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FEATURES
Ahead of the Curve

  By Dan Ferber

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It was not the first time Jack Szostak gambled on an experiment, nor 
would it be the last. Risky, big-payoff experiments like these kept science exciting. Sure, bread-and-butter studies that would inform no matter how 
they turned out were always going to be necessary, he knew. But 
it was experiments like these that Szostak liked best—far-fetched, 
perhaps, but potentially groundbreaking.

What if he took chromosome tips from a single-celled pond creature called Tetrahymena and transplanted them into baker's yeast, an organism evolutionarily miles away. In Tetrahymena, those tips, called telomeres, functioned like the tips of shoelaces, protecting the DNA in chromosomes from damage. Would they protect yeast DNA in the same way?

Photo: Leah Fasten

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