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  • Holiday Lecture 2004 Update—Jeff Friedman

    Holiday Lecture 2004 Update—Jeff Friedman


    (3 min 52 sec) HHMI investigator Jeff Friedman provides an update to his 2004 lectures on obesity.

  • Understanding Fat: Syndrome X and Beyond

    Understanding Fat: Syndrome X and Beyond


    (58 min 29 sec) Dr. Evans describes how fat communicates with muscle and how diet and exercise influence that relationship.

  • Deconstructing Obesity

    Deconstructing Obesity


    (58 min 20 sec) Dr. Friedman introduces the genes and circuits that control appetite, including the key role of leptin.

  • The Science of Fat

    The Science of Fat


    In the 2004 Holiday Lectures on Science, HHMI investigators Ronald M. Evans and Jeffrey M. Friedman discuss how the body regulates weight by carefully controlling the storage and burning of fat—and how a better understanding of these complex metabolic systems could lead researchers to treatments that curb obesity and improve public health. Awards 2006 Telly Awards; Silver

  • Marathon Mouse

    Marathon Mouse


    (53 sec) Dr. Ronald Evans discusses the so-called "marathon" mouse, with a mutation in the PPAR-gamma gene, and its performance on a treadmill relative to a normal mouse.

  • Mouse Activity

    Mouse Activity


    (30 sec) Dr. Evans compares the activity of a normal mouse to one with a mutation in a key gene controlling obesity.

  • Leptin Feedback Control System

    Leptin Feedback Control System


    (1 min 1 sec) Demonstrates how changes in the amount of fat tissue lead to changes in leptin levels and thus changes in appetite.