Lecture 2: Adult Stem Cells and Regeneration
by Nadia Rosenthal, Ph.D.
Play Lecture Two in Full
Welcome by HHMI Vice President Dr. Peter Bruns
Dr. Nadia Rosenthal in the lab
Overview of differentiation
Replenishment and renewal of the body
Some cells replenish constantly
Replenishment vs. regeneration
The myth of Prometheus and liver regeneration
Is wound healing regeneration?
Stem cells are rare in adults
Some animals can regenerate body parts
Planaria regeneration and stem cells
Student experiments on planaria regeneration
Stem cells activated in regenerating planaria
Demo: The fire-bellied newt
Animation: Newt limb regeneration
Muscle cells contribute to skin in regenerating limb
Can humans regenerate body parts?
Q&A: Why can't the newt arm grow a new newt?
Q&A: Could you put newt stem cells into a human?
Q&A: What happens to muscle in limb lengthening?
Q&A: Can a newt regenerate its organs?
Q&A: How many times will the newt limb regenerate?
Q&A: What triggers cells to form the blastema?
Problems with mammalian regeneration
Dedifferentiation of cells during regeneration
Cancer and dedifferentiation are similar
Controlled cell proliferation in the newt
Are regenerative genes lost in higher organisms?
Identifying the signals that control limb regrowth
The CD59 protein may guide newt limb regrowth
Overexpressing CD59 causes malformation
Demo: Regeneration of deer antlers
Adult stem cells in bone marrow and muscle
Muscular dystrophy overwhelms stem cell capacity
Using bone marrow cells to repair dystrophic muscle
Growth factor IGF-1: Function and mechanism
IGF-1 improves bone marrow's ability to regrow muscle cells
Summary of regeneration schemes
Q&A: Could stem cells reverse the effects of liver cancer?
Q&A: Why do we age if we can regenerate cells?
Q&A: How far up a newt's limb can you cut?
Q&A: Are skin markings identical on the regrown newt limb?
Q&A: Can a newt regrow two limbs at once?
Closing remarks by HHMI Vice President Dr. Peter Bruns