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  By Brian Vastag

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Tom Steitz likes to tell a story about the day that 
launched him toward a Nobel Prize. It was spring 1963, and he was a graduate student at Harvard University. A buzz ran through the medical campus: Austrian-born chemist Max Perutz of the Cambridge Laboratory of Molecular Biology was lecturing about how he and John Kendrew had unraveled the shapes of the oxygen-toting blood protein hemoglobin and the muscle protein myoglobin. The two were the first to reveal the atomic structure of a protein, and they did it with the powerful yet fussy technique of x-ray crystallography. The work earned them the 1962 Nobel Prize in Chemistry.

In front of a capacity crowd, Perutz turned on a stereoscopic projector and told the audience to don their 3-D glasses. An assistant twiddled some projector knobs. “Out popped this gargantuan molecule over Max's head,” Steitz recalls. “And the whole audience went, ‘Whoa!’ Everybody was stunned. None of us had seen the atomic structure of a protein—ever.”

Photo: Paul Fetters

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