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Showing 1-18 of 18 Resources
  • Fellowship of the Rings

    Fellowship of the Rings

    Image of the Week

    The nuclear pore is a complex of three rings of proteins that controls the passage of materials in and out of the nucleus.

  • Efficacy of a Treatment for Chronic Myeloid Leukemia

    Efficacy of a Treatment for Chronic Myeloid Leukemia

    Data Point

    Dr. Brian Druker and colleagues monitored white blood cell counts in six patients with chronic myeloid leukemia treated with the drug, STI571, which blocks the activity of the cancer-causing tyrosine kinase BCR-ABL.

  • To Brine, Or Not To Brine?

    To Brine, Or Not To Brine?

    Image of the Week

    Soaking your Thanksgiving turkey in a salt solution (brine) alters the arrangement of muscle fiber protein molecules.

  • BCR-ABL: Cancer Protein Structure and Function

    BCR-ABL: Cancer Protein Structure and Function

    Click & Learn

    This Click and Learn describes how understanding the structure of the BCR-ABL kinase led to the development of an effective treatment for chronic myeloid leukemia.

  • Gleevec-resistant BCR-ABL: ABL Kinase Domain

    Gleevec-resistant BCR-ABL: ABL Kinase Domain

    3D Model

    A 3D model of gleevec-resistant BCR-ABL, a mutated form of BCR-ABL.

  • BCR-ABL: ABL Kinase Domain

    BCR-ABL: ABL Kinase Domain

    3D Model

    A 3D model of BCR-ABL, an unregulated kinase that causes cancer.

  • Cancer As a Genetic Disease

    Cancer As a Genetic Disease

    Lecture

    (58 min 33 sec) Understanding that cancer is caused by mutations in genes that regulate cell proliferation has led to the development of targeted drug therapies.

  • Gleevec-Resistant Form of Kinase BCR-ABL

    Gleevec-Resistant Form of Kinase BCR-ABL

    Animation

    (2 min 14 sec) Mutations in the BCR-ABL gene can cause resistance to Gleevec, but another drug, dasatinib, can be used instead.

  • Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Animation

    (3 min 31 sec) The drug Gleevec binds to and inactivates BCR-ABL, a mutant kinase that causes chronic myeloid leukemia. 

  • Biochemistry and Cell Signaling Pathway of the Mc1r Gene

    Biochemistry and Cell Signaling Pathway of the Mc1r Gene

    Activity

    An advanced lesson that requires students to analyze partial DNA sequences of the Mc1r gene and identify the effects of mutations on the MC1R protein pathway.

  • Biodiversity at a Snail's Pace

    Biodiversity at a Snail's Pace

    Lecture

    (58 min 29 sec) Cone snails have evolved many different toxins for different uses. Total molecular biodiversity may number in the millions.

  • PPAR-gamma Activation in the Fat Cell

    PPAR-gamma Activation in the Fat Cell

    Animation

    (2 min 49 sec) The PPAR-gamma receptor activates certain genes in a fat cell, resulting in the storage of fat and changes in hormone levels.

  • The Proteasome and Protein Regulation

    The Proteasome and Protein Regulation

    Click & Learn

    Learn about the structure and function of this fascinating cellular machine.

  • A Healthy Nervous System: A Delicate Balance

    A Healthy Nervous System: A Delicate Balance

    Lecture

    (58 min 32 sec) Mutations in key genes can lay waste to the nervous system. By studying large families predisposed to developing these genetic disorders, scientists can identify the responsible altered gene.

  • Gleevec

    Gleevec

    Animation

    (1 min 4 sec) Gleevec is a drug designed to interfere with the stimulation of growth in leukemia cells. This 3D animation shows how this is achieved.

  • CML and Gleevec

    CML and Gleevec

    Animation

    (41 sec) Chronic myeloid leukemia (CML) is caused by a mutation that leads to an abnormal protein that is always active. The drug Gleevec has a shape that fits into the active site of the abnormal protein and stops its harmful effects.

  • The Proteasome

    The Proteasome

    Animation

    (1 min 44 sec) A 3D animation showing how proteins in the cell are tagged for disposal and degraded by the proteasome.

  • Myosin II Mechanism

    Myosin II Mechanism

    Animation

    (57 sec) Myosin II is one of the molecules involved in furrow formation in dividing cells. This animation shows how the molecule operates, and how furrowstatin blocks the mechanism and halts division of a cell.

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