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  • Pitx1 Expression

    Pitx1 Expression

    Animation

    (55 sec) In the stickleback fish, pelvic-fin reduction resulted from changes in the regulatory switch elements of the Pitx1 gene. In the marine ancestor, the Pitx1 gene is activated in the pelvic-fin region during development to generate the fin. In the pelvic-reduced stickleback, the regulatory switch that normally turns on the Pitx1 gene is either missing or non-functional.

  • Wing Morph

    Wing Morph

    Animation

    (29 sec) This "morph" animation demonstrates how the expression of a particular toolkit gene in a butterfly larva corresponds to the location of the wing eyespots in an adult butterfly.

  • Balancing the Fat Equation

    Balancing the Fat Equation

    Lecture

    (58 min 20 sec) Dr. Evans reviews how PPARs regulate body weight by controlling whether fat is burned or stored.

  • PPAR-delta Activation in the Muscle Cell

    PPAR-delta Activation in the Muscle Cell

    Animation

    (1 min 45 sec) The PPAR-delta receptor activates certain genes in a muscle cell, resulting in the burning of fat.

  • PPAR-gamma Activation in the Fat Cell

    PPAR-gamma Activation in the Fat Cell

    Animation

    (2 min 49 sec) The PPAR-gamma receptor activates certain genes in a fat cell, resulting in the storage of fat and changes in hormone levels.

  • The Strength of Families: Solving Rett Syndrome

    The Strength of Families: Solving Rett Syndrome

    Lecture

    (58 min 32 sec) Girls with Rett syndrome develop normally for about 18 months and then begin to regress. With the help of affected girls and their families, Dr. Zoghbi and her collaborators searched for the gene responsible for this neurological disorder.

  • MECP2

    MECP2

    Animation

    (43 sec) This animation shows how the protein MECP2, in conjuction with another protein complex, can act as an "on-off' switch for gene expression.

  • p53

    p53

    Animation

    (26 sec) A 3D animation showing the molecule p53 binds to DNA and initiates the transcription of mRNA.

  • X Inactivation

    X Inactivation

    Animation

    (55 sec) This animation shows how the random deactivation of one of the X chromosomes in a pair can lead to a mozaicism in the expression genes. 

  • Sex and Death: Too Much of a Good Thing

    Sex and Death: Too Much of a Good Thing

    Lecture

    (59 min 6 sec) Having too many chromosomes can lead to too much gene expression. Dr. Meyer explains how the gene that controls dosage compensation in C. elegans works.

  • Hermaphrodites: The Safer Sex

    Hermaphrodites: The Safer Sex

    Lecture

    (56 min 32 sec) Dr. Barbara Meyer explains the value of studying model organisms and introduces the nematode C. elegans.

  • The Meaning of Sex: Genes and Gender

    The Meaning of Sex: Genes and Gender

    Lecture

    Four talks focus on sex determination—the molecular and genetic mechanisms that determine whether an organism will be male, female or a hermaphrodite.

  • Regulation of Sex Determination in C. elegans

    Regulation of Sex Determination in C. elegans

    Clip

    (6 min 4 sec) A demonstration by Dr. Meyer showing how a balance of molecular elements trigger genetic pathways that determine the sex of a C. elegans worm.

  • MIX-1

    MIX-1

    Animation

    (3 min 39 sec) This animation shows how MIX-1 facilitates both chromosome condensation and dosage compensation.

  • Clockwork Genes: Discoveries in Biological Time

    Clockwork Genes: Discoveries in Biological Time

    Lecture

    Four lectures highlight the research of two scientists who have made groundbreaking discoveries elucidating the molecular basis of circadian clocks—the internal timekeepers that govern fluctuations in behavior and physiology on a 24-hour cycle.

  • Interview with Dr. Ron Konopka

    Interview with Dr. Ron Konopka

    Interview

    (44 sec) Dr. Benzer is joined by Dr. Ron Konopka for a brief discussion of how the per gene is involved in mammalian clocks.

  • The Drosophila Molecular Clock Model

    The Drosophila Molecular Clock Model

    Animation

    (7 min 35 sec) Watch these animations display the dynamic orchestration of the molecular events of the Drosophila biological clock.

  • The Mammalian Molecular Clock Model

    The Mammalian Molecular Clock Model

    Animation

    (3 min 41 sec) This animation shows the molecular interactions involved in the negative feedback loop responsible for circadian rhythms in mammals.

  • RNA Interference

    RNA Interference

    Click & Learn

    RNA interference is an exciting new research tool for shutting down genes. It could also yield new medical treatments.

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