For some developmental genes, one allele must stay silent, otherwise debilitating syndromes and cancers can arise. HHMI Investigator Yi Zhang and his colleagues have uncovered a new imprinting mechanism cells use to keep these genes quiet in mice.
Scientists at HHMI’s Janelia Research Campus created comprehensive brain maps linking different groups of neurons to specific behaviors, using a machine-learning program that annotated more than 225 days of videos of flies – a feat that would have taken humans some 3,800 years.
Janelia Research Campus scientists have uncovered new clues about how fruit flies keep track of where they are in the world. Understanding the neural basis of navigation in flies may reveal how humans accomplish similar feats.
In studies with mice, Janelia researchers discovered that to maintain certain short-term memories, the brain’s cortex relies on connections with the thalamus.
Hypoxia reverses brain damage caused by mitochondrial dysfunction, HHMI team finds. The approach might one day point to new therapies for people with Leigh syndrome and other mitochondrial disorders.
New HHMI research reveals that adding or deleting chromosomes in cells and animals prompts a wide variety of outcomes. The work could help scientists better understand chromosomal abnormalities in humans.
HHMI Investigator Huda Zoghbi is one of seven scientists honored with prestigious awards from Canada's Gairdner Foundation.
New research adds to growing evidence that Parkinson's disease may arise in part from neurons’ failure to recycle the materials used to package and transport neurotransmitters.
HHMI scientists develop a much-needed genetic resource that is aiding development of wheat plants with improved traits.
HHMI investigators Stephen Elledge, Roel Nusse and Huda Zoghbi are among the scientists honored for transformative advances toward understanding living systems and extending human life.
HHMI researchers identify the mechanisms that pathogenic bacteria use to waterlog the space between plant cells in the leaves, allowing the bacteria to reproduce and spread infection.
Janelia scientists have developed the first adaptive light-sheet microscope — an instrument that continuously analyzes and adapts to dynamic changes in a specimen and thereby improves spatial resolution.
HHMI researchers find that a gene that blocks the differentiation of pigment-producing cells in the skin of the African striped mouse helps in generating the mouse’s characteristic light-colored stripes.
The first unbiased genetic screen for sleep defects in mice yields two interesting mutants, Sleepy, which sleeps excessively, and Dreamless, which lacks rapid eye movement sleep.
Janelia scientists are learning how animals adjust their physical exertion as changes in the environment or their own bodies alter how efficiently they move.
A new viral vector will help scientists understand large-scale neural networks.
HHMI researchers have learned to program T cells as if they were "microscopic robots" -- to sense inputs and to respond.
Lasker Award honors research showing how cells from humans and most animals sense and adapt to changes in oxygen availability.
Janelia scientists have identified a gene that causes male Drosophila to produce different courtship songs.
Using novel computational and biochemical approaches, HHMI scientists have designed and built from scratch 10 large protein icosahedra that are similar to viral capsids that carry viral DNA.
International research team unveils new data describing the interaction between genetic and epigenetic variation in Arabidopsis thaliana.
Janelia scientists find that a molecule best known for its role in pain perception also plays an important role in regulating body weight.
HHMI scientists have pioneered the use of genome editing to trace lineage in living systems.
Researchers have discovered that fat tissue is a previously unrecognized reservoir of trypanosomes, the parasites that cause sleeping sickness.
HHMI scientists have designed a potential cancer therapy that uses a unique strategy to block a molecule that drives the growth of cancer.