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Video Clips Index
Evolution
From the 2011 Holiday Lectures — Bones, Stones, and Genes: The Origin of Modern Humans
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Dr. John Shea demonstrates the two main principles in the study of rock layers: superposition and association.
2 minutes 21 seconds |
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Stone tools similar to those found at prehistoric archaeological sties can be made by fracturing rocks, a technique known as flintknapping.
1 minute 23 seconds
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Prehistoric stone tools are classified into six broad technological modes by the level of sophistication and method of fabrication.
3 minutes 4 seconds
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Chimpanzees are capable of using rocks as tools to crack nuts for eating. But they don't appear to use sharp-edged tools.
29 seconds
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African rift valleys were formed by the separation of tectonic plates. Water flows down to the valley floors, creating rivers and lakes.
1 minute 1 second
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The floor of a rift valley is prone to periodic floods that carry in fine silt--the sedimentary matter responsible for fossil formation.
2 minutes 42 seconds
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Fossils are extremely fragile. Scientists remove them in a protective layer of plaster and clean sand away one grain at a time.
1 minute 27 seconds
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Fossilized dung beetle balls are part of a comprehensive fossil collection project to reconstruct the habitat of Ardipithecus ramidus.
39 seconds |
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Due to the delicate nature of fossils, a hardening chemical is dripped onto every fossil before it is removed from the soil.
19 seconds
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Dr. Shea discusses his early interest in anthropology, how field work has changed over the years, and his outside interests.
4 minutes 59 seconds |
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Dr. Tishkoff explains how studying genetic diversity can shed light on modern-day diseases, such as diabetes and obesity.
5 minutes 16 seconds |
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Dr. White talks about his passion both for his fieldwork and for educating the scientists of tomorrow.
4 minutes |
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Mr. Carlson outlines the path that he took to becoming a graduate student in the White lab, including his experience as a chef.
3 minutes 25 seconds
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Ms. Everhart recounts her fieldwork experiences as a member of the Shea lab and the results of her first flintknapping attempt.
4 minutes 10 seconds
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Ms. Gomez explains her research in the Tishkoff lab and how it may help in understanding malaria resistance.
4 minutes 18 seconds
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Ms. Pepe talks about her experiences doing field work with the Shea lab as an undergraduate at Stony Brook University.
3 minutes 36 seconds
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From the 2005 Holiday Lectures — Evolution: Constant Change and Common Threads
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Stickleback Fossil Primer
A brief introduction to how stickleback fossils are collected and used to study evolution. It also shows the students who attended the 2005 Holiday Lectures taking part in a fossil-collecting activity.
9 minutes
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Breeding Corn from Teosinte
Corn was originally bred from the teosinte plant by native Mexican farmers. The morphologies of modern-day corn and teosinte plants are compared to illustrate how artificial selection can bring about dramatic changes in plants.
52 seconds
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Dog Breeding
The many forms of dogs that exist today were all created through selective breeding from the dog's ancestor, the wolf. In a span of less than 10,000 years, breeders have changed traits and body shapes of dogs by artificial selection-for example, emphasizing different aspects of hunting and herding behavior.
1 minute 52 seconds
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Fruit Fly Courtship
Male courtship dances in two fruit fly species show that the wing spots play a prominent role.
55 seconds
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Galapagos Creatures
These are some of the animal species Charles Darwin would have seen when he visited the Galapagos Islands.
24 seconds
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Stickleback Environment
At the end of the ice age, the retreating ice sheet created many new lakes, some of which were colonized by sticklebacks. The presence of different predators in different lakes dictated the subsequent evolution of each isolated lake stickleback over the course of about 10,000 years. Some groups kept their spines to use against predatory fish, such as trout. Others lost their spines, perhaps to evade aquatic insect predators.
1 minute 26 seconds
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Fossil Record of Stickleback Evolution
A quarry site in Nevada carries the evolutionary history of a population of stickleback fish that resided there when it was a freshwater lake. In a short time span in evolutionary terms—about 10,000 years—the fish population can be seen to dramatically reduce the size of their pelvic spines. This particular fossil record is remarkably complete with nearly year-by-year detail which includes documentation of intermediate forms.
1 minute 26 seconds
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Stickleback Fish on Jeopardy!
The identity of the stickleback fish stumps the contestants on the game show.
2 minutes 2 seconds
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Interview with Sean Carroll
An interview with Dr. Carroll.
4 minutes 55 seconds
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Interview with David Kingsley
An interview with Dr. Kingsley.
4 minutes 41 seconds
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Interview with Stephanie Nuñez
An interview with Stephanie Nuñez, an HHMI EXROP student in Dr. Kingsley's lab.
4 minutes 37 seconds
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Interview with Chris Hittinger
An interview with Chris Hittinger, a scientist in Dr. Carroll's lab.
4 minutes 45 seconds
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Infectious Disease
From the 2010 Holiday Lectures: Viral Outbreak: The Science of Emerging Disease |
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Managua: Rapid, Unplanned Urbanization
Poor management of drainage, drinking water, and wastewater, makes excellent mosquito habitat.
49 seconds |
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To prevent mosquitoes from spreading diseases, it's essential to understand their life cycle.
1 minute 16 seconds |
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The Nicaraguan grassroots program teaches mosquito control methods to curb dengue fever epidemics.
1 minute 5 seconds
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In the effort to eradicate dengue and mosquitoes, neighborhood leaders work with local conditions.
1 minute 1 second |
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Reggaeton, a popular Latin music form, rallies against dengue.
2 minutes 9 seconds |
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Many infectious diseases affect people in Nicaragua, and identifying the pathogens is surprisingly difficult.
57 seconds |
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Several members of a Nicaraguan research team describe the impact of technology transfer.
2 minutes 17 seconds |
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Through the efforts of the Sustainable Sciences Institute, Nicaragua’s research capacity and disease-monitoring tools have improved dramatically.
11 minutes 16 seconds |
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The fight against dengue fever, and the mosquitoes that carry the virus, is being carried out by "brigadistas" in Managua's neighborhoods. Spanish with English subtitles.
7 minutes 38 seconds |
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Peter Skewes-Cox, and Dr. Graham Ruby, both in the DeRisi lab, explain state-of-the-art DNA sequencing and bioinformatic technologies.
6 minutes 35 seconds |
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Charles Runckel, a graduate student in the DeRisi lab, uses the Virochip to examine the mystery of bee colony collapse disorder.
7 minutes 45 seconds |
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“The Assemblers” (Peter Skewes-Cox and Dr. Graham Ruby) sing about DNA and proteins.
5 minutes 54 seconds |
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An interview with Dr. DeRisi.
5 minutes 20 seconds
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An interview with Dr. Harris.
5 minutes 31 seconds |
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Katherine Sorber, a graduate student in the DeRisi lab, describes her research on malaria.
4 minutes 23 seconds
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Ben Vincent describes his summer work collecting mosquitoes for Dr. Marm Kilpatrick's research on the ecology and epidemiology of the West Nile virus.
4 minutes 17 seconds |
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Kate Williams, a graduate student in the Harris lab, describes her epidemiological research linking antibodies and severe dengue in Nicaragua.
4 minutes 25 seconds
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Nathan Yozwiak, a graduate student in the Harris/DeRisi labs, discusses working in Nicaragua to discover a new virus infecting children.
5 minutes 42 seconds
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From the 2007 Holiday Lectures: AIDS: Evolution of an Epidemic
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Adherence and resistance
Adam Barrett, a nurse who is HIV positive, discusses his first symptoms and the challenges of adhering to a drug regimen.
7 minutes 41 seconds
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Adhering to an antiretroviral regimen
Adam Barrett describes his seven-drug antiretroviral regimen and the importance of adherence.
1 minute 9 seconds
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Benefits of an antiretroviral regimen
Zinhle Thabethe describes how antiretroviral therapy has changed her life.
1 minute 50 seconds
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CTL killing a target cell
Video microscopy of a cytotoxic T lymphocyte in action.
1 minute 16 seconds
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Demo: Rapid AIDS virus test
A live demonstration of how a rapid antibody-based HIV test works.
7 minutes 40 seconds
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Demo: Student adherence activity
Using tic tac mints as anti-HIV drug stand-ins, students experience the challenges of adhering to an antiretroviral regimen.
4 minutes 18 seconds
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First AIDS patients
Dr. Michael Gottlieb was the first physician to notice the new disease of AIDS.
5 minutes 40 seconds
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HIV's origins in Africa
Dr. Beatrice Hahn discusses how HIV originated in Africa by cross-species transmission from chimpanzees to humans.
1 minute 12 seconds
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Living with HIV
Catherine Gaynes, an HIV-positive patients, discusses her HIV diagnosis, how her family reacted, and avoiding HIV infection.
4 minutes 46 seconds
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Origin of HIV
Dr. Beatrice Hahn's research has traced the origin of HIV to chimpanzees in Cameroon.
5 minutes 31 seconds
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South Africa: The "gogo" (grandmother)
When parents die of AIDS, the orphans often go to live with a "gogo," the Zulu word for grandmother.
2 minutes 7 seconds
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South Africa: St. Mary's Hospital
How a South African hospital is coping with the HIV/AIDS epidemic and its many related healthcare issues.
4 minutes 11 seconds
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South Africa: Traditional healers
Doctors hope to encourage healers to direct their patients to clinics for TB and AIDS-related diseases.
2 minutes 19 seconds
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South Africa: Tuberculosis
A glimpse of the TB ward at a South African hospital, illustrating an illness associated with the AIDS epidemic.
3 minutes 8 seconds
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South Africa: Umndeni "Family" Care Program
A program designed to provide health care and housing to South Africans living in poverty.
3 minutes 51 seconds
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South Africa: WhizzKids
Using soccer to teach children how to make important life choices and how to avoid HIV infection.
3 minutes 5 seconds
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Symptoms of acute HIV infection
Adam Barrett remembers his symptoms of acute HIV infection.
57 seconds
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Interview with Bisola Ojikutu
An interview with Dr. Ojikutu.
5 minutes
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Interview with Bruce Walker
An interview with Dr. Walker.
4 minutes 56 seconds
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Interview with Kwame Atsina
An interview with Kwame Atsina, an undergraduate who discusses what it's like to be in a lab doing scientific research.
4 minutes 3 seconds
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Interview with Silvia Caballero
An interview with Silvia Caballero, an undergraduate who discusses what it's like to be in a lab doing scientific research.
4 minutes 8 seconds
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Interview with Tobi Ogbechie
An interview with Tobi Ogbechie, an undergraduate who discusses what it's like to be in a lab doing scientific research.
3 minutes 43 seconds
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Interview with Katie Walter
An interview with Katie Walter, an undergraduate who discusses what it's like to be in a lab doing scientific research.
3 minutes 27 seconds
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From the 1999 Holiday Lectures: 2000 and Beyond: Confronting the Microbe Menace
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Bacterial Growth
Dr. Brett Finlay shows how bacteria can grow rapidly to incredible numbers, and also explains what limits this explosive growth.
54 seconds
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Cheek Cells and Bacteria
Dr. Brett Finlay enlists a student volunteer to show the surprisingly high amount of bacteria found in his own mouth.
1 minute 27 seconds
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Listeria Infection Demonstration
Dr. Finlay and a student volunteer show how Listeria infects a cell, using a marble and some yellow gelatin.
1 minute 4 seconds
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Listeria Video
This microscope video shows how live Listeria move via actin filaments in an infected cell.
1 minute 7 seconds
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Penicillin acting on bacteria
Penicillin, as shown in this video, causes the cell walls of bacteria to rupture.
33 seconds
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Salmonella Infection Demonstration
Dr. Finlay and another student volunteer illustrate how Salmonella infects a cell, using a marble, plastic wrap, and some yellow gelatin.
1 minute 20 seconds
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Salmonella Video
Salmonella are a common bacteria associated with food poisoning. Dr. Finlay shows live Salmonella under the microscope to demonstrate how far and fast they can move.
37 seconds
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Size Analogies of Bacteria and Viruses
Dr. Finlay and Dr. Richard Ganem use physical analogies to compare the size of bacteria and viruses relative to a standard mammalian cell.
1 minute 43 seconds
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Transmission of Disease on an Airplane
Dr. Finlay, using his student audience, gives a live demonstration of how an antibiotic-resistant strain of tuberculosis managed to spread through the passengers on an airplane.
2 minutes 4 seconds
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Virulence Injection Simulation
Using a bagel, a syringe, and blue dye to illustrate how some virulent strains of bacteria inject virulence factors into a cell.
2 minutes
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Interview with Don Ganem
An interview with Dr. Ganem.
4 minutes 22 seconds
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Interview with Brett Finlay
An interview with Dr. Finlay.
2 minutes 32 seconds
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Biodiversity
From the 2009 Holiday Lectures — Exploring Biodiversity: The Search for New Medicines |
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Demonstration: Live Cone Snail
Dr. Olivera demonstrates a live specimen of Conus striatus.
1 minute 3 seconds
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Conus catus strikes a fish
A fish-hunting cone snail strikes its prey with a venomous harpoon, causes paralysis, and eats it.
2 minutes 11 seconds
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Philippines Biodiversity
The Philippines archipelago is rich in marine biodiversity, including venomous octopus and venomous snails.
2 minutes 8 seconds
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Conus textile strikes a snail
A snail-hunting species of cone snail stings its prey repeatedly, inducing the prey to thrash about.
43 seconds
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Conus imperialis strikes a worm
A worm-hunting cone snail species feeds on fireworms, and is unaffected by the prey's sharp bristles.
31 seconds
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Demonstration: Conus geographus can kill you
Larger cone snails produce more venom and are more dangerous to human beings in an accidental stinging.
1 minute 35 seconds
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Bobtail squid swimming and burrowing
The bobtail squid swims during the night to hunt. During the day, it burrows to hide from predators.
1 minutes 3 seconds
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Demonstration: Glowing bacteria in a flask
Dr. Bassler demonstrates the bioluminescence of a culture of Vibrio harveyi.
52 seconds
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Conus striatus strikes a fish
A species of fish-hunting cone snail quickly immobilizes its prey and swallows it.
45 seconds
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A Taser causes rigid paralysis
A Taser hyperexcites the nervous system to cause a rigid immobilization of its target.
30 seconds
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Conus bullatus "lightning strike"
This species of cone snail immobilizes its prey in a split second with lightning-strike cabal toxins.
1 minutes 11 seconds
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Conus tulipa hunts fish by net
Unlike a hook-and-line type fish-hunter, a net-hunting cone snail lures its prey into its wide mouth.
1 minutes 7 seconds
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Deep nets to harvest Turrids
Fishermen harvest deep-sea species of venomous snails by retrieving a net that had been deployed months ago.
1 minutes 42 seconds
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Demonstration: Quorum sensing molecules
Quorum sensing signal molecules have parts that are common between species as well as species-specific parts.
49 seconds
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Screening chemical libraries with robotics
Robotic equipment makes it possible to screen massive chemical libraries in just a matter of days.
1 minute 25 seconds
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Surrounded by the Ocean: Philippine Maritime Culture, Biodiversity, and Research
A mini-documentary illustrating the importance of the ocean to the Filipino way of life, and how that close connection helps biodiversity research.
11 minutes 55 seconds
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Cone Snails: Versatile Hunters
Dr. Jason Biggs of the University of Guam Marine Laboratory discusses the anatomy of cone snails and introduces us to a variety of cone snail species with different tactics to hunt and capture their prey.
13 minutes 38 seconds
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Interview with Bonnie Bassler
An interview with Dr. Bassler.
5 minutes 21 seconds
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Interview with Toto Olivera
An interview with Dr. Olivera.
5 minutes 16 seconds
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Interview with Lee Swem
An interview with Dr. Lee Swem, a post-doctoral fellow in Bonnie Bassler's lab.
4 minutes 13 seconds
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Interview with Audra Pompeani
An interview with Dr. Audra Pompeani, a graduate student in Bonnie Bassler's lab.
4 minutes 34 seconds
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Interview with Michael McIntosh
An interview with Dr. Michael McIntosh, who discovered the drug Prialt while working as an undergraduate in Dr. Olivera's lab.
4 minutes 37 seconds
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Neuroscience
From the 2008 Holiday Lectures—Making Your Mind: Molecules, Motion, and Memory
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Clive Wearing: A man without memory
Clive Wearing has lost his ability to remember and lives in a perpetual state of having just awoken.
1 minute 15 seconds
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Demo: Phrenology
Dr. Kandel illustrates the practice of the now-debunked theory of phrenology.
1 minute 4 seconds
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A patient with conduction aphasia
A patient can both comprehend and articulate language, but cannot verbalize what is a clear idea in her mind.
1 minute 9 seconds
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Clive Wearing plays piano despite memory deficit
Even though Clive Wearing cannot remember people or events, his piano-playing skills are intact.
1 minute 6 seconds
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Demo: SHH concentration and eye position
A reduction in the level of sonic hedgehog (SHH) gene expression can lead to cyclopia.
1 minute 22 seconds
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Demo: The electrical activity of Dr. Jessell's arm
A live recording of muscle activity from Dr. Jessell's biceps and triceps muscles.
2 minutes 15 seconds
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Growth cones in action
The growth cones of two neurons sense and interact with one another.
34 seconds
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Long-distance neuronal path-finding
Retinal axons travel across the brain, reading navigation cues, to find appropriate targets.
31 seconds
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Contact repulsion of a growth cone
A growth cone contacts a repellant molecule on another axon, collapses, and withdraws.
1 minute 5 seconds
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Computer analysis of human movement
Dr. Jessell's leg muscle activation patterns are recorded during walking.
56 seconds
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Demo: Testing a student's proprioceptive reflex
A knee-jerk reflex depends on a simple circuit of proprioceptive sensory neurons and spinal motor neurons.
1 minute 21 seconds
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Demo: Proprioception makes raising a mug easy
The average person has no difficulty raising a coffee mug.
52 seconds
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Without proprioception, raising a mug is difficult
A person with a disease that kills proprioceptive neurons has severe problems with the simplest of movements.
1 minute 36 seconds
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Behavior of mice that lack proprioception
Genetically engineered mice lacking proprioceptive sensory axons are not capable of well-coordinated walking.
25 seconds
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Walking versus hopping
In a giraffe's walk, left and right limbs move alternately, while in a kangaroo's hop, opposing limbs move together.
1 minute 12 seconds
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Dr. Jessell's muscle activity when he hops or walks
Electrical activity recorded from the leg muscles reveals different patterns of activation during different gaits.
45 seconds
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Mutant mice with crossed excitation hop
Kangaroo-like hopping when spinal cord excitatory interneurons cross the midline to stimulate both sides.
1 minute 18 seconds
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Ian Waterman: Compensating for proprioceptive loss
In the absence of proprioceptive feedback, some individuals can compensate by using visual feedback.
1 minute 41 seconds
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Demo: Touching thumb to fingers with proprioception
Proprioceptive feedback makes it easy to touch one's thumb to one's fingers without looking.
57 seconds
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Waterman touching thumb to fingers without feedback
In the absence of proprioception and visual feedback, it is impossible to touch thumb to fingers accurately.
1 minute 15 seconds
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Demo: Using spatial memory to clear an obstacle
Even without visual feedback, we are able to negotiate an obstacle using spatial memory.
2 minutes 9 seconds
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Cat remembers obstacle location for many minutes
Even when distracted by food, the cat's brain encodes and retains the location of an obstacle.
1 minute 39 seconds
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Demo: Meet a live Aplysia californica
Aplysia californica is a marine snail with a simple nervous system suitable for research on learning and memory.
1 minute 40 seconds
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Aplysia's gill-withdrawal reflex and sensitization
A touch to the Aplysia's siphon causes a gill withdrawal, a simple reflex for studying memory.
1 minute 25 seconds
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Mice navigate a Barnes maze to test spatial learning
Mice can be trained to use spatial cues to navigate a maze that tests their ability to remember specific locations.
2 minutes 14 seconds
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Visualizing learning
Dr. Harshad Vishwasrao guides you through a collection of images showing neuronal growth and synaptic formation representative of anatomical changes that occur during learning.
5 minutes 39 seconds
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Interview with Dr. Thomas Jessell
An interview with Dr. Jessell.
6 minutes 12 seconds
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Interview with Dr. Eric Kandel
An interview with Dr. Kandel.
6 minutes 20 seconds
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Interview with Dr. Adam Hantman
An interview with Dr. Adam Hantman, a post-doctoral student in Thomas Jessell's lab.
3 minutes 25 seconds
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Interview with Tessa Hirschfeld-Stoler
An interview with Tessa Hirschfeld-Stoler, a lab technician in Eric Kandel's lab.
3 minutes 23 seconds
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Interview with Priya Rajasethupathy
An interview with Priya Rajasethupathy, an M.D./Ph.D. student in Eric Kandel's lab.
3 minutes 44 seconds
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Interview with Dr. Laskaro Zagoraiou
An interview with Dr. Laskaro Zagoraiou, a post-doctoral student in Thomas Jessell's lab.
3 minutes 31 seconds
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From the 2003 Holiday Lectures—Learning From Patients: The Science of Medicine
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Learning from Mice: The Science of Transgenic Technology
What do humans, flies, and worms have in common? More than you might think. See how transgenic organisms are engineered, and how they enable researchers to study genetic diseases.
11 minutes 7 seconds
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Spinocerebellar Ataxia Case Study
Dr. Huda Zoghbi interviews Milan Cloud, a patient who has inherited the neurological disorder spinocerebellar ataxia 1, or SCA1.
3 minutes 29 seconds
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Rett Syndrome
Dr. Zoghbi introduces the topic of Rett syndrome by showing how development usually progresses in a young girl. She then shows an excerpt from Silent Angels, introduced by Julia Roberts, which shows how Rett syndrome affects development.
2 minutes 51 seconds
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Rett Syndrome Mouse
Dr. Zoghbi shows how a mouse that has been given the gene responsible for Rett syndrome exhibits some of the same neurological symptoms as human Rett patients.
1 minute 13 seconds
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SCA1 Mouse on Rotarod
Dr. Zoghbi demonstrates how mice that have been given the gene responsible for spinocerebellar ataxia 1 (SCA1) are tested on a device called a rotarod to quantify the amount of ataxia present.
34 seconds
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Interview with Dr. Huda Zoghbi
An interview with Dr. Zoghbi.
5 minutes 51 seconds
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Interview with Jennifer Gatchel
An interview with Jennifer Gatchel, a scientist in Dr. Zoghbi's lab.
4 minutes 50 seconds
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Stem Cells
From the 2006 Holiday Lectures — Potent Biology: Stem Cells, Cloning, and Regeneration
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Planarian Regeneration and Stem Cells
A mini-documentary discussing the remarkable regenerative capabilities of the planarian, and how HHMI researcher Alejandro Sánchez Alvarado uses them to study the biology of stem cells.
11 minutes 46 seconds
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Cultured Human Embryonic Stem Cells
Cell cultures derived from human embryonic stem cells can reproduce indefinitely and also differentiate into specialized cell types, including beating heart cells.
1 minute 17 seconds
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Somatic Cell Nuclear Transfer Video
Somatic cell nuclear transfer (SCNT) is performed looking through a microscope and using small glass pipettes to handle human eggs and to remove and transfer nuclei from one cell to another. SCNT is used to produce clones of cells with the same genetic background as the donor nucleus.
1 minute 59 seconds
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DNA Gene Chip Explanation
Dr. Melton describes the process used to extract DNA from a cell and to analyze it on a gene chip.
51 seconds
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Antlers and Mammalian Regeneration
Dr. Rosenthal describes how antlers are one of the few examples of complete mammalian regeneration.
2 minutes 18 seconds
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Heart Attack and Blocked Arteries
Dr. Rosenthal uses a model of a heart and an artery to describe how blockages lead to heart attack and tissue damage.
51 seconds
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Interview with Douglas Melton
An interview with Dr. Melton.
5 minutes 6 seconds
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Interview with Nadia Rosenthal
An interview with Dr. Rosenthal.
4 minutes 55 seconds
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Interview with Amy Greenwood and Alice Chen
An interview with Amy Greenwood and Alice Chen, two scientists in Dr. Melton's lab.
6 minutes 58 seconds
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Interview with Olivier Mirabeau
An interview with Olivier Mirabeau, a scientist in Dr. Rosenthal's lab.
5 minutes 4 seconds
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Interview with Mumna Al Banchaabouchi
An interview with Dr Mumna Al Banchaabouchi, researcher in the Mouse Phenotyping Core at EMBL in Monterotondo Italy.
2 minutes 55 seconds
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Interview with Jose Gonzales
An interview with Dr. Jose Gonzales, Manager of the Laboratory Animal Resources and Knockout Mouse Facility at EMBL in Monterotondo Italy.
4 minutes 11 seconds
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Obesity
From the 2004 Holiday Lectures — Science of Fat
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Marathon Mouse
Dr. Ronald Evans discusses the so-called "marathon" mouse, with a mutation in the PPAR-gamma gene, and its performance on a treadmill relative to a normal mouse.
52 seconds
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Mouse Activity
Dr. Evans compares the activity of a normal mouse to one with a mutation in a key gene controlling obesity.
29 seconds
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Pima Indians
A clip about the Pima Indian tribe and how environment has affected them.
2 minutes 35 seconds
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Interview with Dr. Ronald Evans
An interview with Dr. Evans.
5 minute 19 seconds
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Interview with Dr. Jeffrey Friedman
An interview with Dr. Friedman.
5 minute 32 seconds
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Interview with Grant Barish
An interview with Grant Barish, a scientist in Dr. Evans's lab.
5 minutes 50 seconds
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Interview with Shirly Pinto
An interview with Shirly Pinto, a scientist in Dr. Friedman's lab.
6 minutes 8 seconds
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Cancer
From the 2003 Holiday Lectures — Learning From Patients: The Science of Medicine
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Polyp Removal
Dr. Vogelstein shows video taken during a colonoscopy and the removal of a polyp.
36 seconds
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Interview with Dr. Bert Vogelstein
An interview with Dr. Vogelstein.
5 minutes 51 seconds
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Interview with Harith Rajagopalan
An interview with Harith Rajagopalan, a scientist in Dr. Vogelstein's lab.
4 minutes 50 seconds
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Genomics and Chemical Genetics
From the 2002 Holiday Lectures — Scanning Life's Matrix: Genes, Proteins, and Small Molecules
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Diversity-Oriented Synthesis
Diversity-oriented synthesis (DOS) is a strategy used by chemical biologists to create a huge diversity of small molecules with potentially useful properties. A scientist working in Dr. Stuart Schreiber's lab shows us how engineering, computer science, chemisty, and biology are all used in DOS.
5 minutes 41 seconds
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Gene Chip Manufacturing
Dr. Eric Lander describes the process used to manufacture gene chips. Gene chips, also called DNA microarrays, have a broad range of applications in current research, including enabling researchers to measure the activity of thousands of genes simultaneously.
1 minute 56 seconds
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Microarrayer In Action
How a microarraying robot delivers hundreds of small molecules to a series of slides.
1 minute 59 seconds
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Interview with Dr. Stuart Schreiber
An interview with Dr. Schreiber.
4 minutes 54 seconds
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Interview with Dr. Eric Lander
An interview with Dr. Lander.
5 minutes 30 seconds
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Interview with Angela Koehler
An interview with Angela Koehler, a scientist in Dr. Schreiber's lab.
4 minutes 40 seconds
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Interview with Manolis Kamvysselis
An interview with Manolis Kamvysselis, a scientist in Dr. Lander's lab.
4 minutes 29 seconds
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Sex Determination
Biological Clocks
Cardiovascular
From the 1998 Holiday Lectures — Of Hearts and Hypertension: Blazing Genetic Trails
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Echocardiogram
Dr. Christine Seidman describes a live demonstration of an echocardiogram, with a description of the parts of the heart that are visualized.
4 min 44 sec
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Kidney Function
Dr. Richard Lifton, along with student volunteers, uses an aquarium and salt to illustrate the amount of work the kidney performs each day to maintain proper levels of ions in the body.
4 min 29 sec
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RNA
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Enzymes That Are Not Proteins: The Discovery of Ribozymes
Listen to HHMI President Dr. Thomas Cech discussing his Nobel Prize–winning discovery of RNA's catalytic properties. Includes animations newly created for the discussion.
19 minutes
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Which Balloon Has Hydrogen?
Air is an invisible gas as are hydrogen and helium. How can you tell if a balloon contains hydrogen? Hydrogen has particsular physical and chemical properties that can be tested. Dr. Cech enlists student volunteers to show how a chemical reaction can be used to identify a substance.
5 min 55 sec
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Mr. Lincoln Glows
A catalyst is a substance that greatly accelerates a chemical reaction and yet does not directly participate in the reaction and is therefore not consumed. Dr. Cech uses a penny and a beaker of acetone to illustrate how a catalyst works.
5 min 40 sec
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Oxalate Catalysis
Without an appropriate catalyst some chemical reactions would be so slow as to appear not to occur at all on the human timescale. However, when catalyzed, these reactions can be very dramatic. Dr. Cech shows a very colorful reaction involving oxalate catalysis.
5 min 54 sec
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On Becoming a Scientist: Dr. Thomas Cech
HHMI President Dr. Thomas Cech discusses the path he took to become a scientist and his reaction to receiving the Nobel Prize.
9 min 15 sec
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DNA
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Watson constructing base pair models
During the process of trying to elucidate the structure of DNA, Jim Watson made some cardboard models to try to understand how DNA nucleotides are paired. It helped him visualize how hydrogen atoms of paired nucleotides interact with each other to form a symmetrical structure that fits the double helix model
1 minute 42 seconds
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