Lecture 3: Human Genetics: A New Guide for Medicine
by Eric S. Lander, Ph.D.
Play Lecture Three in Full
Introduction by HHMI Vice President Dr. Peter Bruns
Introductory interview with Dr. Eric Lander
Observing what nature has already perturbed
How similar are the two copies of your DNA?
How similar is DNA from two different people?
Human origins and why we have little genetic variation
Tracing human migrations by looking at genetic variation
What differences do genetic variations make?
Single nucleotide polymorphism (SNP) can affect Alzheimer disease
Other examples of variations affecting diseases
Some mutations can protect against AIDS
Cataloging all human variations
Filling in life's matrix: Genes, phenotypes, and SNPs
Examples of genetic bases of human phenotypic variation
Can "Olympic gold medalist" be a phenotype with a genetic basis?
Q&A: Are mutation rates different in different species?
Q&A: Has the mutation rate increased with a larger human population?
Q&A: Would alcohol digestion problems affect alcoholism?
Measuring variations in the levels of all RNA expressions
Can differences in leukemias be detected by microscopy?
The discovery of two kinds of leukemia: AML and ALL
Limitations of conventional leukemia diagnostic methodologies
How to make a DNA microarray
Using microarrays to detect the activities of all genes in a tumor
Using microarrays to differentiating AML and ALL
Using computers to sort RNA expression data
Discovering a novel type of leukemia
Building the taxonomy of tumors, as well as other biological functions
Q&A: How accessible is the microarray technology to doctors?
Q&A: Are some mutations inherently bad and selected against?
Q&A: Wouldn't DNA variation confound the microarray detector mechanism?
Q&A: Are DNA microchips reusable?
Closing remarks by HHMI Vice President Dr. Peter Bruns