BROWSE ALL RESOURCES
VIEW ALL
BY TYPE
Animation (3) Book/Manual (4) CD (1) Classroom Activity (12) College Course (6) Curriculum (11) Game (1) Kit (1) Lab (9) Lesson Plan (5) Publication (23) Software (3) Tutorial (5) Video (24) Website (47) Wiki (2)BY TOPIC
Biochemistry (14) Biodiversity (3) Bioengineering (3) Bioethics (3) Bioinformatics (8) Biology (104) Biotechnology (9) Cell Biology (3) Chemistry (17) Earth Science (1) Ecology (9) Engineering (1) Evolution (10) General Science (15) Genetics (29) Genomics (13) Immunology (2) Infectious Diseases (1) Life Science (65) Mathematics (9) Medicine (6) Microarrays (5) Microbiology (3) Molecular biology (34) Neuroscience (7) Physics (5) Plants (2) Professional Development (35) Research methods (12) Science Communication (2) Systems Biology (1)BY GRADE LEVEL
K-16 (1) 4-8 (1) K-5 (6) Medical School (6) K-3 (2) K-8 (2) K-12 (9) 6-8 (18) 9-12 (52) College (101) Graduate (21)
Protein Secretion and Vesicle Traffic Video Lecture
In this video lecture, HHMI Investigator Randy Schekman, Ph.D., explains the secretory pathway, which all cells use to deliver proteins, lipids, and other molecules to different parts of the cell and outside the cell. It is involved in everything from cell surface growth to the construction of organelles. Studies using genetics and biochemistry have revealed that the mechanisms of this process are conserved among all organisms, particularly eukaryotes. Defects in this process underlie many human diseases. In Part 1, “Studying Protein Secretion in Yeast,” Dr. Schekman explains how using genetics in Saccharomyces cerevisiae (Baker’s yeast) allowed scientists to dissect the secretory pathway in all eukaryotic cells. This section of the lecture is suitable for undergraduates. In Part 2, “Biochemical Reconstitution of Transport Vesicle Budding,” he describes how protein biochemistry provides additional information to explain how secretory vesicles are formed and fuse with other membranes. This lecture focuses on the in vitro reconstitution of transport between the endoplasmic reticulum and the Golgi apparatus. Part 2 is appropriate for advanced undergraduates or graduate students. In Part 3, Dr. Schekman discusses his more recent experiments, explaining how basic science and medicine converged when a mutation in the Sec23 protein was identified as the cause of a rare human craniofacial disease. Part 3 is aimed at graduate or medical students. Teaching tools include four short video clips, lecture notes, review and facilitator questions, a feature called “Explain/teach these concepts to a friend,” and recommended reading. To view answers to the review and facilitator questions, educators must register on the site as teachers. Users studying on their own should send an email to ibioseminars@cmp.ucsf.edu with a request for the answers. This seminar is featured at iBioSeminars, which offers a series of free video talks by leading biologists, with accompanying educational materials.
Secretory Vesicle Fusion in Yeast
This short clip, one of four available for classroom use, displays electron micrographs of budding yeast cell showing secretory vesicles fusing with the plasma membrane in a manner similar to that seen in nerve cells.
Media: Quicktime