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Showing 1-49 of 49 Resources
  • Evolution At Warp Speed

    Evolution At Warp Speed

    Image of the Week

    Understanding the mechanisms of antibiotic resistance by bacteria is essential in the war against scary superbugs.

  • Central Dogma and Genetic Medicine

    Central Dogma and Genetic Medicine

    Click & Learn

    This interactive uses the central dogma as a model for exploring how modern molecular biology technologies can be used to treat genetic diseases.

  • Genetic Mutations and Disease Interactive

    Genetic Mutations and Disease Interactive

    Click & Learn

    This interactive focuses on the roles of germline and somatic cell mutations in human disease. It supports the 2013 Holiday Lectures on Science, Medicine in the Genomic Era.

  • Alzheimer’s Disease: Piecing Together the Evidence

    Alzheimer’s Disease: Piecing Together the Evidence

    Click & Learn

    This interactive explores evidence from brain anatomy, tissue histology, and genetic studies to reveal possible targets for the treatment of Alzheimer’s disease.

  • Origin of a Gene Mutation Causing Early-Onset Alzheimer’s Disease

    Origin of a Gene Mutation Causing Early-Onset Alzheimer’s Disease

    Data Point

    A team of scientists built a pedigree of a large extended family in Antioquia, Colombia, that has a high prevalence of early-onset familial Alzheimer’s disease due to a mutation in the PSEN1 gene. Worksheets also available in Spanish.

  • Plaque Attack

    Plaque Attack

    Image of the Week

    An amyloid plaque (in purple) is surrounded by branches of damaged neurons (multiple colors) in the brain of a mouse with Alzheimer’s disease.

  • Identifying Autism Genes by Tracking Gene Mutations

    Identifying Autism Genes by Tracking Gene Mutations

    Data Point

    A team of scientists used homozygosity mapping to map SNPs on chromosome 3 in a family with an autistic son to identify a likely gene that caused the disorder.

  • Cancer Evolution

    Cancer Evolution

    Image of the Week

    A computer simulation of cancer growth, in which cell colors correspond to different mutations, reveals that a tumor mass is a mixture of genetically similar cells.

  • Reckless Growth

    Reckless Growth

    Image of the Week

    The organization of cells in a healthy mouse intestine is lost in a growing tumor.

  • The Eukaryotic Cell Cycle and Cancer

    The Eukaryotic Cell Cycle and Cancer

    Click & Learn

    Explore the phases, checkpoints, and protein regulators of the cell cycle in this highly interactive Click and Learn and find out how mutated versions of these proteins can lead to the development of cancer. Also available in Spanish.

  • Cancer Discovery Activities

    Cancer Discovery Activities

    Activity

    These two hands-on activities are based on a Howard Hughes Medical Institute 2013 Holiday Lectures on Science video featuring researcher Dr. Charles L. Sawyers. Also available in Spanish.

  • Cancer as a Genetic Disease: Video Highlights

    Cancer as a Genetic Disease: Video Highlights

    Clip

    (8 min 32 sec) In this video Dr. Charles Sawyers provides an overview of the types of genes that, when mutated, can lead to the development of cancer. Also available in Spanish.

  • Dante's Story

    Dante's Story

    Clip

    (6 min 6 sec) Dante is a 10-year-old boy born with hemimegalencephaly—an enlargement of half his brain.

  • Meet Dante—A Young Boy with Hemimegalencephaly

    Meet Dante—A Young Boy with Hemimegalencephaly

    Clip

    (2 min 33 sec) Dante is a healthy 10-year-old boy who has had half his cerebral cortex surgically removed to treat his seizures.

  • Autism and the Structure and Function of Synapses

    Autism and the Structure and Function of Synapses

    Animation

    (2 min 3 sec) Genes associated with autism affect the structure and function of neuronal synapses.

  • Genomic Medicine, Autism, and Cancer

    Genomic Medicine, Autism, and Cancer

    Lecture

    (37 min 26 sec) A student discussion with the lecturers of the 2013 Holiday Lectures on Science.

  • Decoding the Autism Puzzle

    Decoding the Autism Puzzle

    Lecture

    (58 min 5 sec) Over the past decade, the application of advanced DNA sequencing techniques has greatly increased our understanding of the genetic basis of autism.

  • Cancer As a Genetic Disease

    Cancer As a Genetic Disease

    Lecture

    (58 min 33 sec) Understanding that cancer is caused by mutations in genes that regulate cell proliferation has led to the development of targeted drug therapies.

  • Sizing Up the Brain Gene By Gene

    Sizing Up the Brain Gene By Gene

    Lecture

    (59 min 32 sec) Recent advances in DNA sequencing technology have led to a better understanding of the many genes that play a role in brain development.

  • Gleevec-Resistant Form of Kinase BCR-ABL

    Gleevec-Resistant Form of Kinase BCR-ABL

    Animation

    (2 min 14 sec) Mutations in the BCR-ABL gene can cause resistance to Gleevec, but another drug, dasatinib, can be used instead.

  • Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Animation

    (3 min 31 sec) The drug Gleevec binds to and inactivates BCR-ABL, a mutant kinase that causes chronic myeloid leukemia. 

  • Genetic Mutations and Disease

    Genetic Mutations and Disease

    Poster

    The poster for the 2013 Holiday Lectures on Science, Medicine in the Genomic Era, illustrates the difference between germline and somatic cell mutations.

  • Medicine in the Genomic Era

    Medicine in the Genomic Era

    Lecture

    In the 2013 Holiday Lectures on Science, leading medical researchers explain how advances in genomics are revolutionizing their work, leading to a better understanding of disease and to improved treatments.

  • Teacher Guide: Gene Regulation

    Teacher Guide: Gene Regulation

    Teacher Guide

    Topics include: Gene regulation mechanisms and examples, gene regulation and human disease, and RNA interference.

  • Testing a Hypothesis

    Testing a Hypothesis

    Activity

    A worksheet designed to actively engage students as they watch the film. Students are asked to answer questions pertaining to the information provided in the film.

  • The Making of the Fittest: Natural Selection in Humans

    The Making of the Fittest: Natural Selection in Humans

    Short Film

    (14 min 3 sec) In some parts of the world, there is an intimate connection between the infectious parasitic disease malaria and the genetic disease sickle cell anemia. Also available in Spanish

  • How Do Fibers Form?

    How Do Fibers Form?

    Activity

    A hands-on activity in which students construct models of sickle-cell hemoglobin fibers inside red blood cells to illustrate how changes in the structure of a protein can affect cell shape. Students are then asked to relate these changes to disease symptoms. Also available in Spanish.

  • Film Guides: Natural Selection in Humans

    Film Guides: Natural Selection in Humans

    Film Guide

    The following classroom-ready resources complement The Making of the Fittest: Natural Selection in Humans, which describes the connection between malaria and sickle cell anemia—one of the best-understood examples of natural selection in humans. Also available in Spanish.

  • The Molecular Evolution of Gene Birth and Death

    The Molecular Evolution of Gene Birth and Death

    Activity

    An advanced lesson that describes the role of mutations in the birth and death of genes. It includes background information, examples, video clips, and animations.

  • Origin of HIV

    Origin of HIV

    Clip

    (5 min 32 sec) Dr. Beatrice Hahn's research has traced the origin of HIV to chimpanzees in Cameroon.

  • Exploring Obesity: From the Depths of the Brain to the Far Pacific

    Exploring Obesity: From the Depths of the Brain to the Far Pacific

    Lecture

    (58 min 29 sec) Dr. Friedman shows how leptin rewires neural circuits, and how population studies may identify obesity genes.

  • Deconstructing Obesity

    Deconstructing Obesity

    Lecture

    (58 min 20 sec) Dr. Friedman introduces the genes and circuits that control appetite, including the key role of leptin.

  • Classroom Activities: Pedigree Analysis Activity

    Classroom Activities: Pedigree Analysis Activity

    Activity

    To accompany the lecture series Learning from Patients: The Science of Medicine.

  • The Strength of Families: Solving Rett Syndrome

    The Strength of Families: Solving Rett Syndrome

    Lecture

    (58 min 32 sec) Girls with Rett syndrome develop normally for about 18 months and then begin to regress. With the help of affected girls and their families, Dr. Zoghbi and her collaborators searched for the gene responsible for this neurological disorder.

  • A Healthy Nervous System: A Delicate Balance

    A Healthy Nervous System: A Delicate Balance

    Lecture

    (58 min 32 sec) Mutations in key genes can lay waste to the nervous system. By studying large families predisposed to developing these genetic disorders, scientists can identify the responsible altered gene.

  • Chaos to Cure: Bringing Basic Research to Patients

    Chaos to Cure: Bringing Basic Research to Patients

    Lecture

    (58 min 32 sec) The identification of hundreds of genes involved in the formation and spread of cancer is leading to promising new methods for diagnosis, prevention, and treatment.

  • Research Mechanics: Putting the Brakes on Cancer

    Research Mechanics: Putting the Brakes on Cancer

    Lecture

    (58 min 32 sec) Although there are numerous kinds of cancer, all stem from alterations that allow cell division to outstrip cell demise.

  • Learning from Patients: The Science of Medicine

    Learning from Patients: The Science of Medicine

    Lecture

    As part of the 2003 Holiday Lectures on Science, Dr. Bert Vogelstein and Dr. Huda Y. Zoghbi discuss how their patients have led to a deeper understanding of the genetic and molecular bases of neurological disorders and cancer. Thanks to these patients, researchers can now apply the knowledge gained to diagnosis, prevention, and the search for cures.

  • SCA1 Mouse on Rotarod

    SCA1 Mouse on Rotarod

    Clip

    (35 sec) Dr. Zoghbi demonstrates how mice that have been given the gene responsible for spinocerebellar ataxia 1 (SCA1) are tested on a device called a rotarod to quantify the amount of ataxia present.

  • Gleevec

    Gleevec

    Animation

    (1 min 4 sec) Gleevec is a drug designed to interfere with the stimulation of growth in leukemia cells. This 3D animation shows how this is achieved.

  • Exclusion Mapping

    Exclusion Mapping

    Animation

    (32 sec) A useful technique for narrowing down the location of a gene involves comparing the chromosomes of affected siblings. Two sisters with Rett syndrome allow researchers an opportunity to map the most likely location of the gene by excluding areas of the chromosome that are not alike.

  • Sickle Cell Anemia

    Sickle Cell Anemia

    Animation

    (1 min) Sickle cell anemia is a genetic disease that affects hemoglobin.

  • Tri Nucleotide Repeat

    Tri Nucleotide Repeat

    Animation

    (1 min 8 sec) Slippage during DNA replication can lead to expanding sections of repeating nucleotides. Watch this animation to see how this problem occurs. 

  • Cardiology Virtual Lab

    Cardiology Virtual Lab

    Virtual Lab

    NEW! HTML 5 support added! This virtual lab will familiarize you with heritable diseases of the heart. Learn about the diagnostic tools used to examine and diagnose patients.

  • The Kidney's Tale: Of Salt and Hypertension

    The Kidney's Tale: Of Salt and Hypertension

    Lecture

    (1 hr 3 sec) Molecular genetic approaches have identified genes that, when mutated, cause either increased or decreased blood pressure.

  • Heartbreak: Of Mutations and Maladies

    Heartbreak: Of Mutations and Maladies

    Lecture

    (58 min 28 sec) Although heart disease typically occurs after middle age, seemingly fit and healthy young individuals can die suddenly from unrecognized heart disease.

  • Telltale Genes: Charting Human Disease

    Telltale Genes: Charting Human Disease

    Lecture

    (59 min 40 sec) The discovery of DNA as the basis of heredity led to an explosive growth of knowledge about the human genome and allowed the identification of genes that predispose people to different diseases.

  • Of Hearts and Hypertension: Blazing Genetic Trails

    Of Hearts and Hypertension: Blazing Genetic Trails

    Lecture

    In four lectures, Richard P. Lifton, MD, PhD, and Christine E. Seidman, MD, discuss their groundbreaking work in using genetic and molecular approaches to understand cardiovascular diseases.

  • Senses and Sensitivity: Neuronal Alliances for Sight and Sound

    Senses and Sensitivity: Neuronal Alliances for Sight and Sound

    Lecture

    In four talks, A. James Hudspeth, MD, PhD, and Jeremy H. Nathans, MD, PhD, discuss how sensory information is encoded and transmitted to the brain. They describe the detailed workings of two senses of great importance to humans—vision and hearing.

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