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Showing 1-20 of 23 Resources
  • Identifying the Key Genes for Regeneration

    Identifying the Key Genes for Regeneration

    Scientists at Work

    (9 min 55 sec) Planarians have an amazing ability to regenerate lost tissues. In this video, scientists knock out two different genes in planaria to start to understand how the process works—and they generate animals with two heads and two tails!

  • Dante's Story

    Dante's Story

    Clip

    (6 min 6 sec) Dante is a 10-year-old boy born with hemimegalencephaly—an enlargement of half his brain.

  • The Search for Genetic Mutations that Cause Autism

    The Search for Genetic Mutations that Cause Autism

    Clip

    (2 min 5 sec) Dr. Christopher Walsh discusses how genomic science has made enormous contributions to our understanding of the genetic causes of autism.

  • Meet Dante—A Young Boy with Hemimegalencephaly

    Meet Dante—A Young Boy with Hemimegalencephaly

    Clip

    (2 min 33 sec) Dante is a healthy 10-year-old boy who has had half his cerebral cortex surgically removed to treat his seizures.

  • Sizing Up the Brain Gene By Gene

    Sizing Up the Brain Gene By Gene

    Lecture

    (59 min 32 sec) Recent advances in DNA sequencing technology have led to a better understanding of the many genes that play a role in brain development.

  • Meet Chris Walsh

    Meet Chris Walsh

    Clip

    (2 min 3 sec) Dr. Walsh is an HHMI investigator whose research focuses on understanding the genes involved in the development and function of the human brain.

  • Building Brains: The Molecular Logic of Neural Circuits

    Building Brains: The Molecular Logic of Neural Circuits

    Lecture

    (58 min 29 sec) How a nerve cell gets its identity, sends axons, and makes connections with other cells.

  • Demo: SHH concentration and eye position

    Demo: SHH concentration and eye position

    Clip

    (1 min 22 sec) A reduction in the level of sonic hedgehog (SHH) gene expression can lead to cyclopia.

  • Long-distance neuronal path-finding

    Long-distance neuronal path-finding

    Clip

    (31 sec) Retinal axons travel across the brain, reading navigation cues, to find appropriate targets.

  • Growth cones in action

    Growth cones in action

    Clip

    (34 sec) The growth cones of two neurons sense and interact with one another.

  • Contact repulsion of a growth cone

    Contact repulsion of a growth cone

    Clip

    (1 min 5 sec) A growth cone contacts a repellant molecule on another axon, collapses, and withdraws.

  • Coaxing Embryonic Stem Cells

    Coaxing Embryonic Stem Cells

    Lecture

    (58 min 25 sec) In cloning, a cell's genetic machinery is reprogrammed. Can we similarly coax stem cells to become specific cell types?

  • Understanding Embryonic Stem Cells

    Understanding Embryonic Stem Cells

    Lecture

    (58 min 27 sec) An overview of embryonic development, the progressive differentiation of cells, and properties of embryonic stem cells.

  • Potent Biology: Stem Cells, Cloning, and Regeneration

    Potent Biology: Stem Cells, Cloning, and Regeneration

    Lecture

    Doug Melton and Nadia Rosenthal are leaders in stem cell research, working primarily with mouse and human tissue. They will discuss where embryonic and adult stem cells come from and the biology of how they supply the cells the body needs.

  • Planarian Regeneration and Stem Cells

    Planarian Regeneration and Stem Cells

    Scientists at Work

    (11 min 47 sec) A mini-documentary discussing the remarkable regenerative capabilities of the planarian, and how HHMI researcher Alejandro Sánchez Alvarado uses them to study the biology of stem cells.

  • Rett Syndrome

    Rett Syndrome

    Clip

    (2 min 52 sec) Dr. Zoghbi introduces the topic of Rett syndrome by showing how development usually progresses in a young girl. She then shows an excerpt from Silent Angels, introduced by Julia Roberts, which shows how Rett syndrome affects development.

  • Deciphering the Language of Sex

    Deciphering the Language of Sex

    Lecture

    (58 min 51 sec) Is it a boy or a girl? Dr. David Page looks at how we define male and female and summarizes the development of human sex characteristics.

  • Sperm Motility

    Sperm Motility

    Clip

    (21 sec) Video microscopy of sperm motility in an average human male and an infertile male.

  • Intracytoplasmic Sperm Injection (ICSI)

    Intracytoplasmic Sperm Injection (ICSI)

    Clip

    (1 min 16 sec) Video microscopy demonstrating how sperm from an infertile male can be injected into a female egg.

  • From Fertilization to Egg Laying in C. elegans

    From Fertilization to Egg Laying in C. elegans

    Clip

    (1 min 12 sec) Video of the fertilization of the C. elegans oocyte, the fusion of the egg and sperm nuclei, and the egg laying.