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Cell-to-Cell Communication in Bacteria Video Lecture
In this lecture, HHMI Investigator Bonnie Bassler, Ph.D., explains how bacteria, primitive single-celled organisms, communicate with chemical languages that allow them to synchronize their behavior and thereby act as enormous multi-cellular organisms. This process, called quorum sensing, enables bacteria to successfully infect and cause disease in plants, animals, and humans. Dr. Bassler describes how investigations of the molecular mechanisms underlying quorum sensing are leading to the development of novel strategies to interfere with quorum sensing. These strategies form the basis of new therapies to be used as antibiotics. Teaching tools for the lecture—which is suitable for upper-level undergraduates—include the speaker’s biography, lecture notes, review and facilitator questions and answers, recommended reading, and PDFs of all materials. This lecture is part of the iBioSeminars series of talks by many of the world’s leading biologists, with accompanying educational materials.
Quorum Sensing in V. cholerae
After an introduction to the topic of bacterial communication, Bonnie Bassler focuses on the unique quorum sensing mechanism in Vibrio cholerae, which, upon infecting its human host, immediately initiates expression of virulence genes and causes an acute infection. This process provides an opportunity to explore strategies in which quorum sensing autoinducer molecules are supplied to treat bacterial infections.
Media: Quicktime