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Showing 1-15 of 15 Resources
  • The Search for a Mutated Gene

    The Search for a Mutated Gene

    Scientists at Work

    (8 min 54 sec) How do you identify the disease-causing mutation in a patient with an inherited disease? This video illustrates the steps involved—testing for genes that are the “usual suspects,” searching for mutations in novel genes, and assessing links between genotype and phenotype.

  • DNA Sequence Technology Improves Cancer Treatment

    DNA Sequence Technology Improves Cancer Treatment

    Clip

    (2 min 6 sec) Dr. Charles Sawyers discusses how the identification of most cancer genes could transform cancer into a chronic disease.

  • Solving SARS and Other Viral Mysteries

    Solving SARS and Other Viral Mysteries

    Lecture

    (58 min 33 sec) The SARS epidemic was successfully halted by a global research effort to identify a new virus.

  • The Virus Hunter's Toolkit

    The Virus Hunter's Toolkit

    Lecture

    (58 min 33 sec) New technologies like the Virochip harness DNA's properties to identify and fight new viruses.

  • Shotgun sequencing

    Shotgun sequencing

    Animation

    (1 min) In shotgun sequencing many copies of the entire genome are "blown up" into millions of small fragments. Each small fragment is sequenced. Powerful computers then assemble the individual fragments into the original configuration. Repeat sequences pose a problem for this approach because their sizes can be much larger than the small fragments.

  • How to Analyze DNA Microarray Data

    How to Analyze DNA Microarray Data

    Click & Learn

    DNA microarrays, or gene chips, are an important new technology for genomic research. Learn how researchers use computing to analyze and interpret the huge datasets generated by microarray experiments.

  • Microarray Manufacturing Technology

    Microarray Manufacturing Technology

    Click & Learn

    How both gene chips and microarray slides are created.

  • Chemical Genomics: New Tools for Medicine

    Chemical Genomics: New Tools for Medicine

    Lecture

    (58 min 29 sec) Scientists now have the ability to create millions of new molecules. How do they test whether any of these molecules are useful?

  • Human Genomics: A New Guide for Medicine

    Human Genomics: A New Guide for Medicine

    Lecture

    (58 min 35 sec) Dr. Lander explores human genetic variation and how it may affect individual susceptibility to certain diseases.

  • Probing Genes and Genomes

    Probing Genes and Genomes

    Lecture

    (58 min) To understand life's processes, perturb them. How a process responds to an insult can provide clues about normal function or mimic a specific disease state.

  • Reading Genes and Genomes

    Reading Genes and Genomes

    Lecture

    (58 min 9 sec) Dr. Eric Lander takes us on a tour of this remarkable genetic century, describing the rapid advances in DNA sequencing technologies and information science.

  • Scanning Life's Matrix: Genes, Proteins, and Small Molecules

    Scanning Life's Matrix: Genes, Proteins, and Small Molecules

    Lecture

    In four presentations, Stuart L. Schreiber, PhD, and Eric S. Lander, PhD, open a window onto the fast-paced world of genomic science and chemical genetics.

  • Microarrayer In Action

    Microarrayer In Action

    Clip

    (2 min) How a microarraying robot delivers hundreds of small molecules to a series of slides.

  • Gene Chip Manufacturing

    Gene Chip Manufacturing

    Animation

    (1 min 57 sec) Gene chips, also called DNA microarrays, have a broad range of applications in current research, including enabling researchers to measure the activity of thousands of genes simultaneously. Dr. Eric Lander describes the process used to manufacture gene chips.

  • Molecular Screening

    Molecular Screening

    Animation

    (38 sec) After a chemical biologist has made many novel small molecules by diversity-oriented synthesis, the next step is to find those that are useful. Molecules need to be "screened." Conceptually, screening is like using proteins as a custom filter to catch potentially useful small molecules.