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  • The Making of the Fittest: Got Lactase? The Co-evolution of Genes and Culture

    The Making of the Fittest: Got Lactase? The Co-evolution of Genes and Culture

    Short Film

    (14 min 52 sec) Follow human geneticist Spencer Wells, Director of the Genographic Project of the National Geographic Society, as he tracks down the genetic changes associated with the ability to digest lactose as adults. Also available in Spanish.

  • Film Guides: Evolving Switches, Evolving Bodies

    Film Guides: Evolving Switches, Evolving Bodies

    Film Guide

    These classroom-ready resources complement the short film Evolving Switches, Evolving Bodies, which tells the story of the dramatic transformation of stickleback fish as they adapted to living in freshwater habitats drastically different from the ocean.

  • The Making of the Fittest: Evolving Switches, Evolving Bodies

    The Making of the Fittest: Evolving Switches, Evolving Bodies

    Short Film

    (15 min 27 sec) After the end of the last ice age 10,000 years ago, populations of marine stickleback fish became stranded in freshwater lakes dotted throughout the Northern Hemisphere in places like Alaska and British Columbia. These fish have adapted to a freshwater environment drastically different than the ocean.

  • Regulation of the Lactase Gene

    Regulation of the Lactase Gene

    Click & Learn

    Lactase persistence results from a mutation that changes how transcription factors interact, thereby affecting gene expression.

  • The Molecular Evolution of Gene Birth and Death

    The Molecular Evolution of Gene Birth and Death

    Activity

    An advanced lesson that describes the role of mutations in the birth and death of genes. It includes background information, examples, video clips, and animations.

  • Molecular Genetics of Color Mutations in Rock Pocket Mice

    Molecular Genetics of Color Mutations in Rock Pocket Mice

    Activity

    A lesson that requires students to transcribe and translate portions of the wild-type and mutant rock pocket mouse Mc1r genes and compare sequences to identify the locations and types of mutations responsible for the coat color variation described in the film. Also available in Spanish.

  • The Central Dogma Song

    The Central Dogma Song

    Clip

    (5 min 55 sec) “The Assemblers” (Peter Skewes-Cox and Dr. Graham Ruby) sing about DNA and proteins.

  • Dengue Virus Life Cycle

    Dengue Virus Life Cycle

    Animation

    (4 min 12 sec) Dengue virus has sophisticated mechanisms for entering a cell, for replicating its RNA genome, and for translating proteins.

  • HIV life cycle

    HIV life cycle

    Animation

    (4 min 52 sec) How HIV infects a cell and replicates itself using reverse transcriptase and the host's cellular machinery.

  • Protease inhibitors

    Protease inhibitors

    Animation

    (1 min 6 sec) Protease inhibitors prevent maturation of viral proteins inside HIV particles.

  • Understanding Embryonic Stem Cells

    Understanding Embryonic Stem Cells

    Lecture

    (58 min 27 sec) An overview of embryonic development, the progressive differentiation of cells, and properties of embryonic stem cells.

  • Visualizing Gene-Expression Patterns

    Visualizing Gene-Expression Patterns

    Click & Learn

    Learn about the different ways scientists are able to detect when genes are being expressed in various tissues.

  • Translation (basic detail)

    Translation (basic detail)

    Animation

    (2 min 6 sec) The ribosome is a molecular factory that translates the genetic information in RNA into a string of amino acids that becomes a protein. Inside the ribosome, the genetic code of the RNA is read three letters at a time and compared with the corresponding code on a transfer molecule. When a match occurs between the codes, the amino acid carried by the transfer molecule is added to the growing protein chain. Also available in Spanish.

  • Sex and Death: Too Much of a Good Thing

    Sex and Death: Too Much of a Good Thing

    Lecture

    (59 min 6 sec) Having too many chromosomes can lead to too much gene expression. Dr. Meyer explains how the gene that controls dosage compensation in C. elegans works.

  • Hermaphrodites: The Safer Sex

    Hermaphrodites: The Safer Sex

    Lecture

    (56 min 32 sec) Dr. Barbara Meyer explains the value of studying model organisms and introduces the nematode C. elegans.

  • The Mammalian Timekeeper

    The Mammalian Timekeeper

    Lecture

    (57 min 50 sec) Dr. Takahashi describes the powerful strategies that he and others have harnessed for understanding biological clocks in mammals.

  • PERfect TIMing

    PERfect TIMing

    Lecture

    (57 min 32 sec) Dr. Rosbash discloses how scientists have persuaded Mother Nature to reveal the inner workings of the fruit fly's biological clock.

  • Unwinding Clock Genetics

    Unwinding Clock Genetics

    Lecture

    (56 min 42 sec) Although tiny in size, the fruit fly has had a major impact on our understanding of circadian rhythms.

  • Clockwork Genes: Discoveries in Biological Time

    Clockwork Genes: Discoveries in Biological Time

    Lecture

    Four lectures highlight the research of two scientists who have made groundbreaking discoveries elucidating the molecular basis of circadian clocks—the internal timekeepers that govern fluctuations in behavior and physiology on a 24-hour cycle.

  • How Immune Cells Create Trillions of Receptors from a Few Hundred Parts

    How Immune Cells Create Trillions of Receptors from a Few Hundred Parts

    Lecture

    (59 min 48 sec) The human body has at least a trillion ways of recognizing that something foreign has invaded.

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