coleman are being honored for discoveries that led to the identification of leptin, a hormone that regulates appetite and body weight.
New studies show that the appetite-regulating hormone leptin causes rewiring in areas of the brain that regulate feeding behavior.
HHMI researchers discover a metabolic switch that appears to tell the body to store or burn fat.
HHMI researchers have devised a clever technique to map the neural circuitry that governs food intake.
Researchers identify protein that detects a cell's total salt concentration.
Investigadores identifican una proteína que detecta la concentración salina total de una célula.
HHMI researchers obtain detailed portrait of genetic program induced by leptin.
Investigadores del HHMI obtienen una detallada descripción del programa genético inducido por la leptina.
Jeffrey M. Friedman and colleagues report that the weight-reducing effects of the hormone leptin result from interaction with a receptor in the brain's hypothalamus and other tissues.
Leptin administered to overweight mice during two weeks of treatment caused the mice to decrease food intake and increase energy expenditure.
HHMI researchers at Rockefeller University have discovered a new hormone produced by fat tissue and presumably acting on the brain to regulate weight.