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Showing 1-15 of 15 Resources
  • Cancer Evolution

    Cancer Evolution

    Image of the Week

    A computer simulation of cancer growth, in which cell colors correspond to different mutations, reveals that a tumor mass is a mixture of genetically similar cells.

  • Reckless Growth

    Reckless Growth

    Image of the Week

    The organization of cells in a healthy mouse intestine is lost in a growing tumor.

  • The Eukaryotic Cell Cycle and Cancer

    The Eukaryotic Cell Cycle and Cancer

    Click & Learn

    Explore the phases, checkpoints, and protein regulators of the cell cycle in this highly interactive Click and Learn and find out how mutated versions of these proteins can lead to the development of cancer. Also available in Spanish.

  • Cancer Discovery Activities

    Cancer Discovery Activities

    Activity

    These two hands-on activities are based on a Howard Hughes Medical Institute 2013 Holiday Lectures on Science video featuring researcher Dr. Charles L. Sawyers. Also available in Spanish.

  • Cancer as a Genetic Disease: Video Highlights

    Cancer as a Genetic Disease: Video Highlights

    Clip

    (8 min 32 sec) In this video Dr. Charles Sawyers provides an overview of the types of genes that, when mutated, can lead to the development of cancer. Also available in Spanish.

  • Genomic Medicine, Autism, and Cancer

    Genomic Medicine, Autism, and Cancer

    Lecture

    (37 min 26 sec) A student discussion with the lecturers of the 2013 Holiday Lectures on Science.

  • Cancer As a Genetic Disease

    Cancer As a Genetic Disease

    Lecture

    (58 min 33 sec) Understanding that cancer is caused by mutations in genes that regulate cell proliferation has led to the development of targeted drug therapies.

  • Gleevec-Resistant Form of Kinase BCR-ABL

    Gleevec-Resistant Form of Kinase BCR-ABL

    Animation

    (2 min 14 sec) Mutations in the BCR-ABL gene can cause resistance to Gleevec, but another drug, dasatinib, can be used instead.

  • Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Animation

    (3 min 31 sec) The drug Gleevec binds to and inactivates BCR-ABL, a mutant kinase that causes chronic myeloid leukemia. 

  • Genetic Mutations and Disease

    Genetic Mutations and Disease

    Poster

    The poster for the 2013 Holiday Lectures on Science, Medicine in the Genomic Era, illustrates the difference between germline and somatic cell mutations.

  • Medicine in the Genomic Era

    Medicine in the Genomic Era

    Lecture

    In the 2013 Holiday Lectures on Science, leading medical researchers explain how advances in genomics are revolutionizing their work, leading to a better understanding of disease and to improved treatments.

  • Chaos to Cure: Bringing Basic Research to Patients

    Chaos to Cure: Bringing Basic Research to Patients

    Lecture

    (58 min 32 sec) The identification of hundreds of genes involved in the formation and spread of cancer is leading to promising new methods for diagnosis, prevention, and treatment.

  • Research Mechanics: Putting the Brakes on Cancer

    Research Mechanics: Putting the Brakes on Cancer

    Lecture

    (58 min 32 sec) Although there are numerous kinds of cancer, all stem from alterations that allow cell division to outstrip cell demise.

  • Learning from Patients: The Science of Medicine

    Learning from Patients: The Science of Medicine

    Lecture

    As part of the 2003 Holiday Lectures on Science, Dr. Bert Vogelstein and Dr. Huda Y. Zoghbi discuss how their patients have led to a deeper understanding of the genetic and molecular bases of neurological disorders and cancer. Thanks to these patients, researchers can now apply the knowledge gained to diagnosis, prevention, and the search for cures.

  • Gleevec

    Gleevec

    Animation

    (1 min 4 sec) Gleevec is a drug designed to interfere with the stimulation of growth in leukemia cells. This 3D animation shows how this is achieved.