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FEATURES
Carving Out Her Niche

  By David J. Tenenbaum

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Microscope-hopping through her biochemistry lab at the University of Wisconsin-Madison, Judith Kimble shows off plates holding <i>Caenorhabditis elegans</i>, the nematode that jump-started her career. In some plates, glowing blotches of green fluorescent protein draw attention to different structures within the living worms. At the last microscope, the glow is concentrated on one particular cell, a sock-shaped giant located toward the center.

This cell, which Kimble named the “distal tip cell,” turned out to have astonishing powers. In the distal tip cell, Kimble made the first discovery of a “stem-cell niche,” a specialized biochemical environment that controls stem-cell fate.

Photo: Kevin Miyazaki

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