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May '08
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Small Molecules for Big Medicinessmall arrow

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Making Math Relevantsmall arrow

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PERSPECTIVES & OPINIONS
Stuart L. Schreiber divider

Small Molecules for Big Medicines


Drug discovery is an expensive process that can take dozens of years and result in only a few compounds making it to market. Moresmall arrow

Claudia M. Neuhauser divider

Making Math Relevant


Do biologists need to know how to build corrugated metal roofs? Moresmall arrow

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Opinions
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Perspectives Callout

Edited by Sarah C.P. Williams

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Linda C. Hsieh-Wilson
HHMI INVESTIGATOR
California Institute of Technology

“Chemistry is all around us—it's the reason we exist. From the enzymes that break down our food to blood clotting and skin healing after we scrape our elbow, everything is chemical and biochemical reactions—molecules dancing with one another that give rise to everything we are and do.” bullet


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Jennifer a. Doudna
HHMI INVESTIGATOR
University of California, Berkeley

“Two specific ways that chemistry affects (improves!) the average person's life come to mind: one is the Haber-Bosch method of ammonia production, developed in the early 20th century. It enables the abundant nitrogen gas in the atmosphere to be converted to ammonia, which can then be turned into nitrates and nitrites for fertilizer. The process has revolutionized modern agriculture. The second is the production of antibiotics, which came about initially through careful isolation and analysis of natural compounds. The challenge to scientists and to society is to use such advances wisely.” bullet


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Milan Mrksich
HHMI INVESTIGATOR
University of Chicago

“Chemistry touches on every aspect of our lives. We live in a material world, and molecules are the stuff of materials. Over the next 20 years, the need to develop new sources of energy and to manage the impact of energy use on the environment will drive profound developments in catalysis—the process of making reactions more efficient. Chemists will pave the way toward lowering the energy it takes to produce materials and enabling recycling of unwanted
by-products.” bullet


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David R. Liu
HHMI INVESTIGATOR
Harvard University

“Chemistry is a body of knowledge, a set of tools, and a philosophy. The knowledge and the tools have enabled life-saving drugs, computers, higher crop yields, ways to harvest and store energy, and all the non-natural substances used by society including steel, paint, suntan lotion, and modern anesthesia. The philosophy embraces manipulating the structure of molecules to change their properties. It encourages us to improve upon nature's substances and dares us to design and make our own molecules that might fight a disease, make a better battery, or shed light on life's origins.” bullet


Photos: Hsieh-Wilson: John Hayes / AP, ©HHMI; Doudna: Michael Marsland; Mrksich: Aynsley Floyd / AP ©HHMI; Liu: Robert Klein / AP ©HHMI
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