We're also proceeding with a bold collaboration—with the KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH)—that will bring together HHMI investigators and scientists from South Africa in a program of research in the heart of the entwined epidemics of tuberculosis and HIV. You can read more about K-RITH and our partners in this issue of the HHMI Bulletin. This initiative is incredibly interesting and somewhat risky—but if we succeed, it will be a home run. Indeed, HHMI's strength depends on its ability to remain nimble, to rethink current programs, to experiment. Our commitment to international science is a good example: we support many excellent scientists around the world, but can we do it better? For example, should our international efforts track the “people not projects” philosophy that guides our U.S.-based program? Our domestic and international science programs will come under the same administrative leadership as we consider these important questions over the coming months.

Like Tom, who kept a laboratory at the University of Colorado at Boulder throughout his presidency, I plan to remain an active scientist. Weekends will find me at the Janelia Farm Research Campus, where three colleagues and I are working on new imaging technologies that will capture the activity of single molecules. Although I have scaled back the scope of my laboratory at the University of California, Berkeley, it's where you'll find me during many vacations and holidays. I may be something of a workaholic, but this isn't work for me. It's fun—equal to the joys of fishing.

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