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Showing 1-14 of 14 Resources
  • Seeing Single Molecules Move

    Seeing Single Molecules Move


    (1 min 40 sec) Single-molecule analysis using super-resolution microscopes reveals that transcription factors are not usually found bound to their binding sites on DNA.

  • Gleevec-Resistant Form of Kinase BCR-ABL

    Gleevec-Resistant Form of Kinase BCR-ABL


    (2 min 14 sec) Mutations in the BCR-ABL gene can cause resistance to Gleevec, but another drug, dasatinib, can be used instead.

  • Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Gleevec Inhibits Cancer-Causing Kinase BCR-ABL


    (3 min 31 sec) The drug Gleevec binds to and inactivates BCR-ABL, a mutant kinase that causes chronic myeloid leukemia. 

  • Structure of Dengue Virus

    Structure of Dengue Virus


    (1 min 3 sec) The dengue virus's outer envelope proteins form symmetrical units and overlay the lipid envelope, capsid, and the RNA genome.

  • PPAR-delta Activation in the Muscle Cell

    PPAR-delta Activation in the Muscle Cell


    (1 min 45 sec) The PPAR-delta receptor activates certain genes in a muscle cell, resulting in the burning of fat.

  • PPAR-gamma Activation in the Fat Cell

    PPAR-gamma Activation in the Fat Cell


    (2 min 49 sec) The PPAR-gamma receptor activates certain genes in a fat cell, resulting in the storage of fat and changes in hormone levels.

  • Gleevec



    (1 min 4 sec) Gleevec is a drug designed to interfere with the stimulation of growth in leukemia cells. This 3D animation shows how this is achieved.

  • Triplet code

    Triplet code


    (1 min 8 sec) Once the structure of DNA was discovered, the next challenge was determining how the sequence of letters coded for the 20 amino acids. In theory, one or two letters can only code for 4 or 16 amino acids, respectively. A scheme using three letters, a triplet code, is the minimum necessary to encode for all the amino acids.

  • DNA packaging

    DNA packaging


    (1 min 44 sec) DNA is tightly packed in the nucleus of every cell. DNA wraps around special proteins called histones, which form loops of DNA called nucleosomes. These nucleosomes coil and stack together to form fibers called chromatin. Chromatin in turn forms larger loops and coils to form chromosomes.

  • CML and Gleevec

    CML and Gleevec


    (41 sec) Chronic myeloid leukemia (CML) is caused by a mutation that leads to an abnormal protein that is always active. The drug Gleevec has a shape that fits into the active site of the abnormal protein and stops its harmful effects.

  • The Proteasome

    The Proteasome


    (1 min 44 sec) A 3D animation showing how proteins in the cell are tagged for disposal and degraded by the proteasome.

  • Myosin II Mechanism

    Myosin II Mechanism


    (57 sec) Myosin II is one of the molecules involved in furrow formation in dividing cells. This animation shows how the molecule operates, and how furrowstatin blocks the mechanism and halts division of a cell.

  • Rapamycin



    (1 min 10 sec) Rapamycin is a small molecule originally isolated from nature. It has antibiotic and immunosuppressive properties. It also allows two proteins which do not normally interact to bind together in the cell, which causes problems in the nutrient-sensing pathway.

  • Using Small Molecules to Modulate a Protein

    Using Small Molecules to Modulate a Protein


    This animation illustrates how a small molecule binds to a protein. As a result of the binding, the protein alters its shape and becomes inactivated.