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MOVIES
>> Take a walk with the two-motor domain kinesin protein as it moves stepwise along the cellular roadway known as a microtubule. Microtubule binding energy and a second energy source, ATP, fuel kinesin as it repeatedly slings its rear "foot" around to take the lead position, moving the molecule along in a ratcheted manner. >> VISIT
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For dramatic movies of axon traffic jams in fly larvae, see the Supporting Online Material section
of this paper:
Gorazd B. Stokin, Concepción Lillo, Tomás L. Falzone, Richard G. Brusch, Edward Rockenstein, Stephanie L. Mount, Rema Raman, Peter Davies, Eliezer Masliah, David S. Williams, and Lawrence S. B. Goldstein Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer's Disease, Science, Vol. 307, Issue 5713, 1282-1288, 25 February 2005.
>> www.sciencemag.org (subscription or per-article purchase required)
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PHOTOS
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To see vivid still images of kinesins, see this paper...
Ronald D. Vale and Ronald A. Milligan. The Way Things Move: Looking Under the Hood of Molecular Motor Proteins. Science, Vol. 288, Issue 5463, 88-95, 7 April 2000.
>> www.sciencemag.org (subscription or per-article purchase required)
>>
...and this paper:
Ahmet Yildiz, Michio Tomishige, Ronald D. Vale, Paul R. Selvin, Kinesin Walks Hand-Over-Hand, Science, Vol. 303, Issue 5658, 676-678, 30 January 2004.
>> www.sciencemag.org (subscription or per-article purchase required)
>>
See also the lab site for the Ronald Vale lab.
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