HHMI researchers have designed an inhibitor that can reduce the expression of the mutated gene that causes hypertrophic cardiomyopathy, a potentially fatal heart condition.
New research shows that about 10 percent of severe cases of congenital heart disease are caused by genetic mutations that are absent in the parents of affected children.
Defectos en el gen que codifica para la proteína más grande del cuerpo humano son responsables de más casos de la enfermedad que los causados por todas las otras mutaciones conocidas.
Defects in the gene that encodes the human body’s largest protein are responsible for more cases of dilated cardiomyopathy than are caused by all other known mutations associated with the heart disorder.
New clues narrow the search for the underlying cause of a serious congenital heart defect.
Identifying the complete set of genes whose activity is altered by disease used to appear impossible. Not anymore.
HHMI researchers have discovered how an inherited disorder disrupts the flow of calcium in heart muscle cells.
Investigadores del HHMI han descubierto la forma en la que un trastorno hereditario interrumpe el flujo del calcio en las células del músculo cardíaco.
HHMI researchers have identified a gene that influences formation of the chambers of the heart.
Familial hypertrophic cardiomyopathy is the most common underlying cause of sudden cardiac death in young athletes. New research suggests the disorder may be more widespread than previously thought.
Christine and Jonathan Seidman have developed a mouse model of familial hypertrophic cardiomyopathy that should greatly enhance genetic studies of this deadly disease.