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The cool tile looked the same as the rest of the floor, so the only landmarks in the arena were patterns of bars projected on the wall. To determine whether the flies used this background to guide them to the cool tile, the researchers rotated the floor and walls of the arena after each trial so that the location of the cool floor tile changed, but its position relative to the wall patterns stayed the same.
The flies quickly learned to pinpoint the cool spot. After 10 attempts, the insects could find the tile in under 60 seconds, less than half the time of their first try, the group reported June 8, 2011, in Nature. Moreover, when the trained flies encountered an arena without a cool tile, they congregated where the tile should have been, based on the visual background.
Then the team tricked the flies, rotating the thermal pattern on the arena floor after each trial but leaving the wall stationary, so that the background pattern no longer corresponded to the location of the cool tile. The flies were baffled. When given the chance to find the cool tile in the dark, they also made no headway. Given this evidence, the researchers concluded that “flies can form memories about spatial locations,” says Ofstad.
Next the researchers wanted to know which part of the fly brain remembers the location of the cool spot. They switched off certain brain cells in the flies, using genetic tools developed in the lab of Janelia Farm director Gerry Rubin that allow scientists to target small groups of identified neurons. When neurons in a structure called the ellipsoid body were shut down, the flies couldn’t navigate the arena. Thus, this structure might be crucial for storing or retrieving spatial information in the insects. The role of the ellipsoid body isn’t clear, but Zuker says it would be the first place to look for the fly equivalent of place neurons.
The researchers have gone their separate ways—Ofstad has returned to San Diego to finish clinical work for his M.D., and Zuker has moved his lab to the Columbia University College of Physicians and Surgeons in New York City. The team, however, is hatching a plan to use fruit fly vision and behavior to decipher another aspect of brain function. “When you find the unique synergy that helps some of the magic come out of exciting scientific problems, you want more of it,” Zuker says. 
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Visitors Welcome
There’s nothing extraordinary about a scientist like Charles Zuker working in a collaborator’s lab. However, there’s very little that’s ordinary about the Janelia Farm Visitor Program.
“I think the visitor program is a unique and inspired concept, and JFRC is an ideal location,” says Robert Singer of the Albert Einstein College of Medicine, one of the research campus’s first visiting scientists. “It allows groups to come together to focus on a scientific problem, free from the usual distractions that interfere with concentrated problem solving. All the amenities and resources are there to facilitate research collaborations.”
Even when Janelia Farm was just a big idea on a little napkin, visiting scientists were an integral part of the concept. In fact, the original proposal for the establishment of Janelia Farm submitted to the HHMI Trustees in August 2000 states, “There is currently no well-equipped laboratory facility in the world where a group of scientists can come to work together, each bringing a few members of their research group, for periods ranging from a few weeks to a few years.”
“It provides an important and valuable contribution to the community that really couldn’t be done anywhere else,” says Singer.
The visitor program started as a way for scientists from other labs to come and use the site’s facilities. One hundred and fifty-six researchers from 16 countries have taken part in the highly flexible program since it was launched in 2006. Janelia can host up to 100 visiting scientists at a time. Each gets lab and office space, access to shared facilities, and, if desired, on-site housing. Scientists can stay for a few days or a few years. They can be in-residence full time, or they can have a few of their lab members in-residence while they work part time at Janelia. Visitors can come to collaborate with a specific Janelia scientist or to use specialized equipment that they don’t have at their own institution.
The program is distinctive because it includes students and postdocs—the people who might benefit most from a new lab experience—as visitors. Take Misha Ahrens, a graduate student from University College of London. Ahrens spent seven months at Janelia working with group leaders Michael Reiser and Vivek Jayaraman, then a fellow, developing tools to monitor neuronal activity in fruit flies.
While most visitors are nominated by Janelia Farm lab heads, any scientist in academia or industry who wants to spend time at Janelia is encouraged to apply. All that is asked is that visitors actively participate in Janelia’s collaborative atmosphere during their stay. -- Nicole Kresge
Janelia Visitor Program: Current Stats
52
active visitor projects
22
Janelia Farm lab head hosts
110
visiting scientists
47
international visiting scientists
16
foreign countries represented
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