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Neuroscience

From the 2008 Holiday Lectures—Making Your Mind: Molecules, Motion, and Memory

Clive Wearing: A man without memory

Clive Wearing has lost his ability to remember and lives in a perpetual state of having just awoken.

1 minute 15 seconds


Demo: Phrenology

Dr. Kandel illustrates the practice of the now-debunked theory of phrenology.

1 minute 4 seconds


A patient with conduction aphasia

A patient can both comprehend and articulate language, but cannot verbalize what is a clear idea in her mind.

1 minute 9 seconds


Clive Wearing plays piano despite memory deficit

Even though Clive Wearing cannot remember people or events, his piano-playing skills are intact.

1 minute 6 seconds


Demo: SHH concentration and eye position

A reduction in the level of sonic hedgehog (SHH) gene expression can lead to cyclopia.

1 minute 22 seconds


Demo: The electrical activity of Dr. Jessell's arm

A live recording of muscle activity from Dr. Jessell's biceps and triceps muscles.

2 minutes 15 seconds


Growth cones in action

The growth cones of two neurons sense and interact with one another.

34 seconds


Long-distance neuronal path-finding

Retinal axons travel across the brain, reading navigation cues, to find appropriate targets.

31 seconds


Contact repulsion of a growth cone

A growth cone contacts a repellant molecule on another axon, collapses, and withdraws.

1 minute 5 seconds


Computer analysis of human movement

Dr. Jessell's leg muscle activation patterns are recorded during walking.

56 seconds


Demo: Testing a student's proprioceptive reflex

A knee-jerk reflex depends on a simple circuit of proprioceptive sensory neurons and spinal motor neurons.

1 minute 21 seconds


Demo: Proprioception makes raising a mug easy

The average person has no difficulty raising a coffee mug.

52 seconds


Without proprioception, raising a mug is difficult

A person with a disease that kills proprioceptive neurons has severe problems with the simplest of movements.

1 minute 36 seconds


Behavior of mice that lack proprioception

Genetically engineered mice lacking proprioceptive sensory axons are not capable of well-coordinated walking.

25 seconds


Walking versus hopping

In a giraffe's walk, left and right limbs move alternately, while in a kangaroo's hop, opposing limbs move together.

1 minute 12 seconds


Dr. Jessell's muscle activity when he hops or walks

Electrical activity recorded from the leg muscles reveals different patterns of activation during different gaits.

45 seconds


Mutant mice with crossed excitation hop

Kangaroo-like hopping when spinal cord excitatory interneurons cross the midline to stimulate both sides.

1 minute 18 seconds


Ian Waterman: Compensating for proprioceptive loss

In the absence of proprioceptive feedback, some individuals can compensate by using visual feedback.

1 minute 41 seconds


Demo: Touching thumb to fingers with proprioception

Proprioceptive feedback makes it easy to touch one's thumb to one's fingers without looking.

57 seconds


Waterman touching thumb to fingers without feedback

In the absence of proprioception and visual feedback, it is impossible to touch thumb to fingers accurately.

1 minute 15 seconds


Demo: Using spatial memory to clear an obstacle

Even without visual feedback, we are able to negotiate an obstacle using spatial memory.

2 minutes 9 seconds


Cat remembers obstacle location for many minutes

Even when distracted by food, the cat's brain encodes and retains the location of an obstacle.

1 minute 39 seconds


Demo: Meet a live Aplysia californica

Aplysia californica is a marine snail with a simple nervous system suitable for research on learning and memory.

1 minute 40 seconds


Aplysia's gill-withdrawal reflex and sensitization

A touch to the Aplysia's siphon causes a gill withdrawal, a simple reflex for studying memory.

1 minute 25 seconds


Mice navigate a Barnes maze to test spatial learning

Mice can be trained to use spatial cues to navigate a maze that tests their ability to remember specific locations.

2 minutes 14 seconds


Visualizing learning

Dr. Harshad Vishwasrao guides you through a collection of images showing neuronal growth and synaptic formation representative of anatomical changes that occur during learning.

5 minutes 39 seconds


Interview with Dr. Thomas Jessell

An interview with Dr. Jessell.

6 minutes 12 seconds


Interview with Dr. Eric Kandel

An interview with Dr. Kandel.

6 minutes 20 seconds


Interview with Dr. Adam Hantman

An interview with Dr. Adam Hantman, a post-doctoral student in Thomas Jessell's lab.

3 minutes 25 seconds


Interview with Tessa Hirschfeld-Stoler

An interview with Tessa Hirschfeld-Stoler, a lab technician in Eric Kandel's lab.

3 minutes 23 seconds


Interview with Priya Rajasethupathy

An interview with Priya Rajasethupathy, an M.D./Ph.D. student in Eric Kandel's lab.

3 minutes 44 seconds


Interview with Dr. Laskaro Zagoraiou

An interview with Dr. Laskaro Zagoraiou, a post-doctoral student in Thomas Jessell's lab.

3 minutes 31 seconds


From the 2003 Holiday Lectures—Learning From Patients: The Science of Medicine

Learning from Mice: The Science of Transgenic Technology

What do humans, flies, and worms have in common? More than you might think. See how transgenic organisms are engineered, and how they enable researchers to study genetic diseases.

11 minutes 7 seconds


Spinocerebellar Ataxia Case Study

Dr. Huda Zoghbi interviews Milan Cloud, a patient who has inherited the neurological disorder spinocerebellar ataxia 1, or SCA1.

3 minutes 29 seconds


Rett Syndrome

Dr. Zoghbi introduces the topic of Rett syndrome by showing how development usually progresses in a young girl. She then shows an excerpt from Silent Angels, introduced by Julia Roberts, which shows how Rett syndrome affects development.

2 minutes 51 seconds


Rett Syndrome Mouse

Dr. Zoghbi shows how a mouse that has been given the gene responsible for Rett syndrome exhibits some of the same neurological symptoms as human Rett patients.

1 minute 13 seconds


SCA1 Mouse on Rotarod

Dr. Zoghbi demonstrates how mice that have been given the gene responsible for spinocerebellar ataxia 1 (SCA1) are tested on a device called a rotarod to quantify the amount of ataxia present.

34 seconds


Interview with Dr. Huda Zoghbi

An interview with Dr. Zoghbi.

5 minutes 51 seconds


Interview with Jennifer Gatchel

An interview with Jennifer Gatchel, a scientist in Dr. Zoghbi's lab.

4 minutes 50 seconds

 

Infectious Disease

From the 2007 Holiday Lectures: AIDS: Evolution of an Epidemic

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Adherence and resistance

Adam Barrett, a nurse who is HIV positive, discusses his first symptoms and the challenges of adhering to a drug regimen.

7 minutes 41 seconds


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Adhering to an antiretroviral regimen

Adam Barrett describes his seven-drug antiretroviral regimen and the importance of adherence.

1 minute 9 seconds


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Benefits of an antiretroviral regimen

Zinhle Thabethe describes how antiretroviral therapy has changed her life.

1 minute 50 seconds


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CTL killing a target cell

Video microscopy of a cytotoxic T lymphocyte in action.

1 minute 16 seconds


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Demo: Rapid AIDS virus test

A live demonstration of how a rapid antibody-based HIV test works.

7 minutes 40 seconds


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Demo: Student adherence activity

Using tic tac mints as anti-HIV drug stand-ins, students experience the challenges of adhering to an antiretroviral regimen.

4 minutes 18 seconds


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First AIDS patients

Dr. Michael Gottlieb was the first physician to notice the new disease of AIDS.

5 minutes 40 seconds


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HIV's origins in Africa

Dr. Beatrice Hahn discusses how HIV originated in Africa by cross-species transmission from chimpanzees to humans.

1 minute 12 seconds


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Living with HIV

Catherine Gaynes, an HIV-positive patients, discusses her HIV diagnosis, how her family reacted, and avoiding HIV infection.

4 minutes 46 seconds


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Origin of HIV

Dr. Beatrice Hahn's research has traced the origin of HIV to chimpanzees in Cameroon.

5 minutes 31 seconds


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South Africa: The "gogo" (grandmother)

When parents die of AIDS, the orphans often go to live with a "gogo," the Zulu word for grandmother.

2 minutes 7 seconds


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South Africa: St. Mary's Hospital

How a South African hospital is coping with the HIV/AIDS epidemic and its many related healthcare issues.

4 minutes 11 seconds


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South Africa: Traditional healers

Doctors hope to encourage healers to direct their patients to clinics for TB and AIDS-related diseases.

2 minutes 19 seconds


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South Africa: Tuberculosis

A glimpse of the TB ward at a South African hospital, illustrating an illness associated with the AIDS epidemic.

3 minutes 8 seconds


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South Africa: Umndeni "Family" Care Program

A program designed to provide health care and housing to South Africans living in poverty.

3 minutes 51 seconds


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South Africa: WhizzKids

Using soccer to teach children how to make important life choices and how to avoid HIV infection.

3 minutes 5 seconds


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Symptoms of acute HIV infection

Adam Barrett remembers his symptoms of acute HIV infection.

57 seconds


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Interview with Bisola Ojikutu

An interview with Dr. Ojikutu.

5 minutes


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Interview with Bruce Walker

An interview with Dr. Walker.

4 minutes 56 seconds


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Interview with Kwame Atsina

An interview with Kwame Atsina, an undergraduate who discusses what it's like to be in a lab doing scientific research.

4 minutes 3 seconds


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Interview with Silvia Caballero

An interview with Silvia Caballero, an undergraduate who discusses what it's like to be in a lab doing scientific research.

4 minutes 8 seconds


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Interview with Tobi Ogbechie

An interview with Tobi Ogbechie, an undergraduate who discusses what it's like to be in a lab doing scientific research.

3 minutes 43 seconds


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Interview with Katie Walter

An interview with Katie Walter, an undergraduate who discusses what it's like to be in a lab doing scientific research.

3 minutes 27 seconds

 


From the 1999 Holiday Lectures: 2000 and Beyond: Confronting the Microbe Menace

Bacterial Growth

Dr. Brett Finlay shows how bacteria can grow rapidly to incredible numbers, and also explains what limits this explosive growth.

54 seconds


Cheek Cells and Bacteria

Dr. Brett Finlay enlists a student volunteer to show the surprisingly high amount of bacteria found in his own mouth.

1 minute 27 seconds


Listeria Infection Demonstration

Dr. Finlay and a student volunteer show how Listeria infects a cell, using a marble and some yellow gelatin.

1 minute 4 seconds


Listeria Video

This microscope video shows how live Listeria move via actin filaments in an infected cell.

1 minute 7 seconds


Penicillin acting on bacteria

Penicillin, as shown in this video, causes the cell walls of bacteria to rupture.

33 seconds


Salmonella Infection Demonstration

Dr. Finlay and another student volunteer illustrate how Salmonella infects a cell, using a marble, plastic wrap, and some yellow gelatin.

1 minute 20 seconds


Salmonella Video

Salmonella are a common bacteria associated with food poisoning. Dr. Finlay shows live Salmonella under the microscope to demonstrate how far and fast they can move.

37 seconds


Size Analogies of Bacteria and Viruses

Dr. Finlay and Dr. Richard Ganem use physical analogies to compare the size of bacteria and viruses relative to a standard mammalian cell.

1 minute 43 seconds


Transmission of Disease on an Airplane

Dr. Finlay, using his student audience, gives a live demonstration of how an antibiotic-resistant strain of tuberculosis managed to spread through the passengers on an airplane.

2 minutes 4 seconds


Virulence Injection Simulation

Using a bagel, a syringe, and blue dye to illustrate how some virulent strains of bacteria inject virulence factors into a cell.

2 minutes


Interview with Don Ganem

An interview with Dr. Ganem.

4 minutes 22 seconds


Interview with Brett Finlay

An interview with Dr. Finlay.

2 minutes 32 seconds

 

Stem Cells

From the 2006 Holiday Lectures — Potent Biology: Stem Cells, Cloning, and Regeneration

Planarian Regeneration and Stem Cells

A mini-documentary discussing the remarkable regenerative capabilities of the planarian, and how HHMI researcher Alejandro Sánchez Alvarado uses them to study the biology of stem cells.

11 minutes 46 seconds


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Cultured Human Embryonic Stem Cells

Cell cultures derived from human embryonic stem cells can reproduce indefinitely and also differentiate into specialized cell types, including beating heart cells.

1 minute 17 seconds


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Somatic Cell Nuclear Transfer Video

Somatic cell nuclear transfer (SCNT) is performed looking through a microscope and using small glass pipettes to handle human eggs and to remove and transfer nuclei from one cell to another. SCNT is used to produce clones of cells with the same genetic background as the donor nucleus.

1 minute 59 seconds


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DNA Gene Chip Explanation

Dr. Melton describes the process used to extract DNA from a cell and to analyze it on a gene chip.

51 seconds


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Antlers and Mammalian Regeneration

Dr. Rosenthal describes how antlers are one of the few examples of complete mammalian regeneration.

2 minutes 18 seconds


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Heart Attack and Blocked Arteries

Dr. Rosenthal uses a model of a heart and an artery to describe how blockages lead to heart attack and tissue damage.

51 seconds


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Interview with Douglas Melton

An interview with Dr. Melton.

5 minutes 6 seconds


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Interview with Nadia Rosenthal

An interview with Dr. Rosenthal.

4 minutes 55 seconds


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Interview with Amy Greenwood and Alice Chen

An interview with Amy Greenwood and Alice Chen, two scientists in Dr. Melton's lab.

6 minutes 58 seconds


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Interview with Olivier Mirabeau

An interview with Olivier Mirabeau, a scientist in Dr. Rosenthal's lab.

5 minutes 4 seconds


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Interview with Mumna Al Banchaabouchi

An interview with Dr Mumna Al Banchaabouchi, researcher in the Mouse Phenotyping Core at EMBL in Monterotondo Italy.

2 minutes 55 seconds


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Interview with Jose Gonzales

An interview with Dr. Jose Gonzales, Manager of the Laboratory Animal Resources and Knockout Mouse Facility at EMBL in Monterotondo Italy.

4 minutes 11 seconds

 

Evolution

From the 2005 Holiday Lectures — Evolution: Constant Change and Common Threads

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Stickleback Fossil Primer

A brief introduction to how stickleback fossils are collected and used to study evolution. It also shows the students who attended the 2005 Holiday Lectures taking part in a fossil-collecting activity.

9 minutes


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Breeding Corn from Teosinte

Corn was originally bred from the teosinte plant by native Mexican farmers. The morphologies of modern-day corn and teosinte plants are compared to illustrate how artificial selection can bring about dramatic changes in plants.

52 seconds


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Dog Breeding

The many forms of dogs that exist today were all created through selective breeding from the dog's ancestor, the wolf. In a span of less than 10,000 years, breeders have changed traits and body shapes of dogs by artificial selection-for example, emphasizing different aspects of hunting and herding behavior.

1 minute 52 seconds


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Fruit Fly Courtship

Male courtship dances in two fruit fly species show that the wing spots play a prominent role.

55 seconds


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Galapagos Creatures

These are some of the animal species Charles Darwin would have seen when he visited the Galapagos Islands.

24 seconds


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Stickleback Environment

At the end of the ice age, the retreating ice sheet created many new lakes, some of which were colonized by sticklebacks. The presence of different predators in different lakes dictated the subsequent evolution of each isolated lake stickleback over the course of about 10,000 years. Some groups kept their spines to use against predatory fish, such as trout. Others lost their spines, perhaps to evade aquatic insect predators.

1 minute 26 seconds


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Fossil Record of Stickleback Evolution

A quarry site in Nevada carries the evolutionary history of a population of stickleback fish that resided there when it was a freshwater lake. In a short time span in evolutionary terms—about 10,000 years—the fish population can be seen to dramatically reduce the size of their pelvic spines. This particular fossil record is remarkably complete with nearly year-by-year detail which includes documentation of intermediate forms.

1 minute 26 seconds


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Stickleback Fish on Jeopardy!

The identity of the stickleback fish stumps the contestants on the game show.

2 minutes 2 seconds


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Interview with Sean Carroll

An interview with Dr. Carroll.

4 minutes 55 seconds


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Interview with David Kingsley

An interview with Dr. Kingsley.

4 minutes 41 seconds


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Interview with Stephanie Nuñez

An interview with Stephanie Nuñez, an HHMI EXROP student in Dr. Kingsley's lab.

4 minutes 37 seconds


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Interview with Chris Hittinger

An interview with Chris Hittinger, a scientist in Dr. Carroll's lab.

4 minutes 45 seconds

 

Obesity

From the 2004 Holiday Lectures — Science of Fat

Marathon Mouse

Dr. Ronald Evans discusses the so-called "marathon" mouse, with a mutation in the PPAR-gamma gene, and its performance on a treadmill relative to a normal mouse.

52 seconds


Mouse Activity

Dr. Evans compares the activity of a normal mouse to one with a mutation in a key gene controlling obesity.

29 seconds


Pima Indians

A clip about the Pima Indian tribe and how environment has affected them.

2 minutes 35 seconds


Interview with Dr. Ronald Evans

An interview with Dr. Evans.

5 minute 19 seconds


Interview with Dr. Jeffrey Friedman

An interview with Dr. Friedman.

5 minute 32 seconds


Interview with Grant Barish

An interview with Grant Barish, a scientist in Dr. Evans's lab.

5 minutes 50 seconds


Interview with Shirly Pinto

An interview with Shirly Pinto, a scientist in Dr. Friedman's lab.

6 minutes 8 seconds

 

Cancer

From the 2003 Holiday Lectures — Learning From Patients: The Science of Medicine

Polyp Removal

Dr. Vogelstein shows video taken during a colonoscopy and the removal of a polyp.

36 seconds


Interview with Dr. Bert Vogelstein

An interview with Dr. Vogelstein.

5 minutes 51 seconds


Interview with Harith Rajagopalan

An interview with Harith Rajagopalan, a scientist in Dr. Vogelstein's lab.

4 minutes 50 seconds

 

Genomics and Chemical Genetics

From the 2002 Holiday Lectures — Scanning Life's Matrix: Genes, Proteins, and Small Molecules

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Diversity-Oriented Synthesis

Diversity-oriented synthesis (DOS) is a strategy used by chemical biologists to create a huge diversity of small molecules with potentially useful properties. A scientist working in Dr. Stuart Schreiber's lab shows us how engineering, computer science, chemisty, and biology are all used in DOS.

5 minutes 41 seconds


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Gene Chip Manufacturing

Dr. Eric Lander describes the process used to manufacture gene chips. Gene chips, also called DNA microarrays, have a broad range of applications in current research, including enabling researchers to measure the activity of thousands of genes simultaneously.

1 minute 56 seconds


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Microarrayer In Action

How a microarraying robot delivers hundreds of small molecules to a series of slides.

1 minute 59 seconds


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Interview with Dr. Stuart Schreiber

An interview with Dr. Schreiber.

4 minutes 54 seconds


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Interview with Dr. Eric Lander

An interview with Dr. Lander.

5 minutes 30 seconds


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Interview with Angela Koehler

An interview with Angela Koehler, a scientist in Dr. Schreiber's lab.

4 minutes 40 seconds


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Interview with Manolis Kamvysselis

An interview with Manolis Kamvysselis, a scientist in Dr. Lander's lab.

4 minutes 29 seconds

 

Sex Determination

From the 2001 Holiday Lectures — The Meaning of Sex: Genes and Gender

Amoeboid Sperm of C. elegans

Video closeup of the C. elegans sperm that moves like an amoeba.

10 seconds


C. elegans Mating

Video microscopy of mating between a male and a hermaphrodite C. elegansroundworm.

56 seconds


Clonal vs Sexual Reproduction

What does a stack of fruits and vegetables have to do with the theoretical advantages of sexual reproduction? Find out in this demonstration with student audience members and Dr. David Page.

8 minutes 55 seconds


Dosage Compensation in C. elegans

A demonstration by Dr. Barbara Meyer of how a branched genetic pathway can be affected by mutations in different parts of the pathway.

8 minutes 55 seconds


Embryonic Cell Division in C. elegans

Time-lapse microscopy showing cell division from 1 to 2 to 4 cell stages in C. elegans with fluorescent chromosomes.

1 minute 30 seconds


From Fertilization to Egg Laying in C. elegans

Video of the fertilization of the C. elegans oocyte, the fusion of the egg and sperm nuclei, and the egg laying.

1 minute 12 seconds


Intracytoplasmic Sperm Injection (ICSI)

Video microscopy demonstrating how sperm from an infertile male can be injected into a female egg.

1 minute 15 seconds


Regulation of Sex Determination in C. elegans

A demonstration by Dr. Meyer showing how a balance of molecular elements trigger genetic pathways that determine the sex of a C. elegans worm.

6 minutes 3 seconds


Sperm Motility

Video microscopy of sperm motility in an average human male and an infertile male.

20 seconds


Interview with Dr. Barbara Meyer

A brief interview with Dr. Meyer.

5 minutes 17 seconds


Interview with Dr. David Page

A brief interview with Dr. Page.

6 minutes 31 seconds

 

Biological Clocks

From the 2000 Holiday Lectures — Clockwork Genes: Discoveries in Biological Time

Human Circadian Activity

This time-lapse videoclip shows human circadian activity while assembling a T. rex skeleton.

47 seconds


Mouse Circadian Activity

This time-lapse videoclip illustrates a mouse's nocturnal behavior.

41 seconds


Interview with Dr. Seymour Benzer

Are you a night owl or a morning lark? Noted researcher Dr. Seymour Benzer discusses how the difference between he and his wife sparked his interest in the topic of biological clocks.

57 seconds


Interview with Dr. Ron Konopka

Dr. Benzer is joined by Dr. Ron Konopka for a brief discussion of how the per gene is involved in mammalian clocks.

43 seconds


Interview with Dr. Michael Rosbash

A brief interview with Dr. Rosbash.

4 minutes 55 seconds


Interview with Dr. Joseph Takahashi

A brief interview with Dr. Takahashi.

6 minutes 11 seconds

 

Cardiovascular

From the 1998 Holiday Lectures — Of Hearts and Hypertension: Blazing Genetic Trails

Echocardiogram

Dr. Christine Seidman describes a live demonstration of an echocardiogram, with a description of the parts of the heart that are visualized.

4 min 44 sec


Kidney Function

Dr. Richard Lifton, along with student volunteers, uses an aquarium and salt to illustrate the amount of work the kidney performs each day to maintain proper levels of ions in the body.

4 min 29 sec

 

RNA

Enzymes That Are Not Proteins: The Discovery of Ribozymes

Listen to HHMI President Dr. Thomas Cech discussing his Nobel Prize–winning discovery of RNA's catalytic properties. Includes animations newly created for the discussion.

19 minutes


Which Balloon Has Hydrogen?

Air is an invisible gas as are hydrogen and helium. How can you tell if a balloon contains hydrogen? Hydrogen has particsular physical and chemical properties that can be tested. Dr. Cech enlists student volunteers to show how a chemical reaction can be used to identify a substance.

5 min 55 sec


Mr. Lincoln Glows

A catalyst is a substance that greatly accelerates a chemical reaction and yet does not directly participate in the reaction and is therefore not consumed. Dr. Cech uses a penny and a beaker of acetone to illustrate how a catalyst works.

5 min 40 sec


Oxalate Catalysis

Without an appropriate catalyst some chemical reactions would be so slow as to appear not to occur at all on the human timescale. However, when catalyzed, these reactions can be very dramatic. Dr. Cech shows a very colorful reaction involving oxalate catalysis.

5 min 54 sec


On Becoming a Scientist: Dr. Thomas Cech

HHMI President Dr. Thomas Cech discusses the path he took to become a scientist and his reaction to receiving the Nobel Prize.

9 min 15 sec

 

DNA

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Watson constructing base pair models

During the process of trying to elucidate the structure of DNA, Jim Watson made some cardboard models to try to understand how DNA nucleotides are paired. It helped him visualize how hydrogen atoms of paired nucleotides interact with each other to form a symmetrical structure that fits the double helix model

1 minute 42 seconds

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