The first unbiased genetic screen for sleep defects in mice yields two interesting mutants, Sleepy, which sleeps excessively, and Dreamless, which lacks rapid eye movement sleep.
Thousands of genes in organs throughout the body show predictable daily fluctuations. New research reveals complexity in how those genes' cycles of activity are controlled.
HHMI scientists have determined the three-dimensional structure of two proteins that help keep the body's clocks in sync.
Cellular clocks throughout the body are precisely synchronized by tiny fluctuations in body temperature.
A newly identified gene mutation in mice has revealed how the molecular oscillations behind circadian rhythms are kept on track.
The Clock gene, widely appreciated as a driver of circadian rhythms, aids in regulating the brains reward circuitry, which is triggered by cocaine and other addictive drugs.
The clock genes that govern circadian rhythms also function in similar cycles in peripheral cells outside the brain.
Los genes del reloj que gobierna los ritmos circadianos también funcionan en ciclos similares en células periféricas que se encuentran fuera del cerebro.
Pinpointing the cause of a mutation that switches a hamster's biological clock to a 20-hour day.
Identificación de la causa de una mutación que lleva al ciclo del reloj biológico de un hámster a 20 horas diarias.
hedding Light on Circadian RhythmsTwo teams of HHMI researchers and their collaborators have found what may be the missing molecular link between sunlight and the circadian clock.
eCircadian clocks maintain the sleep-wake cycle for a 24-hour day in a variety of organisms. Two HHMI researchers and their colleagues have discovered more of the clock's molecular components.