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It's an insidious, silent killer that can surface suddenly to trigger heart attack, kidney failure or stroke. With every heartbeat, chronic high blood pressure overworks the heart and distends arteries, slowly causing them to thicken and clog. But exactly how and why the disease arises has been a subject of confusion.
Before Rick Lifton and his colleagues began studying hypertension at the molecular level, most doctors viewed it as an impossibly intricate puzzle whose pieces consisted largely of environmental influences such as diet and exercise.
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