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Showing 61-80 of 89 Resources
  • Fruit Fly Courtship

    Fruit Fly Courtship


    (55 sec) Male courtship dances in two fruit fly species show that the wing spots play a prominent role.

  • Understanding Fat: Syndrome X and Beyond

    Understanding Fat: Syndrome X and Beyond


    (58 min 29 sec) Dr. Evans describes how fat communicates with muscle and how diet and exercise influence that relationship.

  • Deconstructing Obesity

    Deconstructing Obesity


    (58 min 20 sec) Dr. Friedman introduces the genes and circuits that control appetite, including the key role of leptin.

  • The Science of Fat

    The Science of Fat


    In the 2004 Holiday Lectures on Science, HHMI investigators Ronald M. Evans and Jeffrey M. Friedman discuss how the body regulates weight by carefully controlling the storage and burning of fat—and how a better understanding of these complex metabolic systems could lead researchers to treatments that curb obesity and improve public health. Awards 2006 Telly Awards; Silver

  • Marathon Mouse

    Marathon Mouse


    (53 sec) Dr. Ronald Evans discusses the so-called "marathon" mouse, with a mutation in the PPAR-gamma gene, and its performance on a treadmill relative to a normal mouse.

  • Mouse Activity

    Mouse Activity


    (30 sec) Dr. Evans compares the activity of a normal mouse to one with a mutation in a key gene controlling obesity.

  • Leptin Feedback Control System

    Leptin Feedback Control System


    (1 min 1 sec) Demonstrates how changes in the amount of fat tissue lead to changes in leptin levels and thus changes in appetite.

  • SCA1 Mouse on Rotarod

    SCA1 Mouse on Rotarod


    (35 sec) Dr. Zoghbi demonstrates how mice that have been given the gene responsible for spinocerebellar ataxia 1 (SCA1) are tested on a device called a rotarod to quantify the amount of ataxia present.

  • Rett Syndrome

    Rett Syndrome


    (2 min 52 sec) Dr. Zoghbi introduces the topic of Rett syndrome by showing how development usually progresses in a young girl. She then shows an excerpt from Silent Angels, introduced by Julia Roberts, which shows how Rett syndrome affects development.

  • Rett Syndrome Mouse

    Rett Syndrome Mouse


    (1 min 14 sec) Dr. Zoghbi shows how a mouse that has been given the gene responsible for Rett syndrome exhibits some of the same neurological symptoms as human Rett patients.

  • C. elegans Mating

    C. elegans Mating


    (57 sec) Video microscopy of mating between a male and a hermaphrodite C. elegans roundworm.

  • From Fertilization to Egg Laying in C. elegans

    From Fertilization to Egg Laying in C. elegans


    (1 min 12 sec) Video of the fertilization of the C. elegans oocyte, the fusion of the egg and sperm nuclei, and the egg laying.

  • Teacher Guide: Holiday Lectures on Science - 2000

    Teacher Guide: Holiday Lectures on Science - 2000

    Teacher Guide

    A guide written for teachers to accompany the 2000 Holiday Lectures on Science.

  • Are You a Morning or an Evening Person?

    Are You a Morning or an Evening Person?

    Click & Learn

    This survey, developed by Horne and Ostberg, will let you determine if you are a morning or an evening person.

  • Transgenic Fly Virtual Lab

    Transgenic Fly Virtual Lab

    Virtual Lab

    The lab will familiarize you with the science and techniques used to make transgenic flies to study circadian rhythms.

  • The Mammalian Timekeeper

    The Mammalian Timekeeper


    (57 min 50 sec) Dr. Takahashi describes the powerful strategies that he and others have harnessed for understanding biological clocks in mammals.

  • PERfect TIMing

    PERfect TIMing


    (57 min 32 sec) Dr. Rosbash discloses how scientists have persuaded Mother Nature to reveal the inner workings of the fruit fly's biological clock.

  • Unwinding Clock Genetics

    Unwinding Clock Genetics


    (56 min 42 sec) Although tiny in size, the fruit fly has had a major impact on our understanding of circadian rhythms.

  • Biology in Four Dimensions

    Biology in Four Dimensions


    (58 min 12 sec) Dr. Joseph Takahashi takes us on an exciting journey into a very special region of the brain—the biological clock that governs our physiology and certain behaviors.

  • Clockwork Genes: Discoveries in Biological Time

    Clockwork Genes: Discoveries in Biological Time


    Four lectures highlight the research of two scientists who have made groundbreaking discoveries elucidating the molecular basis of circadian clocks—the internal timekeepers that govern fluctuations in behavior and physiology on a 24-hour cycle.

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