What Robert F. Siliciano saw when he entered his lab five years ago triggered conflicting emotions. He was elated because the clear substrate in the plates had turned blue, confirming his hypothesis. But he also felt a deep sadness because it meant bad news for those AIDS patients who had been enjoying remarkable clinical benefits from new protease inhibitor drugs. continued...

Illustration: George Eade, illustrator, George Eade, Inc.

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Reprinted from the HHMI Bulletin,
December 2002, pages 12-17.
©2002 Howard Hughes Medical Institute