Job Type:
Laboratory/Research
Employment Category:
Full Time (40 hours/week)
Location:
Univ of Michigan
Ann Arbor, Michigan
Job Number:
001827-003
Posted On:
03/06/2012
Reports To:
Friedhelm Hildebrandt, MD
Investigator
Research Abstract
Job Summary:
Howard Hughes Medical Institute, a leading biomedical research organization, is recruiting a highly motivated biostatistician to apply algorithms for the evaluation of whole human genome and exome sequencing (NextGen sequencing) to the identification of Mendelian disease genes in humans. The laboratory of Friedhelm Hildebrandt, MD (Investigator, Howard Hughes Medical Institute) focuses on the identification of novel disease genes mutated in diseases of kidney, eye and ear and their functional characterization, to understand the disease mechanisms involved and to develop new therapies.
Please note: The successful applicant will start in the investigator’s lab at the University of Michigan and would follow the Investigator on March 1, 2013 to his new lab at the Boston Children’s Hospital/Harvard.
Principal Responsibilities:
- Experience with the use and development of bioinformatics pipelines for the analysis of whole human genome or exome sequencing with a solid background in computational biology/biostatistics.
- Work within a team of postdoctoral research fellows within ongoing projects of disease gene identification.
- Use and improve algorithms of NextGen sequence evaluation for deleterious disease-causing alleles (SNPs, indels, CNVs) in Mendelian disorders.
- Interact with colleagues and graduate students in the lab as well as occasional IT maintenance in collaboration with the strong existing IT support. There are ample opportunities of interactions with bioinformaticians in the Department of Human Genetics, the Center for Computational Medicine and Bioinformatics (CCMB), and the School of Public Health at the University of Michigan.
Preferred Qualifications:
- M.S. or higher, in a related field and experience in the field are a requirement for this position.
- Excellent personal and communication skills and the ability and desire to interact with a team of scientists in the lab and beyond are essential.
- Strong background is necessary in one or more of the following areas: bioinformatics, biostatistics, programming (e.g., R, C, Perl, Java) and other IT skills.
- Some lab experience in genetics or molecular biology is helpful as well as qualifications in web-based user interface development and database management.
Additional Information:
HHMI offers a competitive salary as well as a generous and flexible benefits package.
Interested candidates should send a single PDF with updated CV, names of two references, and a cover letter describing your specific qualifications and interests to Friedhelm Hildebrandt, M.D. at fhilde@umich.edu. Please include the job title in the subject line.
To Apply:
To apply for this position, please email your resume to:
Friedhelm Hildebrandt, MD
Investigator
Professor of Pediatrics and of Human Genetics
Investigator, Howard Hughes Medical Institute
1150 West Medical Center Drive
8220C MSRB III
Ann Arbor, Michigan 48109-0640
Email: fhilde@umich.edu
Application Deadline:
Open Until Filled
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