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  • Classroom Activities: Gene Switches

    Classroom Activities: Gene Switches


    To accompany the lecture series Evolution: Constant Change and Common Threads.

  • Pitx1 Expression

    Pitx1 Expression


    (55 sec) In the stickleback fish, pelvic-fin reduction resulted from changes in the regulatory switch elements of the Pitx1 gene. In the marine ancestor, the Pitx1 gene is activated in the pelvic-fin region during development to generate the fin. In the pelvic-reduced stickleback, the regulatory switch that normally turns on the Pitx1 gene is either missing or non-functional.