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  • Student Discussion Session on Obesity

    Student Discussion Session on Obesity

    Lecture

    (47 min 48 sec) A Q&A session on obesity and related issues, with the lecturers and students attending the Holiday Lectures on Science.

  • Exploring Obesity: From the Depths of the Brain to the Far Pacific

    Exploring Obesity: From the Depths of the Brain to the Far Pacific

    Lecture

    (58 min 29 sec) Dr. Friedman shows how leptin rewires neural circuits, and how population studies may identify obesity genes.

  • Balancing the Fat Equation

    Balancing the Fat Equation

    Lecture

    (58 min 20 sec) Dr. Evans reviews how PPARs regulate body weight by controlling whether fat is burned or stored.

  • Understanding Fat: Syndrome X and Beyond

    Understanding Fat: Syndrome X and Beyond

    Lecture

    (58 min 29 sec) Dr. Evans describes how fat communicates with muscle and how diet and exercise influence that relationship.

  • Deconstructing Obesity

    Deconstructing Obesity

    Lecture

    (58 min 20 sec) Dr. Friedman introduces the genes and circuits that control appetite, including the key role of leptin.

  • The Science of Fat

    The Science of Fat

    Lecture

    In the 2004 Holiday Lectures on Science, HHMI investigators Ronald M. Evans and Jeffrey M. Friedman discuss how the body regulates weight by carefully controlling the storage and burning of fat—and how a better understanding of these complex metabolic systems could lead researchers to treatments that curb obesity and improve public health. Awards 2006 Telly Awards; Silver