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  • Cell Division and Cancer Risk

    Cell Division and Cancer Risk

    Data Point

    Cancer is typically attributed to hereditary and environmental factors, but these only explain a fraction of overall cancer risk. In this study, researchers investigated how a third factor—chance genetic mutations that occur during stem cell division—may contribute to the overall rate of cancer incidence in different body tissues.

  • Sound and Vision

    Sound and Vision

    Image of the Week

    A mass of cells surrounded by blood vessels visualized in a living mouse using photoacoustic imaging.

  • Efficacy of a Treatment for Chronic Myeloid Leukemia

    Efficacy of a Treatment for Chronic Myeloid Leukemia

    Data Point

    Dr. Brian Druker and colleagues monitored white blood cell counts in six patients with chronic myeloid leukemia treated with the drug, STI571, which blocks the activity of the cancer-causing tyrosine kinase BCR-ABL.

  • Cancer Evolution

    Cancer Evolution

    Image of the Week

    A computer simulation of cancer growth, in which cell colors correspond to different mutations, reveals that a tumor mass is a mixture of genetically similar cells.

  • Reckless Growth

    Reckless Growth

    Image of the Week

    The organization of cells in a healthy mouse intestine is lost in a growing tumor.

  • How We Get Our Skin Color Interactive

    How We Get Our Skin Color Interactive

    Interactive Video

    (3 min 32 sec) This interactive animation about the biology of skin color provides stop points at which students can further explore the material through additional text and illustrations, videos, questions, and simple interactive widgets.

  • The Eukaryotic Cell Cycle and Cancer

    The Eukaryotic Cell Cycle and Cancer

    Click & Learn

    Explore the phases, checkpoints, and protein regulators of the cell cycle in this highly interactive Click and Learn and find out how mutated versions of these proteins can lead to the development of cancer. Also available in Spanish.

  • BCR-ABL: Cancer Protein Structure and Function

    BCR-ABL: Cancer Protein Structure and Function

    Click & Learn

    This Click and Learn describes how understanding the structure of the BCR-ABL kinase led to the development of an effective treatment for chronic myeloid leukemia.

  • Fish Tales

    Fish Tales

    Image of the Week

    Zebrafish blood is generated from stem cells located in the tail region of fish embryos and later from stem cells located in the kidney of the adult fish.

  • Cancer Discovery Activities

    Cancer Discovery Activities

    Activity

    These two hands-on activities are based on a Howard Hughes Medical Institute 2013 Holiday Lectures on Science video featuring researcher Dr. Charles L. Sawyers. Also available in Spanish.

  • Cancer as a Genetic Disease: Video Highlights

    Cancer as a Genetic Disease: Video Highlights

    Clip

    (8 min 32 sec) In this video Dr. Charles Sawyers provides an overview of the types of genes that, when mutated, can lead to the development of cancer. Also available in Spanish.

  • Dasatinib

    Dasatinib

    3D Model

    A 3D model of dasatinib, a drug that can inhibit BCR-ABL and Gleevec-resistant BCR-ABL.


  • Imatinib (Gleevec)

    Imatinib (Gleevec)

    3D Model

    A 3D model of imatinib (Gleevec), a drug that mimics ATP and inhibits BCR-ABL.

  • Adenosine Triphosphate (ATP)

    Adenosine Triphosphate (ATP)

    3D Model

    A 3D model of adenosine triphosphate, or ATP.

  • Gleevec-resistant BCR-ABL: ABL Kinase Domain

    Gleevec-resistant BCR-ABL: ABL Kinase Domain

    3D Model

    A 3D model of gleevec-resistant BCR-ABL, a mutated form of BCR-ABL.

  • BCR-ABL: ABL Kinase Domain

    BCR-ABL: ABL Kinase Domain

    3D Model

    A 3D model of BCR-ABL, an unregulated kinase that causes cancer.

  • DNA Sequence Technology Improves Cancer Treatment

    DNA Sequence Technology Improves Cancer Treatment

    Clip

    (2 min 6 sec) Dr. Charles Sawyers discusses how the identification of most cancer genes could transform cancer into a chronic disease.

  • Cancer and Cell Fate in the Intestinal Epithelium

    Cancer and Cell Fate in the Intestinal Epithelium

    Animation

    (2 min 17 sec) Disrupting the normal processes of differentiation and maturation of the intestinal epithelial cells can lead to cancer. Also available in Spanish.

  • Interview with Minna Balbas

    Interview with Minna Balbas

    Interview

    (3 min 7 sec) Ms. Balbas discusses her early interest in medicine, her path to becoming a researcher, and her best day in the lab.

  • Interview with Charles Sawyers, MD

    Interview with Charles Sawyers, MD

    Interview

    (5 min 51 sec) Dr. Sawyers describes how he became interested in science during medical school, and offers advice to science students.

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