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Showing 1-25 of 25 Resources
  • Teacher Guides

    Teacher Guides

    Collection

    Designed by educators, BioInteractive’s teacher guides will help you select BioInteractive resources aligned to specific topics and standards, including the AP® Biology Curriculum Framework.

  • A Model Microbe

    A Model Microbe

    Image of the Week

    Tetrahymena thermophila is a freshwater unicellular ciliated protozoan related to Paramecium.

  • Dengue Fever

    Dengue Fever

    Image of the Week

    A 3D model of the dengue virus reveals a shape like a soccer ball with an outer coating of glycoproteins.

  • Teacher Guide: Gene Regulation

    Teacher Guide: Gene Regulation

    Teacher Guide

    Topics include: Gene regulation mechanisms and examples, gene regulation and human disease, and RNA interference.

  • Teacher Guide: Gene Expression

    Teacher Guide: Gene Expression

    Teacher Guide

    Topics include: Gene expression, RNA structure and function, transcription, RNA processing, translation, and post-translational events.

  • Regulation of Eukaryotic DNA Transcription

    Regulation of Eukaryotic DNA Transcription

    Animation

    (2 min 5 sec) General transcription factors, activators, and repressors interact to regulate the transcription of eukaryotic DNA into RNA.

  • Dengue Virus Life Cycle

    Dengue Virus Life Cycle

    Animation

    (4 min 12 sec) Dengue virus has sophisticated mechanisms for entering a cell, for replicating its RNA genome, and for translating proteins.

  • HIV life cycle

    HIV life cycle

    Animation

    (4 min 52 sec) How HIV infects a cell and replicates itself using reverse transcriptase and the host's cellular machinery.

  • AZT blocks reverse transcriptase

    AZT blocks reverse transcriptase

    Animation

    (1 min 46 sec) HIV's reverse transcriptase mistakes AZT for thymidine. Once incorporated, AZT stops reverse transcription.

  • Translation (advanced detail)

    Translation (advanced detail)

    Animation

    (3 min 4 sec) Messenger RNA (mRNA) carries DNA's genetic information to the ribosome, where it is translated into a sequence of amino acids. mRNA is fed into the ribosome, and it is positioned so that it can be read in groups of three letters, known as codons. Each mRNA codon is matched against the transfer RNA molecule's anti-codon. If there is a match, the amino acid carried by the transfer RNA is added to the growing protein chain. Also available in Spanish.

  • Translation (basic detail)

    Translation (basic detail)

    Animation

    (2 min 6 sec) The ribosome is a molecular factory that translates the genetic information in RNA into a string of amino acids that becomes a protein. Inside the ribosome, the genetic code of the RNA is read three letters at a time and compared with the corresponding code on a transfer molecule. When a match occurs between the codes, the amino acid carried by the transfer molecule is added to the growing protein chain. Also available in Spanish.

  • DNA transcription (advanced detail)

    DNA transcription (advanced detail)

    Animation

    (1 min 55 sec) The process of copying DNA into messenger RNA (mRNA) is called transcription. Transcription factors assemble at the promoter region of a gene, bringing an RNA polymerase enzyme to form the transcription initiation complex. Activator proteins at the enhancer region of DNA then activate the transcription initiation complex. RNA polymerase unzips a small portion of the DNA and copies one strand into an mRNA molecule. Also available in Spanish.

  • DNA transcription (basic detail)

    DNA transcription (basic detail)

    Animation

    (1 min 55 sec) The first phase of the process of reading DNA information to make proteins starts with a molecule unzipping the DNA. The molecule then copies one of the strands of DNA into a strand of RNA, a close cousin of DNA. This process is called transcription. Also available in Spanish.

  • mRNA splicing

    mRNA splicing

    Animation

    (39 sec) Once a gene has been transcribed into messenger RNA (mRNA), it is edited in a process called splicing. Noncoding regions called introns are removed, leaving protein-coding regions called exons.

  • Recombination of Viral Genome

    Recombination of Viral Genome

    Animation

    (3 min 5 sec) When two different strains of influenza infect a single cell, their genetic material can mix freely, resulting in a new third strain of influenza.

  • Structure and Function of Telomeres

    Structure and Function of Telomeres

    Click & Learn

    This mini-lesson covers the research on telomeres that has happened since the 1995 Holiday Lectures.

  • RNA Diversity

    RNA Diversity

    Click & Learn

    RNA is an information molecule that can also function as an enzyme. Learn about the many different forms that RNA can take.

  • RNA Interference

    RNA Interference

    Click & Learn

    RNA interference is an exciting new research tool for shutting down genes. It could also yield new medical treatments.

  • Life at the End of the Chromosome: Another RNA Machine

    Life at the End of the Chromosome: Another RNA Machine

    Lecture

    (58 min 20 sec) The chromosome ends, or telomeres, are necessary for DNA stability and replication.

  • How to Accelerate a Reaction 100,000,000,000 Times Using Only RNA

    How to Accelerate a Reaction 100,000,000,000 Times Using Only RNA

    Lecture

    (58 min 29 sec) Studies of RNA catalytic centers have revealed much about their structure and mode of action.

  • RNA as an Enzyme: Discovery, Origins of Life, and Medical Possibilities

    RNA as an Enzyme: Discovery, Origins of Life, and Medical Possibilities

    Lecture

    (58 min 22 sec) Discovery of RNA's catalytic activity led to unexpected spin-offs, including a new scenario for the origin of life.

  • Catalysis: Chemical and Biochemical

    Catalysis: Chemical and Biochemical

    Lecture

    (58 min 25 sec) Cellular enzymes are catalysts that tame reactions by accelerating them, lending specificity, and regulating their time and place.

  • The Double Life of RNA

    The Double Life of RNA

    Lecture

    In four lectures, Nobel laureate Thomas R. Cech, PhD, discusses the ability of RNA to act as more than just an intermediary between DNA and proteins.

  • Enzymes That Are Not Proteins: The Discovery of Ribozymes

    Enzymes That Are Not Proteins: The Discovery of Ribozymes

    Clip

    (19 min 4 sec) Listen to past HHMI President Dr. Thomas Cech discussing his Nobel Prize-winning discovery of RNA's catalytic properties.

  • RNA Folding

    RNA Folding

    Animation

    (33 sec) Since RNA is single-stranded, it can fold upon itself and form structures that are protein-like in both appearance and functionality.

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