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Point of Care Diagnostics for the Developing World Video
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This hour-long video from the University of Washington’s Molecular Medicine Training Program explains microfluidics—a technology for manipulating small volumes of fluid that could have a major impact on global health by enabling the development of a portable and inexpensive system for detecting pathogens. In his talk, originally presented as a public lecture for a local audience, including high school students, Dr. Paul Yager, Professor and Chair of the Department of Bioengineering, first describes the principles of microfluidics and several microfluidic technologies (such as an H-filter, that can extract small molecules from complex mixtures without the need for a physical filter). Next, he explains why portable, convenient, and accurate tools that rapidly deliver test results to doctors and patients are important for the developing world, where complex, expensive, and centralized laboratory equipment is often difficult to use and maintain. Dr. Yager concludes his talk with a description of a point-of-care diagnostic system that he and a team of collaborators are currently developing—the Dx (Diagnostics) Box, a low-cost, easy-to-use device that will rapidly test blood for a range of health problems prevalent in developing countries. Using a drop of two of blood as a sample, the Dx Box will allow differential diagnosis of six causes of rapid-onset fevers (such as malaria and dengue) that infect tens of millions of people each year. The UW Molecular Medicine Training Program’s website also contains videos of other public science lectures, with new videos added as lectures take place.
The Dx Box
The Dx (Diagnostics) Box described in this video lecture is a medical device that could have an impact on global health by delivering quick and accurate test results to doctors and patients.
Program Director: Nancy Maizels, Ph.D.
Award Years: 2006
Summary: The University of Washington is a public research university in Seattle, Washington. Its Molecular Medicine Training Program, funded by HHMI's Med into Grad Program, provides Ph.D. students with training that integrates fundamental principles of biology with human health and disease. The program incorporates three key elements: case-based courses, a clinical rotation in human genetics or a medical pathology course, and dual mentorship of Ph.D. research by a basic scientist and a clinically trained or clinically oriented research scientist.