HHMI Bulletin February 2008


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Guided By His Inner Compass






	A mother and child flee postwar Italy, arriving in Pennsylvania to a home steeped in science where the child finds stability and inspiration.






	Scientists whose work challenges conventional wisdom often toil for years before their ideas catch on—if ever.

	It pays to know a good risk and bet on it.

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	Cold Nights and Hot Chocolate In the chilliest months of the year, Ralph Isberg's backyard is a lively neighborhood hot spot. More		An Absorbing Mascot For one biologist team, SpongeBob SquarePants is more than just a cartoon character for kids. More		Bright Ideas From Down Below A trip to the local pet store was just what Sergey Lukyanov needed to kick start the development of a new fluorescent protein. More






	From Sperm to Stem Cells Adult stem cells derived from mouse testes appear to match the capabilities of embryonic stem cells. More		Fighting Malaria on His Home Turf With a mix of lab studies and field trials, this scientist and his research partner are stopping the malaria parasite from disarming the immune system. More		AIDS: No Time for Complacency Teenagers learn that HIV infection is still a virtual death sentence in most of the world, and that it is up to their generation to help keep up the fight. More





	Bedside Inspiration A new group of HHMI investigators tackles basic research questions by splitting time between the laboratory and the clinic. More HHMI Launches Public-Access Publishing Policy Research articles to be published only in accessible journals. More		Barshefsky Elected to HHMI Board of Trustees Ambassador Charlene Barshefsky brings an impressive assortment of experiences to HHMI. More		Bringing Down Cancer's House of Cards Defining an elaborate yet fragile control pathway offers a new strategy for toppling many cancers. More

	Legions of Hijackers The multi-layered success strategy behind this ingenious pathogen is beginning to unfold. More		Tick-Tock Goes a Bacterial Clock Researchers now better understand the "gears" on this unusual circadian clock. More		From Marshmallows to Missiles Knockout yields clues to how sperm are perfected for penetration. More

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