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  • Trojan Micro Horses

    Trojan Micro Horses

    Image of the Week

    Spheres made from sugar polymers hide insulin-producing cells from attack by the immune system.

  • Coloring the Past

    Coloring the Past

    Image of the Week

    An electron micrograph of tightly-packed melanosomes in a 55.4-million-year-old fossil bird feather unearthed in Denmark.

  • How We Get Our Skin Color Interactive

    How We Get Our Skin Color Interactive

    Interactive Video

    (3 min 32 sec) This interactive animation about the biology of skin color provides stop points at which students can further explore the material through additional text and illustrations, videos, questions, and simple interactive widgets.

  • What Makes Flowers Red?

    What Makes Flowers Red?

    Image of the Week

    The petals of flowers get their vibrant colors from cells packed with pigments such as orange carotenoids and pink anthocyanins.

  • BCR-ABL: Cancer Protein Structure and Function

    BCR-ABL: Cancer Protein Structure and Function

    Click & Learn

    This Click and Learn describes how understanding the structure of the BCR-ABL kinase led to the development of an effective treatment for chronic myeloid leukemia.

  • Dasatinib

    Dasatinib

    3D Model

    A 3D model of dasatinib, a drug that can inhibit BCR-ABL and Gleevec-resistant BCR-ABL.


  • Imatinib (Gleevec)

    Imatinib (Gleevec)

    3D Model

    A 3D model of imatinib (Gleevec), a drug that mimics ATP and inhibits BCR-ABL.

  • Adenosine Triphosphate (ATP)

    Adenosine Triphosphate (ATP)

    3D Model

    A 3D model of adenosine triphosphate, or ATP.

  • Gleevec-Resistant Form of Kinase BCR-ABL

    Gleevec-Resistant Form of Kinase BCR-ABL

    Animation

    (2 min 14 sec) Mutations in the BCR-ABL gene can cause resistance to Gleevec, but another drug, dasatinib, can be used instead.

  • Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Animation

    (3 min 31 sec) The drug Gleevec binds to and inactivates BCR-ABL, a mutant kinase that causes chronic myeloid leukemia. 

  • Biochemistry and Cell Signaling Pathway of the Mc1r Gene

    Biochemistry and Cell Signaling Pathway of the Mc1r Gene

    Activity

    An advanced lesson that requires students to analyze partial DNA sequences of the Mc1r gene and identify the effects of mutations on the MC1R protein pathway.

  • Eavesdropping on Tiny Conspiracies

    Eavesdropping on Tiny Conspiracies

    Lecture

    (58 min 29 sec) The quorum sensing system is a target for a new class of drugs that interfere with virulence without killing bacteria.

  • Demonstration: Quorum sensing molecules

    Demonstration: Quorum sensing molecules

    Clip

    (50 sec) Quorum sensing signal molecules have parts that are common between species as well as species-specific parts.

  • The LUX operon controls light production

    The LUX operon controls light production

    Animation

    (2 min 25 sec) A single transcription factor controls this operon, which contains five genes necessary to produce bioluminescence.

  • Signal molecules trigger transcription factors

    Signal molecules trigger transcription factors

    Animation

    (2 min 4 sec) Varying concentrations of a signaling molecule activate different transcription factors and determine cell fate.

  • Gleevec

    Gleevec

    Animation

    (1 min 4 sec) Gleevec is a drug designed to interfere with the stimulation of growth in leukemia cells. This 3D animation shows how this is achieved.

  • CML and Gleevec

    CML and Gleevec

    Animation

    (41 sec) Chronic myeloid leukemia (CML) is caused by a mutation that leads to an abnormal protein that is always active. The drug Gleevec has a shape that fits into the active site of the abnormal protein and stops its harmful effects.

  • Myosin II Mechanism

    Myosin II Mechanism

    Animation

    (57 sec) Myosin II is one of the molecules involved in furrow formation in dividing cells. This animation shows how the molecule operates, and how furrowstatin blocks the mechanism and halts division of a cell.

  • Diffusion Across Membranes

    Diffusion Across Membranes

    Animation

    (4 sec) This animation describes two different ways by which chemicals migrate through membranes: passive diffusion and active transport.

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