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Showing 41-52 of 52 Resources
  • Learning from Patients: The Science of Medicine

    Learning from Patients: The Science of Medicine

    Lecture

    As part of the 2003 Holiday Lectures on Science, Dr. Bert Vogelstein and Dr. Huda Y. Zoghbi discuss how their patients have led to a deeper understanding of the genetic and molecular bases of neurological disorders and cancer. Thanks to these patients, researchers can now apply the knowledge gained to diagnosis, prevention, and the search for cures.

  • SCA1 Mouse on Rotarod

    SCA1 Mouse on Rotarod

    Clip

    (35 sec) Dr. Zoghbi demonstrates how mice that have been given the gene responsible for spinocerebellar ataxia 1 (SCA1) are tested on a device called a rotarod to quantify the amount of ataxia present.

  • Gleevec

    Gleevec

    Animation

    (1 min 4 sec) Gleevec is a drug designed to interfere with the stimulation of growth in leukemia cells. This 3D animation shows how this is achieved.

  • Exclusion Mapping

    Exclusion Mapping

    Animation

    (32 sec) A useful technique for narrowing down the location of a gene involves comparing the chromosomes of affected siblings. Two sisters with Rett syndrome allow researchers an opportunity to map the most likely location of the gene by excluding areas of the chromosome that are not alike.

  • Sickle Cell Anemia

    Sickle Cell Anemia

    Animation

    (1 min) Sickle cell anemia is a genetic disease that affects hemoglobin.

  • Tri Nucleotide Repeat

    Tri Nucleotide Repeat

    Animation

    (1 min 8 sec) Slippage during DNA replication can lead to expanding sections of repeating nucleotides. Watch this animation to see how this problem occurs. 

  • Cardiology Virtual Lab

    Cardiology Virtual Lab

    Virtual Lab

    NEW! HTML 5 support added! This virtual lab will familiarize you with heritable diseases of the heart. Learn about the diagnostic tools used to examine and diagnose patients.

  • The Kidney's Tale: Of Salt and Hypertension

    The Kidney's Tale: Of Salt and Hypertension

    Lecture

    (1 hr 3 sec) Molecular genetic approaches have identified genes that, when mutated, cause either increased or decreased blood pressure.

  • Heartbreak: Of Mutations and Maladies

    Heartbreak: Of Mutations and Maladies

    Lecture

    (58 min 28 sec) Although heart disease typically occurs after middle age, seemingly fit and healthy young individuals can die suddenly from unrecognized heart disease.

  • Telltale Genes: Charting Human Disease

    Telltale Genes: Charting Human Disease

    Lecture

    (59 min 40 sec) The discovery of DNA as the basis of heredity led to an explosive growth of knowledge about the human genome and allowed the identification of genes that predispose people to different diseases.

  • Of Hearts and Hypertension: Blazing Genetic Trails

    Of Hearts and Hypertension: Blazing Genetic Trails

    Lecture

    In four lectures, Richard P. Lifton, MD, PhD, and Christine E. Seidman, MD, discuss their groundbreaking work in using genetic and molecular approaches to understand cardiovascular diseases.

  • Senses and Sensitivity: Neuronal Alliances for Sight and Sound

    Senses and Sensitivity: Neuronal Alliances for Sight and Sound

    Lecture

    In four talks, A. James Hudspeth, MD, PhD, and Jeremy H. Nathans, MD, PhD, discuss how sensory information is encoded and transmitted to the brain. They describe the detailed workings of two senses of great importance to humans—vision and hearing.

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