Long, ropy fibers were long thought to be the causes of these diseases including Alzheimer's and Parkinsons, but research over the past decade has revealed that fibers arent amyloid proteins' most toxic form.
Researchers have found the key factors that cause proteins to turn into sticky, fibrous clumps that can grind cellular activity to a halt.
Variations in the ways abnormal proteins fit together to form the long amyloid fibrils associated with many diseases may represent a protein-based system of inheritance that parallels the genetic code.
HHMI researchers pioneer a new approach to determining the structure of protein complexes.
HHMI researchers have provided the first detailed look at the spine of amyloid, the abnormal protein filaments found in at least 20 devastating diseases, ranging from Alzheimer's to Creutzfeldt-Jakob disease.
Investigadores del HHMI han proporcionado la primera imagen detallada de la estructura del núcleo de los filamentos proteicos anormales que se encuentran en por lo menos 20 enfermedades devastadoras, que van desde Alzheimer hasta la enfermedad de Creutzfeldt-Jakob.