HHMI investigators Stephen Elledge, Roel Nusse and Huda Zoghbi are among the scientists honored for transformative advances toward understanding living systems and extending human life.
Zoghbi shares Shaw Prize for research leading to discovery of genes and proteins involved in Rett syndrome.
Identification of a cell signaling pathway that affects the levels of the toxic protein responsible for the neurodegenerative disease SCA1 could lead researchers to new drugs.
A new study has pinned some of the symptoms of Rett syndrome to a set of neurons that usually work to rein in nerve cell firing in the brain.
HHMI researchers have identified a new factor necessary for the development of medulloblastomas, the most common type of malignant childhood brain cancer.
Scientists have discovered that the mutation that causes Rett syndrome interferes with the regulation of 2,500 other genes.
Researchers studying spinocerebellar ataxia have uncovered a pathological mechanism that may also underlie more common neurological diseases.
Huda Zoghbi, an HHMI researcher at Baylor College of Medicine, will deliver a public lecture on "The Path to Understanding and Treating Neurological Diseases" on Tuesday, September 18, 2007.
Studies in mice show that lithium can ease the symptoms of spinocerebellar ataxia type 1, an inherited neurodegenerative disorder.
A new resource will speed understanding of inherited disorders that kill cells in the brain.
HHMI researchers studying the childhood neurological disorder Rett syndrome have discovered a new clue about how the disorder can cause a devastating range of symptoms.
Researchers have discovered how the abnormal repetition of a genetic sequence can have disastrous consequences that lead to the death of neurons that govern balance and motor coordination.
HHMI researchers have developed a mouse model of the leading cause of mental retardation in girls.
Investigadores del HHMI han desarrollado un modelo en ratón de la causa principal de retraso mental en niñas.
Studies of mice with spinocerebellar ataxia type I, a neurodegenerative disease, pinpoint abnormalities in gene expression that occur long before signs of the disease appear.
Desmenuzando las etapas tempranas de la neurodegeneración Estudios de ratones con ataxia espinocerebelosa tipo I, una enfermedad neurodegenerativa, indican la existencia de anormalidades en la expresión génica que ocurren mucho antes de que los signos de la enfermedad aparezcan.
A 14-year search for the genetic mutations that trigger a neurodegenerative disease has ended.
HHMI researchers discover a gene responsible for triggering embryonic cells in the inner ear to develop into sound- and motion-sensing hair cells.