HHMI Investigators Eric Gouaux and Michael Rosen are using AI to transform cryo-electron tomography into a molecular detective.
This story is part of a series exploring AI@HHMI projects.By studying mouse lemur families, HHMI Investigator Mark Krasnow uncovered an important role for magnesium in human heart health and disease. A team led by HHMI Hanna Gray Fellow Shan Meltzer has created a detailed, cell-by-cell map of the spinal cord that offers a new framework for understanding chronic pain and provides a powerful new resource for the field.By probing the cellular and molecular processes that drive sleep, HHMI Investigator Amita Sehgal and her team are uncovering how snoozing helps ensure there’s a source of clean energy to power brain cells.Over a 50-year career, former HHMI scientist and leader David Clapham reshaped our understanding of ion channels by relentlessly pursuing experimental evidence across scientific disciplines.HHMI Investigator Karolin Luger is being honored by the Vilcek Foundation for her research into nucleosomes — the DNA-packaging structures inside cells — that has led to the development of innovative drugs for treating diseases, including cancer.By studying zebra finches as they sing, Freeman Hrabowski Scholar Vikram Gadagkar is uncovering how the brain learns, evaluates mistakes, and performs under pressure.HHMI Janelia Research Campus Group Leaders Alison Tebo and Srinivas Turaga are creating new AI models to optimize the development of sensors used to track biological processes happening inside cells in real time – key tools used to understand how the body and brain work.
This multi-part series dives into the ambitious AI-driven biomedical research projects happening across HHMI labs, including efforts to transform biological imaging, supercharge brain mapping and revolutionize molecular structure prediction. HHMI Investigator Kevan Shokat and his lab are charting new therapies to outmaneuver drug resistance and better target common cancer cell mutations.