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  • The Deep History of a Living Planet

    The Deep History of a Living Planet

    Lecture

    (1 hr 28 min 29 sec) Microbes have been the dominant life form throughout Earth's history. Eukaryotes and animals evolved only after microbes evolved oxygen-generating photosynthesis.

  • Q&A on Quorum Sensing

    Q&A on Quorum Sensing

    Lecture

    (12 min 59 sec) In this 13-minute Q&A session, Dr. Bonnie Bassler answers questions on quorum sensing and other topics related to bacteria.

  • Eavesdropping on Tiny Conspiracies

    Eavesdropping on Tiny Conspiracies

    Lecture

    (58 min 29 sec) The quorum sensing system is a target for a new class of drugs that interfere with virulence without killing bacteria.

  • Shedding Light on an Invisible World

    Shedding Light on an Invisible World

    Lecture

    (58 min 29 sec) Bacteria are capable of communicating and coordinating their activities with a molecular signaling system called quorum sensing.

  • Exploring Biodiversity: The Search for New Medicines

    Exploring Biodiversity: The Search for New Medicines

    Lecture

    What medical secrets do venomous snails hold? How can listening in on bacterial conversations help develop new antibiotics? In four presentations, Dr. Bonnie L. Bassler and Dr. Baldomero M. Olivera reveal how a deeper understanding of nature and biodiversity informs their research into new medicines.

  • Demonstration: Quorum sensing molecules

    Demonstration: Quorum sensing molecules

    Clip

    (50 sec) Quorum sensing signal molecules have parts that are common between species as well as species-specific parts.

  • Demonstration: Glowing bacteria in a flask

    Demonstration: Glowing bacteria in a flask

    Clip

    (52 sec) Dr. Bassler demonstrates the bioluminescence of a culture of Vibrio harveyi.

  • Outwitting Bacteria's Wily Ways

    Outwitting Bacteria's Wily Ways

    Lecture

    (58 min 54 sec) Dr. Finlay showcases three types of bacteria to illustrate how molecular biology is allowing researchers to probe the molecular workings of bacterial infections.

  • The Microbes Strike Back

    The Microbes Strike Back

    Lecture

    (58 min 35 sec) Dr. Brett Finlay explains why bacterial diseases continue to be a major health problem worldwide, causing a third of the world's deaths every year.

  • 2000 and Beyond: Confronting the Microbe Menace

    2000 and Beyond: Confronting the Microbe Menace

    Lecture

    (57 min 36 sec) In four presentations, Donald E. Ganem, MD, and B. Brett Finlay, PhD, discuss the latest advances in understanding how pathogens invade the body and how this knowledge is leading to the development of new therapies. They also explain how new infectious diseases are recognized and how epidemics arise.

  • Virulence Injection Simulation

    Virulence Injection Simulation

    Clip

    (2 min 1 sec) Using a bagel, a syringe, and blue dye to illustrate how some virulent strains of bacteria inject virulence factors into a cell.

  • Size Analogies of Bacteria and Viruses

    Size Analogies of Bacteria and Viruses

    Clip

    (1 min 44 sec) Dr. Finlay and Dr. Richard Ganem use physical analogies to compare the size of bacteria and viruses relative to a standard mammalian cell.

  • Penicillin acting on bacteria

    Penicillin acting on bacteria

    Clip

    (34 sec) Penicillin, as shown in this video, causes the cell walls of bacteria to rupture.

  • Salmonella Video

    Salmonella Video

    Clip

    (38 sec) Salmonella are a common bacteria associated with food poisoning. Dr. Finlay shows live Salmonella under the microscope to demonstrate how far and fast they can move.

  • Listeria Video

    Listeria Video

    Clip

    (1 min 8 sec) This microscope video shows how live Listeria move via actin filaments in an infected cell.

  • Salmonella Infection Demonstration

    Salmonella Infection Demonstration

    Clip

    (1 min 21 sec) Dr. Finlay and another student volunteer illustrate how Salmonella infects a cell, using a marble, plastic wrap, and some yellow gelatin.

  • Listeria Infection Demonstration

    Listeria Infection Demonstration

    Clip

    (1 min 5 sec) Dr. Finlay and a student volunteer show how Listeria infects a cell, using a marble and some yellow gelatin.

  • Cheek Cells and Bacteria

    Cheek Cells and Bacteria

    Clip

    (1 min 28 sec) Dr. Brett Finlay enlists a student volunteer to show the surprisingly high amount of bacteria found in his own mouth.

  • Bacterial Growth

    Bacterial Growth

    Clip

    (54 sec) Dr. Brett Finlay shows how bacteria can grow rapidly to incredible numbers, and also explains what limits this explosive growth.