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Jim Keeley
(301) 215-8858
keeleyj@hhmi.org
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March 21, 2005
2005 New Investigators
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Susan L. Ackerman

Susan L. Ackerman, Ph.D.
Staff Scientist
Jackson Laboratory
Bar Harbor, ME
Genetics, Neuroscience

Susan L. Ackerman is working to identify and analyze the genes, pathways, and networks involved in age-related death of neurons in the central nervous system. Moresmall arrow
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James Bardwell

James Bardwell, Ph.D.
Associate Professor of Molecular, Cellular, and Developmental Biology
University of Michigan
Ann Arbor, MI
Genetics

James Bardwell studies protein-folding catalysts and chaperones—the critical molecular machines that help proteins shape up. Bardwell focuses on disulfide bonds, which act like bolts or stiffening struts for folding proteins. Moresmall arrow
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David P. Bartel

David P. Bartel, Ph.D.
Professor of Biology
Massachusetts Instiute of Technology
Cambridge, MA
RNA Biology, Biochemistry

David Bartel explores how RNA molecules can act as catalysts and regulate gene expression in plant and animal cells. Moresmall arrow
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Bonnie L. Bassler

Bonnie L. Bassler, Ph.D.
Professor of Molecular Biology
Princeton University
Princeton, NJ
Microbiology, Genetics

Bonnie L. Bassler studies the molecular mechanisms that bacteria use to communicate with one another, with an eye toward combating deadly bacterial diseases and understanding cell signaling in humans. Moresmall arrow
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Albert Bendelac

Albert Bendelac, M.D.,Ph.D.
Professor of Pathology
The University of Chicago
Chicago, IL
Immunology

Albert Bendelac pursues two areas of investigation: the biochemistry and cell biology of lipid antigens involved in immunity and the biology of T cells that recognize these lipid antigens. These studies may have medical applications for a range of immune-related diseases. Moresmall arrow
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Ronald R. Breaker

Ronald R. Breaker, Ph.D.
Professor of Molecular, Cellular, and Developmental Biology
Yale University
New Haven, CT
Genetics, RNA Biology

Ronald Breaker is discovering how RNA and DNA molecules catalyze reactions and control gene activity in the cell and is artificially evolving molecules that could be used in industry and medicine. Moresmall arrow
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Andrew Camilli

Andrew Camilli, Ph.D.
Associate Professor of Molecular Biology and Microbiology
Tufts University School of Medicine
Boston, MA
Microbiology, Genetics

Andrew Camilli is working to determine how two bacterial pathogens—Vibrio cholerae, which causes cholera, and Streptococcus pneumoniae, a major cause of pneumonia and otitis media—become so virulent. Moresmall arrow
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Edwin R. Chapman

Edwin R. Chapman, Ph.D.
Associate Professor of Physiology
University of Wisconsin-Madison
Madison, WI
Neuroscience

Edwin R. Chapman is deciphering the structure and dynamics of fusion pores, key components of exocytosis. Using a broad toolkit, he has developed an experimental system that reconstitutes membrane fusion at the lab bench. Moresmall arrow
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Zhijian Chen

Zhijian Chen, Ph.D.
Associate Professor of Molecular Biology
The University of Texas Southwestern Medical Center at Dallas
Dallas, TX
Biochemistry, Immunology

Zhijian “James” Chen’s work is aimed at understanding the mechanisms and pathways of ubiquitin signaling, particularly with regard to its role in immunity and cancer. Moresmall arrow
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Joseph DeRisi

Joseph DeRisi, Ph.D.
Gordon Tomkins Chair of Biochemistry and Biophysics
University of California, San Francisco
San Francisco, CA
Genetics, Microbiology

Joseph DeRisi is applying the latest genomic technology, such as DNA microarrays, to detect unknown viruses and explore the genetic machinery of malaria, to develop new treatments. Moresmall arrow
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Sascha du Lac

Sascha du Lac, Ph.D.
Hearst Endowment Associate Professor, Systems Neurobiology
The Salk Institute for Biological Studies
La Jolla, CA
Neuroscience

Sascha du Lac is using a range of scientific techniques to understand how experience alters the neural pathways that are involved in learning. Moresmall arrow
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Michael D. Ehlers

Michael D. Ehlers, M.D., Ph.D.
Associate Professor of Neurobiology
Duke University Medical Center
Durham, NC
Neuroscience, Biochemistry

Michael Ehlers is exploring how brain cells constantly adapt to their changing environment, maintaining neuronal contact sites and storing information at a molecular level. His goal is to understand how cellular processes that emerged in simpler cells work in the scaled-up, specialized milieu of the neuron. Moresmall arrow
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Evan E. Eichler

Evan E. Eichler, Ph.D.
Associate Professor of Genome Sciences
University of Washington
Seattle, WA
Genetics, Computational Biology

Evan Eichler focuses on the role of duplicate regions in the human genome. Using computational and experimental approaches, he investigates the architecture of these regions and their role in evolution and disease. Moresmall arrow
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K. Christopher Garcia

K. Christopher Garcia, Ph.D.
Associate Professor of Microbiology and Immunology and of Structural Biology
Stanford University
Palo Alto, CA
Structural Biology, Immunology

K. Christopher Garcia is investigating structural and functional aspects of cell surface receptor recognition and activation, focusing on receptors that are relevant to human health and disease. Moresmall arrow
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Taekjip Ha

Taekjip Ha, Ph.D.
Associate Professor of Physics
University of Illinois at Urbana-Champaign
Urbana, IL
Biophysics

Taekjip Ha uses sophisticated physical techniques to manipulate and visualize the movements of single molecules to understand basic biological processes involving DNA and other molecules. Moresmall arrow
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Gregory J. Hannon

Gregory J. Hannon, Ph.D.
Professor
Cold Spring Harbor Laboratory
Cold Spring Harbor, NY
RNA Biology, Cancer Biology

Gregory J. Hannon’s research program seeks to understand the biology of RNA interference and to find novel therapeutic approaches for human cancer. Moresmall arrow
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Oliver Hobert

Oliver Hobert, Ph.D.
Assistant Professor of Biochemistry and Molecular Biophysics
Columbia University College of Physicians and Surgeons
New York, NY
Neuroscience, Genetics

Oliver Hobert studies molecular mechanisms that create and maintain cellular diversity in the nervous system. Moresmall arrow
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Linda C. Hsieh-Wilson

Linda C. Hsieh-Wilson, Ph.D.
Assistant Professor of Chemistry
California Institute of Technology
Pasadena, CA
Neuroscience, Biochemistry

Linda Hsieh-Wilson is integrating organic chemistry with neurobiology to understand how key carbohydrates and their various derivatives alter the structure and function of proteins in the brain. In particular, she is investigating the molecular events underpinning protein glycosylation, which may be critical to cellular communication. Moresmall arrow
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Steven E. Jacobsen

Steven E. Jacobsen, Ph.D.
Professor of Molecular, Cell, and Developmental Biology
University of California, Los Angeles
Los Angeles, CA
Genetics

Steve Jacobsen studies the genetics of DNA methylation and gene silencing in the plant Arabidopsis. Moresmall arrow
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Erik M. Jorgensen

Erik M. Jorgensen, Ph.D.
Professor of Biology
University of Utah
Salt Lake City, UT
Neuroscience, Genetics

Erik M. Jorgensen uses genetics and cell biology in C. elegans to address fundamental questions about the function of neuronal synapses. Moresmall arrow
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Dorothee Kern

Dorothee Kern, Ph.D.
Associate Professor of Biochemistry
Brandeis University
Waltham, MA
Biochemistry

Dorothee Kern uses biophysical analytical techniques to unravel the dynamic personality of enzymes, signaling proteins, and the molecules they affect. Moresmall arrow
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Alex Kolodkin

Alex Kolodkin, Ph.D.
Professor of Medicine (Neuroscience)
The Johns Hopkins University
Baltimore, MD
Neuroscience

Alex Kolodkin is learning how proteins act as “guidance cues” for growing nerves, alternately repelling and attracting growth to keep a developing nerve on the right track inside the body. Moresmall arrow
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