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  • Natural Selection in an Outbreak

    Natural Selection in an Outbreak

    Scientists at Work

    (7 min 29 sec) This video brings us to the front lines of the 2013–2015 Ebola outbreak in west Africa and explains how scientists monitored the evolution of the virus by analyzing its genome.

  • Identifying Autism Genes by Tracking Gene Mutations

    Identifying Autism Genes by Tracking Gene Mutations

    Data Point

    A team of scientists used homozygosity mapping to map SNPs on chromosome 3 in a family with an autistic son to identify a likely gene that caused the disorder.

  • Holiday Lecture 2004 Update—Jeff Friedman

    Holiday Lecture 2004 Update—Jeff Friedman

    Clip

    (3 min 52 sec) HHMI investigator Jeff Friedman provides an update to his 2004 lectures on obesity.

  • Mapping Genes to Traits in Dogs Using SNPs

    Mapping Genes to Traits in Dogs Using SNPs

    Activity

    In this hands-on genetic mapping activity students identify single nucleotide polymorphisms (SNPs) correlated with different traits in dogs.

  • DNA Sequence Technology Improves Cancer Treatment

    DNA Sequence Technology Improves Cancer Treatment

    Clip

    (2 min 6 sec) Dr. Charles Sawyers discusses how the identification of most cancer genes could transform cancer into a chronic disease.

  • The Search for Genetic Mutations that Cause Autism

    The Search for Genetic Mutations that Cause Autism

    Clip

    (2 min 5 sec) Dr. Christopher Walsh discusses how genomic science has made enormous contributions to our understanding of the genetic causes of autism.

  • Interview with Jenny Yawei Yang

    Interview with Jenny Yawei Yang

    Interview

    (2 min 35 sec) Ms. Yang describes what it was like growing up in a family filled with medical doctors, discusses her MD-PhD program, and provides advice to high school students interested in science.

  • Interview with Charles Sawyers, MD

    Interview with Charles Sawyers, MD

    Interview

    (5 min 51 sec) Dr. Sawyers describes how he became interested in science during medical school, and offers advice to science students.

  • Interview with Christopher Walsh, MD, PhD

    Interview with Christopher Walsh, MD, PhD

    Interview

    (4 min 43 sec) Dr. Walsh recalls his childhood as one of eight siblings, discovering science in college, and the role of genomics in studying autism.

  • Dog Genomics and Dogs as Model Organisms

    Dog Genomics and Dogs as Model Organisms

    Lecture

    (28 min 54 sec) Dr. Elinor Karlsson discusses her work with dogs as a model organism for genomic studies.

  • Genomic Medicine, Autism, and Cancer

    Genomic Medicine, Autism, and Cancer

    Lecture

    (37 min 26 sec) A student discussion with the lecturers of the 2013 Holiday Lectures on Science.

  • From Cancer Genomics to Cancer Drugs

    From Cancer Genomics to Cancer Drugs

    Lecture

    (58 min 46 sec) Genetic data from a large number of tumor types reveal commonly mutated genes and uncover connections between different types of cancer.

  • Decoding the Autism Puzzle

    Decoding the Autism Puzzle

    Lecture

    (58 min 5 sec) Over the past decade, the application of advanced DNA sequencing techniques has greatly increased our understanding of the genetic basis of autism.

  • Sizing Up the Brain Gene By Gene

    Sizing Up the Brain Gene By Gene

    Lecture

    (59 min 32 sec) Recent advances in DNA sequencing technology have led to a better understanding of the many genes that play a role in brain development.

  • Meet Charles Sawyers

    Meet Charles Sawyers

    Clip

    (2 min 27 sec) Dr. Sawyers is an HHMI investigator who has contributed to the development of drugs that target leukemia and prostate cancer. 

  • Meet Chris Walsh

    Meet Chris Walsh

    Clip

    (2 min 3 sec) Dr. Walsh is an HHMI investigator whose research focuses on understanding the genes involved in the development and function of the human brain.

  • Medicine in the Genomic Era

    Medicine in the Genomic Era

    Lecture

    In the 2013 Holiday Lectures on Science, leading medical researchers explain how advances in genomics are revolutionizing their work, leading to a better understanding of disease and to improved treatments.

  • Genetics of Human Origins and Adaptation

    Genetics of Human Origins and Adaptation

    Lecture

    (58 min 31 sec) Genetic evidence shows that humans evolved in Africa and continue to evolve.

  • Solving SARS and Other Viral Mysteries

    Solving SARS and Other Viral Mysteries

    Lecture

    (58 min 33 sec) The SARS epidemic was successfully halted by a global research effort to identify a new virus.

  • The Virus Hunter's Toolkit

    The Virus Hunter's Toolkit

    Lecture

    (58 min 33 sec) New technologies like the Virochip harness DNA's properties to identify and fight new viruses.

  • Interview with Katherine Sorber

    Interview with Katherine Sorber

    Interview

    (4 min 24 sec) Katherine Sorber, a graduate student in the DeRisi lab, describes her research on malaria.

  • Leading-Edge Bioinformatics

    Leading-Edge Bioinformatics

    Clip

    (6 min 36 sec) Peter Skewes-Cox, and Dr. Graham Ruby, both in the DeRisi lab, explain state-of-the-art DNA sequencing and bioinformatic technologies.

  • Exploring Obesity: From the Depths of the Brain to the Far Pacific

    Exploring Obesity: From the Depths of the Brain to the Far Pacific

    Lecture

    (58 min 29 sec) Dr. Friedman shows how leptin rewires neural circuits, and how population studies may identify obesity genes.

  • Bioethics Discussion

    Bioethics Discussion

    Lecture

    (39 min 44 sec) Genetic research benefits health, but also raises thorny ethical issues.

  • Shotgun sequencing

    Shotgun sequencing

    Animation

    (1 min) In shotgun sequencing many copies of the entire genome are "blown up" into millions of small fragments. Each small fragment is sequenced. Powerful computers then assemble the individual fragments into the original configuration. Repeat sequences pose a problem for this approach because their sizes can be much larger than the small fragments.

  • Human genome sequencing

    Human genome sequencing

    Animation

    (1 min 49 sec) The public Human Genome Project started by identifying unique marker sequences distributed throughout the genome. Then, many copies of a small section of DNA were randomly cleaved into smaller fragments, and each small fragment was sequenced. Because there were originally many copies of the DNA in question, many fragments represented the same part of the genome. These were aligned by identifying overlapping regions of the sequence, and then they were assembled into the original DNA.

  • Using DNA to Trace Human Migration

    Using DNA to Trace Human Migration

    Click & Learn

    All living humans originated from populations of ancestors who migrated out of Africa less than 100,000 years ago. Learn how scientists have used genetic markers to trace the migration routes and origins of modern human populations.

  • How to Analyze DNA Microarray Data

    How to Analyze DNA Microarray Data

    Click & Learn

    DNA microarrays, or gene chips, are an important new technology for genomic research. Learn how researchers use computing to analyze and interpret the huge datasets generated by microarray experiments.

  • Microarray Manufacturing Technology

    Microarray Manufacturing Technology

    Click & Learn

    How both gene chips and microarray slides are created.

  • Discussion Session: Teacher discussion

    Discussion Session: Teacher discussion

    Lecture

    (43 min 24 sec) A wide-ranging 45-minute discussion between Dr. Eric Lander, Dr. Stuart Schreiber, and four Washington DC-area high school teachers.

  • Chemical Genomics: New Tools for Medicine

    Chemical Genomics: New Tools for Medicine

    Lecture

    (58 min 29 sec) Scientists now have the ability to create millions of new molecules. How do they test whether any of these molecules are useful?

  • Human Genomics: A New Guide for Medicine

    Human Genomics: A New Guide for Medicine

    Lecture

    (58 min 35 sec) Dr. Lander explores human genetic variation and how it may affect individual susceptibility to certain diseases.

  • Probing Genes and Genomes

    Probing Genes and Genomes

    Lecture

    (58 min) To understand life's processes, perturb them. How a process responds to an insult can provide clues about normal function or mimic a specific disease state.

  • Reading Genes and Genomes

    Reading Genes and Genomes

    Lecture

    (58 min 9 sec) Dr. Eric Lander takes us on a tour of this remarkable genetic century, describing the rapid advances in DNA sequencing technologies and information science.

  • Scanning Life's Matrix: Genes, Proteins, and Small Molecules

    Scanning Life's Matrix: Genes, Proteins, and Small Molecules

    Lecture

    In four presentations, Stuart L. Schreiber, PhD, and Eric S. Lander, PhD, open a window onto the fast-paced world of genomic science and chemical genetics.

  • Microarrayer In Action

    Microarrayer In Action

    Clip

    (2 min) How a microarraying robot delivers hundreds of small molecules to a series of slides.

  • Gene Chip Manufacturing

    Gene Chip Manufacturing

    Animation

    (1 min 57 sec) Gene chips, also called DNA microarrays, have a broad range of applications in current research, including enabling researchers to measure the activity of thousands of genes simultaneously. Dr. Eric Lander describes the process used to manufacture gene chips.

  • Molecular Screening

    Molecular Screening

    Animation

    (38 sec) After a chemical biologist has made many novel small molecules by diversity-oriented synthesis, the next step is to find those that are useful. Molecules need to be "screened." Conceptually, screening is like using proteins as a custom filter to catch potentially useful small molecules.

  • The Microbes Strike Back

    The Microbes Strike Back

    Lecture

    (58 min 35 sec) Dr. Brett Finlay explains why bacterial diseases continue to be a major health problem worldwide, causing a third of the world's deaths every year.

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